Abstract: An artificial reality environment (XRE) schema is defined that supports anel-controlling interactions between various artificial reality actors. The XRE schema includes a set of definitions for an XRE, independent of type of artificial reality device. The definitions in the XRE schema can include standards for both interfaces and data objects. The XRE schema can define XR elements in terms of entities and components of a space, organized according to a hierarchy. Each entity can represent a real or virtual object or space, within the XRE, defined by a name and a collection of one or more components. Each component (as part of an entity) can define aspects and expose information about the entity. The XRE schema can specify structures that that allow actors (e.g., producers, instantiators, and consumers) to define and perform actions in relation to XRE elements.

Abstract: The present disclosure provides a method of cell sedimentation and retention of target cells, for example circulating tumour cells, CTC, from a fluid sample onto a solid support. The method comprises placing a fluid medium comprising the target cells in a fluid chamber, the fluid chamber having an open end sealed against a surface of the solid support. The method further comprises subjecting the fluid medium to centrifugation within the fluid chamber to induce sedimentation of the target cells and promote cell adhesion to the surface of the solid support. The method further comprises, post-centrifugation, positioning a fluid absorbing element in the fluid chamber to remove fluid from the fluid chamber. The method further comprises controlling a flow rate of the fluid being absorbed by the fluid absorbing element such that the sedimented cells are not detached from the surface of the solid support.

Abstract: In particular embodiments, a computing system may capture access a set of depth measurements and an image of a scene generated using one or more sensors of an artificial reality device. The system may generate, based on the image, a plurality of segmentation masks respectively associated with a plurality of object types. The system may segment, using the plurality of segmentation masks, the set of depth measurements into subsets of depth measurements respectively associated with the plurality of object types. The system may determine, for each object type, a three-dimensional (3D) model that best fits the subset of depth measurements corresponding to the object type. The system may refine, using 3D models determined for the plurality of object types, the subsets of depth measurements respectively associated with the plurality of object types and use refined depth measurements for mixed reality rendering.

Abstract: In one embodiment, a method by a computing system comprising a color camera and two monochrome cameras respectively associated with two eyes of a user includes computing a point cloud corresponding to a visible environment based at least on two stereoscopic grayscale images respectively captured by the two monochrome cameras, generating a mesh corresponding to the visible environment based on the computed point cloud, and generating two stereoscopic colorized images to be respectively displayed to the two eyes of the user, where each of the two stereoscopic colorized images is generated using (1) the mesh, (2) luminance information from one of the two stereoscopic grayscale images that is associated with the eye to which the stereoscopic colorized image is to be displayed, and (3) color information from a color input image captured by the color camera.

Abstract: A system includes a processor and a memory in communication with the processor that includes a path planning module. The path planning module causes the processor to determine a nominal driving path for a leading vehicle and a following vehicle that follows the leading vehicle and identify an obstacle in an external environment that prevents one of the leading vehicle and the following vehicle from utilizing the nominal driving path. In response to identifying the obstacle, the path planning module causes the processor to determine an alternate driving path for one of the leading vehicle and the following vehicle that avoids the obstacle and operate the leading vehicle and the following vehicle such that one of the leading vehicle and the following vehicle that is prevented from utilizing the nominal driving path due to the obstacle utilizes the alternate driving path and the other utilizes the nominal driving path.

Abstract: The present disclosure provides a method of cell sedimentation and retention of target cells, for example circulating tumour cells, CTC, from a fluid sample onto a solid support. The method comprises placing a fluid medium comprising the target cells in a fluid chamber, the fluid chamber having an open end sealed against a surface of the solid support. The method further comprises subjecting the fluid medium to centrifugation within the fluid chamber to induce sedimentation of the target cells and promote cell adhesion to the surface of the solid support. The method further comprises, post-centrifugation, positioning a fluid absorbing element in the fluid chamber to remove fluid from the fluid chamber. The method further comprises controlling a flow rate of the fluid being absorbed by the fluid absorbing element such that the sedimented cells are not detached from the surface of the solid support.

Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

Abstract: Systems, methods, and other embodiments described herein relate to navigating a trailer after the physical connection between a vehicle and trailer disconnects. In one embodiment, a method includes responsive to determining that a physical connection between a vehicle and a trailer has disconnected, determining trajectory information for navigating the trailer without a connection to the vehicle. The method includes communicating the trajectory information to the trailer to cause the trailer to follow a trajectory associated with the vehicle. The method includes monitoring whether the trailer is following the trajectory.

Abstract: Systems, methods, and other embodiments described herein relate to controlling a trailer without the presence of a physical connection. In one embodiment, a method includes in response to receiving a signal to initiate hitchless maneuvering of a trailer separately from a controlling vehicle, acquiring control inputs to maneuver the trailer from an input device within the controlling vehicle. The method includes communicating, from the controlling vehicle to the trailer, the control inputs to maneuver the trailer. The method includes in response to receiving feedback from the trailer indicating the trailer is within a requested position, sending a control signal to stop the trailer.

