Patents by Inventor Paul Sweetnam
Paul Sweetnam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7374906Abstract: The present invention discloses a device for monitoring chemotaxis or chemoinvasion. The present invention further provides a flexible assay system and numerous assays that can be used to test biological interactions and systems. Laminar flow gradients are employed that mimic gradient situations present in vivo.Type: GrantFiled: October 21, 2003Date of Patent: May 20, 2008Assignee: Surface Logix, Inc.Inventors: Gregory L. Kirk, Emanuele Ostuni, Enoch Kim, Olivier Schueller, Paul Sweetnam
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Patent number: 7364899Abstract: The present invention discloses a device for monitoring haptotaxis including a housing defining a chamber. The chamber comprises: a first well region including at least one first well, the first well configured to receive a test agent therein and further including biomolecules immobilized therein; a second well region including at least one second well, the second well region configured to receive a sample comprising cells therein and further being horizontally offset with respect to the first well region in a test orientation of the device; and a channel region including at a least one channel connecting the first well region and the second well region with one another, the channel region further including biomolecules immobilized therein.Type: GrantFiled: March 15, 2002Date of Patent: April 29, 2008Assignee: Surface Logix Inc.Inventors: Gregory L. Kirk, Matthew Brown, Emanuele Ostuni, Enoch Kim, Bernardo D. Aumond, Olivier Schueller, Paul Sweetnam, Brian Benoit
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Publication number: 20070166816Abstract: This invention provides device for co-culturing at least two different cell types in a two-dimensional configuration, methods of patterning at least two different cell types in a two-dimensional co-culture configuration, and uses of these devices and methods for analyzing an effect of candidate compound on such cellular cocultures. Also provided is a transmigration and extravasation device. Assay devices for analyzing the absorption, permeability, metabolism and/or toxicity of a candidate compound by a cell are provided. A microfluidic network, which is adaptable for integration with a device for coculturing is provided.Type: ApplicationFiled: December 13, 2006Publication date: July 19, 2007Applicant: Surface Logix, Inc.Inventors: Stewart Campbell, Enoch Kim, Gregory Kirk, Emanuele Ostuni, Olivier Schueller, Rocco Casagrande, Evelyn Wang, Paul Sweetnam
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Publication number: 20070038384Abstract: The present invention further relates to utilizing the above devices and methods for assaying cellular dynamics and phenotypes to create subject primary cell profiles for patients. Additionally, the present invention relates to methods of correlating primary cell profiles with a therapeutic regimen. Finally, the invention relates to methods for screening test compounds for biological activities by measuring their effect on primary cell profiles.Type: ApplicationFiled: January 5, 2006Publication date: February 15, 2007Inventors: Gregory Kirk, Emanuele Ostuni, Enoch Kim, Olivier Schueller, Paul Sweetnam
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Publication number: 20070027183Abstract: The present invention relates to compounds which are inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (Apo B) secretion. These compounds can be useful for the prevention and treatment of various diseases, particularly atherosclerosis and its clinical sequelae, for lowering serum lipids, and related ailments. The invention further relates to pharmaceutical compositions comprising the compounds and to methods of treating diseases, such as hypertriglyceridemia, hyperchylomicronemia, atherosclerosis, obesity, and related conditions using the compounds. A method for decreasing apolipoprotein B (apo B) secretion is also provided.Type: ApplicationFiled: April 19, 2006Publication date: February 1, 2007Applicant: Surface Logix, Inc.Inventors: Alessandra Bartolozzi, Stewart Campbell, Hope Foudoulakis, Enoch Kim, Paul Sweetnam, Yingfei Yang
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Patent number: 7166459Abstract: The present invention discloses a test device including a support member; a top member mounted to the support member, wherein in the support member and the top member are configured such that they together define a discrete chamber. The discrete chamber includes a first well region including at least one first well; a second well region including at least one second well; and a channel region including at least one channel connecting the first well region and the second well region with one another. The second region is preferably horizontally offset with respect to the first well region in a test orientation of the device.Type: GrantFiled: March 15, 2002Date of Patent: January 23, 2007Assignee: Surface Logix, Inc.Inventors: Gregory Kirk, Matthew Brown, Emanuele Ostuni, Enoch Kim, Bernardo Aumond, Olivier Schueller, Paul Sweetnam, Brian Benoit
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Patent number: 7123764Abstract: An image processing method for use in analyzing image data of a cellular migration assay. The method includes defining a major axis within the image data that is perpendicular to an orientation of channels in the image data, determining an aggregate light intensity within the image data along the major axis, and identifying locations of channels within the image data from the projection.Type: GrantFiled: March 15, 2002Date of Patent: October 17, 2006Assignee: Surface Logix Inc.Inventors: Gregory L. Kirk, Matthew Brown, Emanuele Ostuni, Enoch Kim, Bernardo D. Aumond, Olivier Schueller, Paul Sweetnam, Brian Benoit
