Abstract: A device configured to administer a medication can comprise a lower housing that includes a housing latch. The device can further comprise a needle guard that is movable relative to the lower housing along a first direction from a first position to a second position so as to expose a needle, and an upper housing supported relative to the lower housing. The upper housing can be configured to move with respect to the lower housing along a second direction from a pre-use position to a dispensed position. The housing latch can releasably interfere with the upper housing when the upper housing is in the pre-use position so as to prevent the upper housing from moving toward the dispensed position, and the movement of the needle guard toward the second position, causes the interference to be removed, thereby allowing the upper housing to move toward the second position.

Abstract: A device configured to administer a medication can comprise a lower housing that includes a housing latch. The device can further comprise a needle guard that is movable relative to the lower housing along a first direction from a first position to a second position so as to expose a needle, and an upper housing supported relative to the lower housing. The upper housing can be configured to move with respect to the lower housing along a second direction from a pre-use position to a dispensed position. The housing latch can releasably interfere with the upper housing when the upper housing is in the pre-use position so as to prevent the upper housing from moving toward the dispensed position, and the movement of the needle guard toward the second position, causes the interference to be removed, thereby allowing the upper housing to move toward the second position.

Abstract: A syringe is disclosed. The syringe comprises a body and a plunger which is moveable between an initial position and a retracted position within, and relative to, the body, wherein the body and plunger define a variable cavity volume within the syringe. The syringe also comprises a locking member configured to lock the plunger in its retracted position relative to the body. Methods and systems for reconstituting a pharmaceutical product are also disclosed. A flexible seal that is fixed to a proximal region of the body of the syringe and has an expanded stretched configuration and a relaxed contracted configuration is also disclosed. The flexible seal may be fixable to a proximal region of the body of the syringe via an end cap, which is configured for removable or fixed attachment to the proximal end of the body.

Abstract: A method of transferring a mixed drug from a drug mixing device in which drug has been mixed to a drug administration device id disclosed. The method comprises the steps of establishing a fluid coupling in an initial configuration between the drug mixing device and the drug administration device to create an assembly comprising the drug mixing device and drug administration device, wherein the drug administration device is located above the drug mixing device. The method includes the step of inverting the assembly to position it in an inverted configuration such that the drug administration device is located below the drug mixing device. The method includes the step of causing a flow of the mixed drug from the drug mixing device to the drug administration device when the assembly is in the inverted configuration.

Abstract: A drug mixing device is disclosed. The drug mixing device comprises a first container for holding a fluid component of a drug to be mixed and a second container, and a transfer member configured to provide a fluid pathway between the first container and the second container. The transfer member is configured to minimise the hydraulic resistance to the movement of the fluid component when the fluid component flows from the first container to the second container.

Abstract: A drug mixing device is disclosed. The drug mixing device comprises a transfer member, comprising an aperture for dispensing a fluid, wherein the fluid is a first component of a drug to be mixed. The drug mixing device also comprises a container for containing a second component of the drug to be mixed, the container comprising a surface. The aperture is configured to determine the initial direction of the velocity of the fluid dispensed through the aperture and further configured to direct the dispensed fluid towards the surface. The aperture and the surface are arranged relative to each other to cooperate such that, in use, substantially all of the dispensed fluid initially encounters the surface at an oblique angle.

Abstract: A drug mixing device is disclosed. The drug mixing device comprises a movable actuator, wherein movement of the actuator causes mixing of a drug within the drug mixing device; and an elastic member coupled to the actuator. The elastic member is configured upon release to transition from an extended state to a non-extended state, the elastic member storing energy in the extended state. The movement of the actuator is driven by the release of the stored energy as the elastic member transitions from the extended state towards the non-extended state.

Abstract: A drug mixing device is disclosed. The drug mixing device comprises a first container for holding a first component of a drug to be mixed; and a housing. The housing comprises a first port configured to receive the first container and a second port configured such that the second port is unable to receive the first container. The first container is configured to be detachably coupled to the housing.

Abstract: A drug mixing device is disclosed. The drug mixing device comprises a container for containing a fluid component of a drug to be mixed and a housing. The housing comprises an inlet aperture configured to be connected to a fluid driver for driving a driving fluid into the container and an outlet aperture configured to permit the fluid component of the drug to be mixed to leave the container. The apertures are arranged such that the driving fluid enters the container through the inlet aperture, and additionally arranged such that the fluid component exits the container through the outlet aperture, the driving fluid having a lower density than the fluid component. The inlet aperture and the outlet aperture are arranged such that, in use, the inlet aperture is located above the outlet aperture.

Abstract: A drug mixing device is disclosed. The drug mixing device comprises a first container for holding a first component of a drug to be mixed, a second container for holding a second component of the drug to be mixed, fluidly coupled to the first container; and a fluid driver fluidly coupled to the first container and configured to drive a driving fluid into the first container. The mixing device is arranged such that, in use, when the fluid driver drives the driving fluid into the first container, at least some of the first component of the drug to be mixed flows to the second container.