Abstract: A conductive transfer for application to a surface of a wearable item comprises a first non-conductive ink layer and a second non-conductive ink layer. An electrically conductive layer is positioned between the first non-conductive ink layer and the second non-conductive ink layer. The conductive transfer also comprises an adhesive layer for adhering the conductive transfer to the surface of the wearable item. The adhesive layer comprises a larger cross-sectional area than the cross-sectional area of each of the first non-conductive ink layer, the second non-conductive ink layer and the electrically conductive layer.

Abstract: The present disclosure provides a cell harvesting method for the efficient sedimentation and retention of cells from liquid samples onto a solid support with low cell losses and low impact on cell morphology.

Abstract: The present disclosure provides a cell harvesting method and device for the efficient sedimentation and retention of cells from liquid samples onto a solid support with low cell losses and low impact on cell morphology. The device has two configurations, one being for use in a centrifuge to centrifuge the sample, a second for controlled release of the liquid post centrifugation. The device includes a base to hold a solid support that receives cells on a top surface thereof that releasably holds a fluid chamber which has a first opening with a gasket surrounding the opening with that bears against a top surface of the support. An opening receives the liquid sample and the gasket defines an area into which the targeted cells deposit. A first cap closes the second opening during centrifugation.

Abstract: Aspects of the present disclosure are directed to defining an artificial reality environment (XRE) and controlling interactions between various artificial reality actors with a defined XRE schema. The XRE schema includes a set of definitions for an XRE, independent of type of artificial reality device. The definitions in the XRE schema can include standards for both interfaces and data objects. The XRE schema can define XR elements in terms of entities and components of a space, organized according to a hierarchy. Each entity can represent a real or virtual object or space, within the XRE, defined by a name and a collection of one or more components. Each component (as part of an entity) can define aspects and expose information about the entity. The XRE schema can specify structures that that allow actors (e.g., producers, instantiators, and consumers) to define and perform actions in relation to XRE elements.

Abstract: A conductive transfer for application to an article comprises first and second non-conductive layers and a conductive layer positioned between the two non-conductive layers. The conductive transfer further comprises an adhesive layer for adhering the conductive transfer to an article, such as a wearable item. The conductive layer comprises a plurality of tessellated cells defined by a printed conductive ink. The conductive layer comprises a main element and an input track with the plurality of tessellated cells being comprised over the input track of said conductive layer.

Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

Abstract: The present disclosure provides a cell harvesting method and device for the efficient sedimentation and retention of cells from liquid samples onto a solid support with low cell losses and low impact on cell morphology. The device has two configurations, one being for use in a centrifuge to centrifuge the sample, a second for controlled release of the liquid post centrifugation. The device includes a base to hold a solid support that receives cells on a top surface thereof that releasably holds a fluid chamber which has a first opening with a gasket surrounding the opening with that bears against a top surface of the support. An opening receives the liquid sample and the gasket defines an area into which the targeted cells deposit. A first cap closes the second opening during centrifugation.

Abstract: In one embodiment for generating passthrough, a computing system may access images of an environment captured by cameras of a device worn by a user. The system may generate, based on the images, depth measurements of objects in the environment. The system may generate a mesh covering a field of view of the user and then update the mesh based on the depth measurements to represent a contour of the objects in the environment. The system may determine a first viewpoint of a first eye of the user and render a first output image based on the first viewpoint and the updated mesh. The system may then display the first output image on a first display of the device, the first display being configured to be viewed by the first eye of the user.

Abstract: A conductive transfer and method of producing the conductive transfer is described. The conductive transfer comprises two non-conductive layers and a conductive layer between the two non-conductive layers and at least one electrical component in electrical communication with the conductive layer. The conductive layer includes a power trace for providing a power source to the electrical component and a data trace for providing the electrical component with an electrical signal.

Abstract: A conductive transfer for application to an article comprises first and second non-conductive layers and a conductive layer positioned between the two non-conductive layers. The conductive transfer further comprises an adhesive layer for adhering the conductive transfer to an article, such as a wearable item. The conductive layer comprises a plurality of tessellated cells defined by a printed conductive ink. The conductive layer comprises a main element and an input track with the plurality of tessellated cells being comprised over the input track of said conductive layer.

Abstract: Dynamic key cryptography validates mobile device users to cloud services by uniquely identifying the user's electronic device using a very wide range of hardware, firmware, and software minutiae, user secrets, and user biometric values found in or collected by the device. Processes for uniquely identifying and validating the device include: selecting a subset of minutia from a plurality of minutia types; computing a challenge from which the user device can form a response based on the selected combination of minutia; computing a set of pre-processed responses that covers a range of all actual responses possible to be received from the device if the combination of the particular device with the device's collected actual values of minutia is valid; receiving an actual response to the challenge from the device; determining whether the actual response matches any of the pre-processed responses; and providing validation, enabling authentication, data protection, and digital signatures.