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Patent number: 6921660Abstract: The present invention discloses a device for monitoring chemotaxis or chemoinvasion including a housing comprising: a support member and a top member, the top member mounted to the support member by being placed in substantially fluid-tight conformal contact with the support member. The support member and the top member are configured such that they together define a discrete chamber adapted to allow a monitoring of chemotaxis or chemoinvasion therein. The discrete chamber includes a first well region including at least one first well, the at least one first well configured to received a test agent therein; a second well region including at least one second well, the at least one second well configured to receive a sample comprising cells therein; and a channel region including at least one channel connecting the first well region and the second well region with one another. The second well region is preferably horizontally offset with respect to the first well region in a test orientation of the device.Type: GrantFiled: March 15, 2002Date of Patent: July 26, 2005Assignee: Surface Logix, Inc.Inventors: Gregory L. Kirk, Matthew Brown, Emanuele Ostuni, Enoch Kim, Bernardo D. Aumond, Olivier Schueller, Paul Sweetnam, Brian Benoit
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Patent number: 6818403Abstract: The present invention discloses a method of monitoring haptotaxis comprising: providing a device for monitoring haptotaxis having a housing defining a chamber. The chamber includes: a first well region including at least one first well, the first well region configured to receive a test agent therein and further including biomolecules immobilized therein; a second well region including at least one second well, the second well region configured to receive a sample comprising cells therein and further being horizontally offset with respect to the first well region in a test orientation of the device; and a channel region with biomolecules immobilized therein and including at least one channel connecting the first well region and the second well region with one another.Type: GrantFiled: March 15, 2002Date of Patent: November 16, 2004Assignee: Surface Logix, Inc.Inventors: Gregory L. Kirk, Matthew Brown, Emanuele Ostuni, Enoch Kim, Bernardo D. Aumond, Olivier Schueller, Paul Sweetnam, Brian Benoit
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Patent number: 6811968Abstract: The present invention discloses a method of monitoring chemotaxis or chemoinvasion comprising: providing a device for monitoring chemotaxis. The device includes a support member; a top member mounted to the support member by being placed in substantially fluid-tight, conformal contact with the support member. The support member and the top member are configured such that they together define a discrete assay chamber. The discrete assay chamber includes a first well region including at least one first well, the at least one first well being configured to receive a soluble test substance therein; a second well region including at least one second well, the at least one second well being configured to receive a sample comprising cells therein; and a channel region including at least one channel connecting the first well region and the second well region. Preferably, at least one second well is horizontally offset with respect to the first well region in a test orientation of the device.Type: GrantFiled: March 15, 2002Date of Patent: November 2, 2004Assignee: Surface Logix Inc.Inventors: Gregory L. Kirk, Matthew Brown, Emanuele Ostuni, Enoch Kim, Bernardo D. Aumond, Olivier Schueller, Paul Sweetnam, Brian Benoit
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Publication number: 20040142408Abstract: A device for monitoring leukocyte migration is provided. The invention also provides a method of using the device to monitor leukocyte migration in the presence of physiological shear flow and therefore simulate physiological conditions of a blood vessel in vivo. The invention further provides a method of using the device to high-throughput screen a plurality of test agents. The present invention further provides a flexible assay system and numerous assays that can be used to test biological interactions and systems. Laminar flow gradients are employed that mimic gradient situations present in vivo.Type: ApplicationFiled: October 21, 2003Publication date: July 22, 2004Inventors: Gregory L. Kirk, Emanuele Ostuni, Enoch Kim, Olivier Schueller, Paul Sweetnam
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Publication number: 20040142411Abstract: The present invention discloses a device for monitoring chemotaxis or chemoinvasion. The present invention further provides a flexible assay system and numerous assays that can be used to test biological interactions and systems. Laminar flow gradients are employed that mimic gradient situations present in vivo.Type: ApplicationFiled: October 21, 2003Publication date: July 22, 2004Inventors: Gregory L. Kirk, Emanuele Ostuni, Enoch Kim, Olivier Schueller, Paul Sweetnam
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Publication number: 20030215941Abstract: This invention provides device for co-culturing at least two different cell types in a two-dimensional configuration, methods of patterning at least two different cell types in a two-dimensional co-culture configuration, and uses of these devices and methods for analyzing an effect of candidate compound on such cellular cocultures. Also provided is a transmigration and extravasation device. Assay devices for analyzing the absorption, permeability, metabolism and/or toxicity of a candidate compound by a cell are provided. A microfluidic network, which is adaptable for integration with a device for coculturing is provided.Type: ApplicationFiled: March 12, 2003Publication date: November 20, 2003Inventors: Stewart Campbell, Enoch Kim, Gregory L. Kirk, Emanuele Ostuni, Olivier Schueller, Rocco Casagrande, Evelyn Wang, Paul Sweetnam