Abstract: A drug mixing device is disclosed. The drug mixing device comprises an actuator configured to cause automatic mixing of a first component of a drug to be mixed with a second component of a drug to be mixed; and a trigger, configured to be actuated by a user, to cause the actuator to commence mixing.

Abstract: A drug mixing device is disclosed. The drug mixing device comprises an actuator configured to cause mixing of a first component of a drug with a second component of the drug; and a locking mechanism, having a locked state and a unlocked state. The actuation of the actuator is prevented when the locking mechanism is in the locked state and the actuation of the actuator is permitted when the locking mechanism is in the unlocked state. The locking mechanism is configured to adopt the unlocked state only when the mixing device is oriented in a specific orientation.

Abstract: A device configured to administer a medication can comprise a lower housing that includes a housing latch. The device can further comprise a needle guard that is movable relative to the lower housing along a first direction from a first position to a second position so as to expose a needle, and an upper housing supported relative to the lower housing. The upper housing can be configured to move with respect to the lower housing along a second direction from a pre-use position to a dispensed position. The housing latch can releasably interfere with the upper housing when the upper housing is in the pre-use position so as to prevent the upper housing from moving toward the dispensed position, and the movement of the needle guard toward the second position, causes the interference to be removed, thereby allowing the upper housing to move toward the second position.

Abstract: A device configured to administer a medication can comprise a lower housing that includes a housing latch. The device can further comprise a needle guard that is movable relative to the lower housing along a first direction from a first position to a second position so as to expose a needle, and an upper housing supported relative to the lower housing. The upper housing can be configured to move with respect to the lower housing along a second direction from a pre-use position to a dispensed position. The housing latch can releasably interfere with the upper housing when the upper housing is in the pre-use position so as to prevent the upper housing from moving toward the dispensed position, and the movement of the needle guard toward the second position, causes the interference to be removed, thereby allowing the upper housing to move toward the second position.

Abstract: A device configured to administer a medication can comprise a lower housing that includes a housing latch. The device can further comprise a needle guard that is movable relative to the lower housing along a first direction from a first position to a second position so as to expose a needle, and an upper housing supported relative to the lower housing. The upper housing can be configured to move with respect to the lower housing along a second direction from a pre-use position to a dispensed position. The housing latch can releasably interfere with the upper housing when the upper housing is in the pre-use position so as to prevent the upper housing from moving toward the dispensed position, and the movement of the needle guard toward the second position, causes the interference to be removed, thereby allowing the upper housing to move toward the second position.

Abstract: A device configured to administer a medication can comprise a lower housing that includes a housing latch. The device can further comprise a needle guard that is movable relative to the lower housing along a first direction from a first position to a second position so as to expose a needle, and an upper housing supported relative to the lower housing. The upper housing can be configured to move with respect to the lower housing along a second direction from a pre-use position to a dispensed position. The housing latch can releasably interfere with the upper housing when the upper housing is in the pre-use position so as to prevent the upper housing from moving toward the dispensed position, and the movement of the needle guard toward the second position, causes the interference to be removed, thereby allowing the upper housing to move toward the second position.

Abstract: A device configured to administer a medication can comprise a lower housing that includes a housing latch. The device can further comprise a needle guard that is movable relative to the lower housing along a first direction from a first position to a second position so as to expose a needle, and an upper housing supported relative to the lower housing. The upper housing can be configured to move with respect to the lower housing along a second direction from a pre-use position to a dispensed position. The housing latch can releasably interfere with the upper housing when the upper housing is in the pre-use position so as to prevent the upper housing from moving toward the dispensed position, and the movement of the needle guard toward the second position, causes the interference to be removed, thereby allowing the upper housing to move toward the second position.

Abstract: An infusion device comprising an infuser base, a cannula and a ferrule. The infuser base having a bore extending therethrough, the bore having distal and proximal ends and defining a shoulder therebetween. The cannula having distal and proximal ends, the proximal end having an inside first diameter. A flange extends radially outward from the cannula proximal end. The cannula is positioned in the bore such that the flange is positioned adjacent the shoulder. The ferrule has an insertion portion, having an outside second diameter which is substantially equal to the first diameter, and a tapered portion extending from the insertion portion. The ferrule is positioned in the bore such that the insertion portion and a portion of the tapered portion are received in the cannula proximal end and the flange is compressed between the shoulder and the tapered portion to define a seal between the cannula and ferrule.

Abstract: Instrument for creating voids and channels in bone; and for obtaining samples of bone tissue. The instruments are suitable for reducing fractures in bone and for compacting the bone to create a barrier for leakage upon material injection. The instruments may also be used for bone biopsy and for obtaining samples of bone tissue. Methods for using these instruments are also disclosed.

Abstract: A surgical introducer sheath comprising a first member having a first longitudinally extending lumen dimensioned to receive a surgical instrument therethrough, a second member having a second longitudinally extending lumen dimensioned to receive the first member, and a retainer adjacent a distal portion of the second member movable from a first retracted position to a second extended position to limit proximal movement of the introducer sheath. Rotational movement of the second member in a first direction moves the retainer to the extended position and rotational movement of the second member in a second direction moves the retainer to a retracted position.