Abstract: The present disclosure provides aromatic-cationic peptides and methods of using the same. The methods comprise the use of the aromatic-cationic peptides in reducing the effects of toxic beta amyloid (A?) peptides including blocking the accumulation of extracellular A? oligomers, inhibiting A?-mediated oxygenase activity, reducing A?-induced mitochondrial dysfunction and/or preventing A?-induced neuronal apoptosis.

Abstract: A method and system is directed to routing a flow of packets over a network to multiple traffic management devices. An apparatus receives each packet from a network and forwards the packet to one of a group of traffic management devices. The apparatus also may receive packets from servers for which the traffic management devices are managing communications. When forwarding packets, a traffic management device is selected from the group of traffic management devices by employing a hash of an IP address and port number. The IP address and port number are selected from source or destination information in the packet that has a greater port number. When the traffic management device performs a network address translation, further actions may be performed so that packets that are part of a flow between two network devices are delivered to the same traffic management device.

Abstract: A method and system for protection against denial of service attacks to a server coupled to a network. The server may establish connections with client computers through the network. Packets are received over the network directed to the server. It is determined whether the packets are associated with an established connection. The packets associated with the established connection are separated for processing by the server in a first buffer. The packets requesting a new connection are separated in a second buffer. The packets in the second buffer requesting a new connection are serviced at a lower priority than the packets relating to established connections.

Abstract: The present invention provides improved immunoaffinity methods for detecting high avidity anti-amyloid antibodies present in a biological sample. In other aspects, the present invention provides methods for diagnosing diseases associated with amyloid proteins. Also provided by the present invention are methods for identifying candidates likely to respond to treatment comprising administration of an immunoglobulin preparation.

Abstract: A method and system is directed to routing a flow of packets over a network to multiple traffic management devices. An apparatus receives each packet from a network and forwards the packet to one of a group of traffic management devices. The apparatus also may receive packets from servers for which the traffic management devices are managing communications. When forwarding packets, a traffic management device is selected from the group of traffic management devices by employing a hash of an IP address and port number. The IP address and port number are selected from source or destination information in the packet that has a greater port number. When the traffic management device performs a network address translation, further actions may be performed so that packets that are part of a flow between two network devices are delivered to the same traffic management device.

Abstract: A system for distributing network traffic to multiple traffic management devices. A distributor receives each packet from a network and may act as a layer 2 switch, a router, or distribute the packet to one of a group of traffic management devices. The distributor may receive packets from servers that the traffic management devices are managing communications to. When distributing packets to traffic management devices, information such as source and destination addresses may be used to determine which traffic management device each packet should be sent to. The distributor causes packets that are part of a flow to be delivered to the same traffic management device.

Abstract: A method and system is directed to routing a flow of packets over a network to multiple traffic management devices. An apparatus receives each packet from a network and forwards the packet to one of a group of traffic management devices. The apparatus also may receive packets from servers for which the traffic management devices are managing communications. When forwarding packets, a traffic management device is selected from the group of traffic management devices by employing a hash of an IP address and port number. The IP address and port number are selected from source or destination information in the packet that has a greater port number. When the traffic management device performs a network address translation, further actions may be performed so that packets that are part of a flow between two network devices are delivered to the same traffic management device.

Abstract: A system for distributing network traffic to multiple traffic management devices. A distributor receives each packet from a network and may act as a layer 2 switch, a router, or distribute the packet to one of a group of traffic management devices. The distributor may receive packets from servers that the traffic management devices are managing communications to. When distributing packets to traffic management devices, information such as source and destination addresses may be used to determine which traffic management device each packet should be sent to. The distributor causes packets that are part of a flow to be delivered to the same traffic management device.

Abstract: Processes for generating aqueous dispersions for use in the emulsion/aggregation technique, by combining crystalline polyester resin, amorphous polyester resin and water, heating and agitating the mixture and generating an aqueous dispersion containing both crystalline polyester resin particles and amorphous polyester resin particles.

Abstract: The invention provides anti-amyloid-? immunoglobulin preparations that have been treated to remove amyloid-? ligands.

Abstract: The invention provides a method for assessing risk of a neurodegenerative disease or disorder in a subject. The method comprises comparing a level of anti-&bgr;-amyloid-42 (A&bgr;42) antibody in a biological sample from a subject to a normal level, wherein a lower level in the biological sample from the subject indicates the risk of the disease or disorder. In a specific embodiment, the disease or disorder is Alzheimer's Disease (AD).

