Abstract: Co-manipulation robotic systems are described herein that may be used for assisting with laparoscopic surgical procedures. The co-manipulation robotic systems allow a surgeon to use commercially-available surgical tools while providing benefits associated with surgical robotics. Advantageously, the surgical tools may be seamlessly coupled to the robot arms using a disposable coupler while the reusable portions of the robot arm remain in a sterile drape. Further, the co-manipulation robotic system may operate in multiple modes to enhance usability and safety, while allowing the surgeon to position the instrument directly with the instrument handle and further maintain the desired position of the instrument using the robot arm.

Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: One example method for biomarker detection in digitized pathology samples includes receiving a plurality of image patches corresponding to an image of a pathology slide having a hematoxylin and eosin-stained (“H&E”) stained sample of tissue, each image patch representing a different portion of the image; for each image patch, determining, using a first trained machine learning (“ML”) model, a patch biomarker status; and determining, using a second trained ML model, a tissue sample biomarker status for the sample of tissue based on the patch biomarker statuses of the image patches.

Abstract: A technique to execute transpose and compute operations may include retrieving a set of machine instructions from an instruction buffer of a data processor. The instruction buffer has multiple entries, and each entry stores one machine instruction. A machine instruction from the set of machine instructions is executed to transpose a submatrix of an input tensor and perform computations on column elements of the submatrix. The machine instruction combines the transpose operation with computational operations into a single machine instruction.

Abstract: An integrated circuit that combines transpose and compute operations may include a transpose circuit coupled to a set of compute channels. Each compute channel may include multiple arithmetic logic unit (ALU) circuits coupled in series. The transpose circuit is operable to receive an input tensor, transpose the input tensor, and output a transposed tensor to the set of compute channels. The set of compute channels is operable to generate outputs in parallel, with each of the outputs being generated from a corresponding vector of the transposed tensor.

Abstract: Techniques to take advantage of the single-instruction-multiple-data (SIMD) capabilities of a processor to process data blocks can include implementing an instruction to fuse the data blocks together. The fuse input instruction can have a first input vector, a second input vector, a select input, a first output vector, and a second output vector. The fuse input instruction selects a portion of the first input vector and a portion of the second input vector based on the select input, sign extends the selected portion of the first input vector and the selected portion of the second input vector, and shuffles data elements of the sign extended portion of the first input vector with data elements of the sign extended portion of the second input vector to generate the first and second output vectors.

Abstract: A patient interface for delivery of a supply of pressurised air or breathable gas to an entrance of a patient's airways comprising: a cushion member that includes a retaining structure and a seal-forming structure permanently connected to the retaining structure; a frame member attachable to the retaining structure; and a positioning and stabilising structure attachable to the frame member.

Abstract: Disclosed is a food processing apparatus having a food processing chamber, comprising a blade arrangement and a motor arranged to drive the blade arrangement. The blade arrangement comprises a body having a surface arrangement delimiting a cavity and a plurality of cutting blades extending from the surface arrangement into the cavity.

Abstract: 2D nearest-neighbor quantum architectures for Shor's factoring algorithm may be accomplished using the form of three arithmetic building blocks: modular addition using Gossett's carry-save addition, modular multiplication using Montgomery's method, and non-modular multiplication using an original method. These arithmetic building blocks may assume that ancillae are cheap, that concurrent control may be available and scalable, and that execution time may be the bottleneck. Thus, the arithmetic building blocks may be optimized in favor of circuit width to provide improved depth existing nearest-neighbor implementations.

Abstract: A cleaning method including an alkaline cleaning step followed by an acid cleaning step is used, for example, to treat a newly constructed ultrapure water distribution piping system (using PVDF piping system). The inherent inorganic and organic contaminants in the piping material as well as contaminants deposited (if any) during the construction phase can be removed efficiently. Therefore, the commissioning time of a newly constructed ultrapure water distribution system to meet the specified quality of contaminants can be shortened from several weeks to approximately one week.

Abstract: 2D nearest-neighbor quantum architectures for Shor's factoring algorithm may be accomplished using the form of three arithmetic building blocks: modular addition using Gossett's carry-save addition, modular multiplication using Montgomery's method, and non-modular multiplication using an original method. These arithmetic building blocks may assume that ancillae are cheap, that concurrent control may be available and scalable, and that execution time may be the bottleneck. Thus, the arithmetic building blocks may be optimized in favor of circuit width to provide improved depth existing nearest-neighbor implementations.

