Abstract: Compounds are provided having the following structure: (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R2a, R2b, R3a, R3b, R7, R8, R9, L1, L2, G1, G2, G3, b, and c are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

Abstract: Co-manipulation robotic systems are described herein that may be used for assisting with laparoscopic surgical procedures. The co-manipulation robotic systems allow a surgeon to use commercially-available surgical tools while providing benefits associated with surgical robotics. Advantageously, the surgical tools may be seamlessly coupled to the robot arms using a disposable coupler while the reusable portions of the robot arm remain in a sterile drape. Further, the co-manipulation robotic system may operate in multiple modes to enhance usability and safety, while allowing the surgeon to position the instrument directly with the instrument handle and further maintain the desired position of the instrument using the robot arm.

Abstract: Compounds are provided having the following structure: (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

Abstract: Provided are anti-ABCB 1 antibodies that may be used as multi-specific, including bispecific, antibodies targeting both ABCB 1 and a tumor-associated antigen (TAA), as well as pharmaceutical compositions, nucleic acids, recombinant expression vectors, cells, and kits that include or encode such antibodies and multi-specific antibodies. Further included are uses and methods of treating conditions where inhibition of ABCB 1-mediated efflux transport is desirable, such as, cancer or multi-drug resistance mediated by the ABCB1 transporter, e.g., multi-drug resistant cancer. In particular, the disclosure provides humanized multi-specific, e.g. bispecific, IgG (IgG1) antibodies that bind ABCB1 and a TAA. Multi-specific IgG1 antibody molecules are provided with Fc substitutions in at least one of a first and a second heavy chain constant region.

Abstract: 2D nearest-neighbor quantum architectures for Shor's factoring algorithm may be accomplished using the form of three arithmetic building blocks: modular addition using Gossett's carry-save addition, modular multiplication using Montgomery's method, and non-modular multiplication using an original method. These arithmetic building blocks may assume that ancillae are cheap, that concurrent control may be available and scalable, and that execution time may be the bottleneck. Thus, the arithmetic building blocks may be optimized in favor of circuit width to provide improved depth existing nearest-neighbor implementations.

Abstract: A cleaning method including an alkaline cleaning step followed by an acid cleaning step is used, for example, to treat a newly constructed ultrapure water distribution piping system (using PVDF piping system). The inherent inorganic and organic contaminants in the piping material as well as contaminants deposited (if any) during the construction phase can be removed efficiently. Therefore, the commissioning time of a newly constructed ultrapure water distribution system to meet the specified quality of contaminants can be shortened from several weeks to approximately one week.

Abstract: 2D nearest-neighbor quantum architectures for Shor's factoring algorithm may be accomplished using the form of three arithmetic building blocks: modular addition using Gossett's carry-save addition, modular multiplication using Montgomery's method, and non-modular multiplication using an original method. These arithmetic building blocks may assume that ancillae are cheap, that concurrent control may be available and scalable, and that execution time may be the bottleneck. Thus, the arithmetic building blocks may be optimized in favor of circuit width to provide improved depth existing nearest-neighbor implementations.

Abstract: A slurry supply system with multiple supply modules and a flushing module concurrently coupled to the multiple supply modules is provided. Each supply module includes a slurry reservoir and at least one delivery line connecting to the slurry reservoir, wherein each delivery line is oriented toward a chemical mechanical polishing apparatus. The flushing module includes a flushing liquid reservoir and multiple flushing lines connecting to the flushing liquid reservoir, wherein each flushing line is coupled to each delivery line thereby the flush module can selectively flush one of the delivery lines.

Abstract: Techniques for image browsing, navigating and user interface operation are described herein. An image cube, having three axes representing a medical patient's body parts, imaging technology and image date, may be displayed on a visual display. Image piles of icons or thumbnail images may be positioned within the image cube, according to the three axes. By fixing the body parts axis on a specific body part, an image plane may be selected from the image cube. The selected image plane replaces the image cube in the visual display, including only image piles of the selected body part, organized according to axes indicating imaging technology and image date. An image pile may be selected from the image plane, to replace the image plane on the visual display. Image pile operations allow the user to select from the image pile a desired image(s) for display.