Abstract: The invention provides a method for assessing risk of a neurodegenerative disease or disorder in a subject. The method comprises comparing a level of anti-amyloid peptide antibody in a biological sample from a subject to a normal level, wherein a lower level in the biological sample from the subject indicates the presence of the disease or disorder. In a specific embodiment, the disease or disorder is Alzheimer's Disease (AD); in a further specific embodiment, the amyloid peptide is &bgr;-amyloid-42 (A&bgr;42).

Abstract: A hand-held transmitter (T) delivers an IR control signal to a receiver (R) that is connected to send the signal to a lighting control module (LCM) within a housing (16). A cable (18) of light strings (20, 22, 24, 26) and a common conductor (28) extends away from the housing (16) a distance sufficient to provide a desired number of lights (30, 32, 34, 36). All lights (30, 32, 34, 36) may be the same color or each light string (20, 22, 24, 26) may have lights of a color different from the color of any other light string. The receiver conductor 39 may be wound on the cable (18). In use, an AC plug (12) is plugged into an AC receptacle. A first length of wiring (14) and the receiver conductor (39) space the receiver (R) a predetermined distance from the AC receptacle. This allows the receiver (R) to be positioned forwardly of a Christmas tree or other object in which the light display (10) is placed.

Abstract: In accordance with the method and system of the present invention, a local processor utilizes registers arranged in a fault/mask/cache fashion for environmental control and sensing within a data processing system. The local processor continuously reads input data from a variety of environmental sensors in order to determine if a threshold level has been reached and a fault condition exists. Cache registers allow the local processor to store/pass detailed sensor information to system firmware within system processor(s). The local processor sets a fault bit within a fault register designed to cause an interrupt to the system level firmware if any of its bits are non-zero, indicating that a fault condition has occurred. A mask register is designed to allow the interaction of both the local processor and system processor(s) when an interrupt is being serviced and help keeps track of which interrupts are being serviced and which are yet to be serviced in the case of multiple interrupt sources.

Abstract: A method and implementing apparatus is provided which include a plurality of perceptible indicia devices which are mounted on an I/O drawer of a computer system server equipment rack. In the exemplary embodiment, the indicia devices include a light-emitting diode in combination with an alphanumeric display device. Various states of a system initialization process are indicated by different combinations of possible states of the LED and the display device such that the sequencing of a system initialization process can be traced by visual inspection of the status of the perceptible indicia devices.

Abstract: A data processing system includes a plurality of components, a power control network, processing resources, and a memory that contains initialization firmware. At system startup, the power control network initiates supply of power to the plurality of components and collects information regarding which components are supplied power. In addition, the initialization firmware initializes the plurality of components to establish a configuration. If an ambiguity in the configuration arises, the initialization firmware resolves the ambiguity utilizing the information collected by the power control network.

Abstract: A multitude of devices coupled to a processor are each given a location code, which is then displayed in proximity to each of the devices. Then, when the processor indicates an error within a particular device, the service person can easily find which device has the error by the displayed location code associated with the device.

Abstract: The present invention is directed to methods which employ inhibition of the post-translational hypusine formation in the intracelluar protein eIF-5A, for the purpose of suppressing infections by viruses that parasitize eIF-5A so as to promote their own replication. Intentional inhibition of the post-translational formation of hypusine in infected host cells with compounds generically termed `hypusine inhibitors` not only selectively suppresses the production of viral proteins and of infectious viral particles, but also causes, particularly after hypusine inhibitor withdrawal, apoptosis in such virally-infected cells.

Abstract: A method and apparatus for producing self-diagnostic information from a circuit board. A circuit board is provided with an on-board processor, an on-board ROM containing diagnostic test software, a frequency generator adapted to produce an electrical signal having a predetermined frequency when an unacceptable response is determined, wherein the predetermined frequency corresponds substantially to the event within the diagnostic test sequence of a particular test for which an unacceptable response is determined. The signal is presented at an output terminal of the circuit board. The status of the circuit board is determined by measuring the frequency of the signal at the output terminal and comparing that frequency to an index of corresponding defects.

Abstract: The present invention relates to an isolated protein or polypeptide capable of production by T cells and capable of ultimately activating production of B cells. The present invention further provides an isolated DNA molecule encoding the protein or polypeptide capable of production by T cells and capable of ultimately activating production of B cells. The isolated DNA molecule can be inserted as a heterologous DNA in an expression vector forming a recombinant DNA expression system for producing the protein or polypeptide. Likewise, the heterologous DNA can be incorporated in a cell to achieve this objective. The isolated protein or polypeptide of the present invention can be combined with a pharmaceutically-acceptable carrier or used alone for administration to mammals for activating production of B cells.