Abstract: Provided herein are purification, production and manufacturing methods for recombinant viral vector particles such as recombinant adeno-associated viral (rAAV) vector particles substantially free of empty viral particles; a population of recombinant adeno-associated vims (rAAV) particles purified using the method described herein, and a pharmaceutical composition comprising the purified rAAV.

Abstract: Embodiments of an alarm system are described, which may be mounted or built-in to a bicycle or other device which is in need of anti-theft protection. A loud alarm is connected to or mounted in the protected device, and is operatively connected to either or both: a lock that anchors the device to a stationary object, and/or parts of the protected device that might be stolen or vandalized. The alarm unit is built and wired in such a way that the lock or parts of the protected device may not be significantly tampered with or removed without triggering the alarm. Externally-mounted alarm units preferably include a weather-proof casing, which contains a unique clamping feature that makes the alarm tamper-resistant or tamper-proof. The alarm casing may contain a sound chamber that preferably amplifies the alarm sound, waterproofs the alarm component, and prevents a thief from muffling the sound.

Abstract: Embodiments of an alarm system are described, which may be mounted or built-in to a bicycle or other device which is in need of anti-theft protection. A loud alarm is connected to or mounted in the protected device, and is operatively connected to either or both: a lock that anchors the device to a stationary object, and/or parts of the protected device that might be stolen or vandalized. The alarm unit is built and wired in such a way that the lock or parts of the protected device may not be significantly tampered with or removed without triggering the alarm. Externally-mounted alarm units preferably include a weather-proof casing, which contains a unique clamping feature that makes the alarm tamper-resistant or tamper-proof. The alarm casing may contain a sound chamber that preferably amplifies the alarm sound, waterproofs the alarm component, and prevents a thief from muffling the sound.

Abstract: Embodiments of an alarm system are described, which may be mounted or built-in to a bicycle or other device which is in need of anti-theft protection. A loud alarm is connected to or mounted in the protected device, and is operatively connected to either or both: a lock that anchors the device to a stationary object, and/or parts of the protected device that might be stolen or vandalized. The alarm unit is built and wired in such a way that the lock or parts of the protected device may not be significantly tampered with or removed without triggering the alarm. For example, the alarm system is adapted to sound if a bicycle lock is tampered with or if sensors transmit that a bicycle part is being moved or tampered with. Externally-mounted alarm units preferably include a weather-proof casing, which contains a unique clamping feature that makes the alarm tamper-resistant or tamper-proof.