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Publication number: 20030022197Abstract: The present invention discloses a device for monitoring haptotaxis including a housing defining a chamber. The chamber comprises: a first well region including at least one first well, the first well configured to receive a test agent therein and further including biomolecules immobilized therein; a second well region including at least one second well, the second well region configured to receive a sample comprising cells therein and further being horizontally offset with respect to the first well region in a test orientation of the device; and a channel region including at a least one channel connecting the first well region and the second well region with one another, the channel region further including biomolecules immobilized therein.Type: ApplicationFiled: March 15, 2002Publication date: January 30, 2003Inventors: Greg Kirk, Matthew Brown, Emanuelle Ostuni, Enoch Kim, Bernado D. Aumond, Olivier Schueller, Paul Sweetnam, Brian Benoit
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Publication number: 20030022269Abstract: The present invention discloses a method of monitoring chemotaxis or chemoinvasion comprising: providing a device for monitoring chemotaxis. The device includes a support member; a top member mounted to the support member by being placed in substantially fluid-tight, conformal contact with the support member. The support member and the top member are configured such that they together define a discrete assay chamber. The discrete assay chamber includes a first well region including at least one first well, the at least one first well being configured to receive a soluble test substance therein; a second well region including at least one second well, the at least one second well being configured to receive a sample comprising cells therein; and a channel region including at least one channel connecting the first well region and the second well region. Preferably, at least one second well is horizontally offset with respect to the first well region in a test orientation of the device.Type: ApplicationFiled: March 15, 2002Publication date: January 30, 2003Inventors: Gregory Kirk, Matthew Brown, Emanuele Ostuni, Enoch Kim, Bernardo D. Aumond, Olivier Schueller, Paul Sweetnam, Brian Benoit
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Publication number: 20030022362Abstract: The present invention discloses a device for monitoring chemotaxis or chemoinvasion including a housing comprising: a support member and a top member, the top member mounted to the support member by being placed in substantially fluid-tight conformal contact with the support member. The support member and the top member are configured such that they together define a discrete chamber adapted to allow a monitoring of chemotaxis or chemoinvasion therein. The discrete chamber includes a first well region including at least one first well, the at least one first well configured to received a test agent therein; a second well region including at least one second well, the at least one second well configured to receive a sample comprising cells therein; and a channel region including at least one channel connecting the first well region and the second well region with one another. The second well region is preferably horizontally offset with respect to the first well region in a test orientation of the device.Type: ApplicationFiled: March 15, 2002Publication date: January 30, 2003Inventors: Gregory Kirk, Matthew Brown, Emanuele Ostuni, Enoch Kim, Bernard D. Aumond, Olivier Schueller, Paul Sweetnam, Brian Benoit
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Publication number: 20030022153Abstract: The present invention discloses a method of monitoring haptotaxis comprising: providing a device for monitoring haptotaxis having a housing defining a chamber. The chamber includes: a first well region including at least one first well, the first well region configured to receive a test agent therein and further including biomolecules immobilized therein; a second well region including at least one second well, the second well region configured to receive a sample comprising cells therein and further being horizontally offset with respect to the first well region in a test orientation of the device; and a channel region with biomolecules immobilized therein and including at least one channel connecting the first well region and the second well region with one another.Type: ApplicationFiled: March 15, 2002Publication date: January 30, 2003Inventors: Gregory Kirk, Matthew Brown, Emanuele Ostuni, Enoch Kim, Bernardo D. Aumond, Olivier Schueller, Paul Sweetnam, Brian Benoit
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Publication number: 20030021457Abstract: An image processing method for use in analyzing image data of a cellular migration assay. The method includes defining a major axis within the image data that is perpendicular to an orientation of channels in the image data, determining an aggregate light intensity within the image data along the major axis, and identifying locations of channels within the image data from the projection.Type: ApplicationFiled: March 15, 2002Publication date: January 30, 2003Inventors: Gregory Kirk, Matthew Brown, Emanuele Ostuni, Enoch Kim, Bernardo D. Aumond, Olivier Schueller, Paul Sweetnam, Brian Benoit
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Publication number: 20020168757Abstract: The present invention discloses a test device including a support member; a top member mounted to the support member, wherein in the support member and the top member are configured such that they together define a discrete chamber. The discrete chamber includes a first well region including at least one first well; a second well region including at least one second well; and a channel region including at least one channel connecting the first well region and the second well region with one another. The second region is preferably horizontally offset with respect to the first well region in a test orientation of the device.Type: ApplicationFiled: March 15, 2002Publication date: November 14, 2002Inventors: Gregory Kirk, Matthew Brown, Emanuele Ostuni, Enoch Kim, Bernardo D. Aumond, Olivier Schueller, Paul Sweetnam, Brian Benoit