Abstract: A slurry supply system with multiple supply modules and a flushing module concurrently coupled to the multiple supply modules is provided. Each supply module includes a slurry reservoir and at least one delivery line connecting to the slurry reservoir, wherein each delivery line is oriented toward a chemical mechanical polishing apparatus. The flushing module includes a flushing liquid reservoir and multiple flushing lines connecting to the flushing liquid reservoir, wherein each flushing line is coupled to each delivery line thereby the flush module can selectively flush one of the delivery lines.

Abstract: Techniques for image browsing, navigating and user interface operation are described herein. An image cube, having three axes representing a medical patient's body parts, imaging technology and image date, may be displayed on a visual display. Image piles of icons or thumbnail images may be positioned within the image cube, according to the three axes. By fixing the body parts axis on a specific body part, an image plane may be selected from the image cube. The selected image plane replaces the image cube in the visual display, including only image piles of the selected body part, organized according to axes indicating imaging technology and image date. An image pile may be selected from the image plane, to replace the image plane on the visual display. Image pile operations allow the user to select from the image pile a desired image(s) for display.

Abstract: A slurry supply system with multiple supply modules and a flushing module concurrently coupled to the multiple supply modules is provided. Each supply module includes a slurry reservoir and at least one delivery line connecting to the slurry reservoir, wherein each delivery line is oriented toward a chemical mechanical polishing apparatus. The flushing module includes a flushing liquid reservoir and multiple flushing lines connecting to the flushing liquid reservoir, wherein each flushing line is coupled to each delivery line thereby the flush module can selectively flush one of the delivery lines.

Abstract: A slurry dispensing system comprises a first supply station, a second supply station, a first loop, a second loop, a first valve and a second valve. The first loop is selectively connected to the first supply station and the second supply station. The second loop is also selectively connected to the first supply station and the second supply station. The first valve connects the first loop to points of use. The second valve connects the second loop to the points of use. When slurry is supplied to the first loop from the first slurry station, slurry is supplied to the second loop from the second slurry station. When the first valve is opened and the second valve is closed, slurry is supplied to the points of use from the first loop.

Abstract: A slurry dispensing system comprises a first supply station, a second supply station, a first loop, a second loop, a first valve and a second valve. The first loop is selectively connected to the first supply station and the second supply station. The second loop is also selectively connected to the first supply station and the second supply station. The first valve connects the first loop to points of use. The second valve connects the second loop to the points of use. When slurry is supplied to the first loop from the first slurry station, slurry is supplied to the second loop from the second slurry station. When the first valve is opened and the second valve is closed, slurry is supplied to the points of use from the first loop.

Abstract: A low cost and long lasting hinge mechanism suitable for hinging a cover to a housing of a device is disclosed. The hinge mechanism has a pair of pins attached to the cover and a corresponding pair of apertures on the housing. The pins fit into the apertures to hinge the cover to the housing to allow the cover to be tilted from a closed position to an open position. The aperture has a first portion and a second constricted portion. A pivoting point is provided on a tab on the housing. A corresponding cam-profiled section is provided on the cover for interacting with the pivoting point to urge the pin into the corresponding constricted portion of the aperture for securing the cover in the open position.

Abstract: The present invention provides polypeptides comprising an immunogenic portion of a M. vaccae soluble protein and DNA molecules encoding such polypeptides, together with methods for their use in the diagnosis and treatment of mycobacterial infection. Methods for enhancing the immune response to an antigen including administration of M. vaccae culture filtrate or delipidated M. vaccae cells are also provided.

Abstract: The present invention provides polypeptides comprising an immunogenic portion of a M. vaccae protein and DNA molecules encoding such polypeptides, together with methods for their use in the diagnosis and treatment of mycobacterial infection. Methods for enhancing the immune response to an antigen including administration of M. vaccae culture filtrate, delipidated M. vaccae cells or delipidated and deglycolipidated M. vaccae cells are also provided.

Abstract: A computer device comprises a casing in which are accommodated an electronic circuit and a touch screen, a protective cover movably arranged on the casing for selectively covering and uncovering at least the touch screen, and a stylus for operating said touch screen. The protective cover includes a compartment which substantially corresponds to the shape of at least part of the stylus and in which the stylus is removably stored, thereby reducing the size of the computer device for more convenient handling of the same by a user.