Abstract: A slurry supply system with multiple supply modules and a flushing module concurrently coupled to the multiple supply modules is provided. Each supply module includes a slurry reservoir and at least one delivery line connecting to the slurry reservoir, wherein each delivery line is oriented toward a chemical mechanical polishing apparatus. The flushing module includes a flushing liquid reservoir and multiple flushing lines connecting to the flushing liquid reservoir, wherein each flushing line is coupled to each delivery line thereby the flush module can selectively flush one of the delivery lines.

Abstract: A slurry dispensing system comprises a first supply station, a second supply station, a first loop, a second loop, a first valve and a second valve. The first loop is selectively connected to the first supply station and the second supply station. The second loop is also selectively connected to the first supply station and the second supply station. The first valve connects the first loop to points of use. The second valve connects the second loop to the points of use. When slurry is supplied to the first loop from the first slurry station, slurry is supplied to the second loop from the second slurry station. When the first valve is opened and the second valve is closed, slurry is supplied to the points of use from the first loop.

Abstract: A slurry dispensing system comprises a first supply station, a second supply station, a first loop, a second loop, a first valve and a second valve. The first loop is selectively connected to the first supply station and the second supply station. The second loop is also selectively connected to the first supply station and the second supply station. The first valve connects the first loop to points of use. The second valve connects the second loop to the points of use. When slurry is supplied to the first loop from the first slurry station, slurry is supplied to the second loop from the second slurry station. When the first valve is opened and the second valve is closed, slurry is supplied to the points of use from the first loop.

Abstract: A low cost and long lasting hinge mechanism suitable for hinging a cover to a housing of a device is disclosed. The hinge mechanism has a pair of pins attached to the cover and a corresponding pair of apertures on the housing. The pins fit into the apertures to hinge the cover to the housing to allow the cover to be tilted from a closed position to an open position. The aperture has a first portion and a second constricted portion. A pivoting point is provided on a tab on the housing. A corresponding cam-profiled section is provided on the cover for interacting with the pivoting point to urge the pin into the corresponding constricted portion of the aperture for securing the cover in the open position.

Abstract: The present invention provides polypeptides comprising an immunogenic portion of a M. vaccae soluble protein and DNA molecules encoding such polypeptides, together with methods for their use in the diagnosis and treatment of mycobacterial infection. Methods for enhancing the immune response to an antigen including administration of M. vaccae culture filtrate or delipidated M. vaccae cells are also provided.

Abstract: The present invention provides polypeptides comprising an immunogenic portion of a M. vaccae protein and DNA molecules encoding such polypeptides, together with methods for their use in the diagnosis and treatment of mycobacterial infection. Methods for enhancing the immune response to an antigen including administration of M. vaccae culture filtrate, delipidated M. vaccae cells or delipidated and deglycolipidated M. vaccae cells are also provided.

Abstract: A computer device comprises a casing in which are accommodated an electronic circuit and a touch screen, a protective cover movably arranged on the casing for selectively covering and uncovering at least the touch screen, and a stylus for operating said touch screen. The protective cover includes a compartment which substantially corresponds to the shape of at least part of the stylus and in which the stylus is removably stored, thereby reducing the size of the computer device for more convenient handling of the same by a user.

Abstract: The present invention provides polypeptides comprising an immunogenic portion of a M. vaccae soluble protein and DNA molecules encoding such polypeptides, together with methods for their use in the diagnosis and treatment of mycobacterial infection. Methods for enhancing the immune response to an antigen including administration of M. vaccae culture filtrate or delipidated M. vaccae cells are also provided.

Abstract: An arrangement of a first receptacle and a second receptacle for separately receiving a card device in a portable computer. The first and second card receptacles are coupled to allow movement of the receptacles relative to each other between a first configuration where the receptacles are substantially nested, and a second configuration where the receptacles are substantially stacked, such that the receptacles move from the first configuration to the second configuration in order to receive a card device in the first receptacle.