Abstract: The present disclosure provides methods of generating supports (e.g., beads) comprising barcode molecules coupled thereto. A barcode molecule coupled to a support may comprise a barcode sequence and a functional sequence. A barcode molecule may be generated using two or more ligation reactions in a combinatorial fashion. A support comprising two or more different barcode molecules may be useful for analyzing or processing one or more analytes such as nucleic acid molecules, proteins, and/or perturbation agents.

Abstract: The present disclosure provides a class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: (see Formula I structure) wherein variables R1, R1?, R2, R2?, R3, R4, R5, R6, R7, and b of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A? plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, and other central nervous system conditions.

Abstract: Multispecific antibodies binding to human CD40 and human CD137, methods for preparing such multispecific antibodies, and methods of using such multispecific antibodies for therapeutic or other purposes.

Abstract: A floor cleaner including a vacuum source, a base having a suction inlet, a body pivotally coupled to the base, a handle that extends from the body. The floor cleaner further includes an upper end, the handle adjacent the upper end, a lower end opposite the upper end, the base adjacent the lower end, a front side, the suction inlet adjacent the front side, a back side opposite the front side, a battery that powers the vacuum source, the battery adjacent the back side, a supply tank configured to store a cleaning fluid, the supply tank adjacent the back side, and a recovery tank configured to store the cleaning fluid drawn through the suction inlet from the surface by the vacuum source, the recovery tank adjacent the front side.

Abstract: An improved system and method for recognizing an audio signal due to physical activity and taking a predetermined action in response is disclosed. A “reverse noise signal” created by the sound pressure wave of the physical activity acting on the earpiece transducer is obtained. In some embodiments, an ambient noise signal is inverted and fed back, and the inverted signal is added to the intended audio signal being sent to the earpiece so that the ambient noise is cancelled. In other embodiments, a processor receives the ambient noise signal and predicts the modification to the intended audio signal needed to counteract the ambient noise. In other embodiments, the reverse noise signal may represent a motor or biological activity of a user; the system may take different actions in response to different physical activities, such as a heart beat of the user, or a tap, footfall, or swallowing by the user.

Abstract: A floor cleaner including a vacuum source recovery tank or collection bin and a body pivotally coupled to a base. The body is pivotable between an upright storage position and an inclined operating position and the body includes a recovery tank recess. The floor cleaner further includes a recovery tank removably coupled to the body in the recovery tank recess, the recovery tank in fluid communication with a vacuum source and a suction inlet, the recovery tank configured to store the cleaning fluid and/or debris drawn through the suction inlet from a surface by the vacuum source. The floor cleaner further includes a projection and a recess that receives the projection when the recovery tank is coupled to the body to limit movement of the body relative to the recovery tank.

Abstract: A method for identifying minerals and other materials illuminates a mineral with monochromatic light for an illumination duration and collects scattered light using a Raman spectrometer detector and an aggregated or average Raman spectrum data is determined. True Raman spectrum data is determined by subtracting a blank spectrum. The true Raman spectrum data is compared to reference spectrums to identify the mineral or material. A display or output of one or more of: (a) a name and/or chemical composition of one or more identified minerals; (b) the true Raman spectrum data; and (c) the one or more reference spectrums; are provided. The monochromatic light preferably has a wavelength in the range of about 400 nm to about 425 nm and the Raman spectrometer detector is adapted to detect a Raman-shift range of about 100 cm?1 to about 1400 cm?1.

Abstract: A pellicle suitable for use with a patterning device for a lithographic apparatus. The pellicle comprising at least one breakage region which is configured to preferentially break, during normal use in a lithographic apparatus, prior to breakage of remaining regions of the pellicle. At least one breakage region comprises a region of the pellicle which has a reduced thickness when compared to surrounding regions of the pellicle.

Abstract: Embodiments for using an intelligent hearing aid device by a processor. Audio data may be received and analyzed for a user according to a plurality of user preferences and interests, historical activity patterns of the user, or a combination thereof. One or more hearing assistive actions may be performed in relation to the audio data to facilitate hearing according to the plurality of user preferences and interests, historical activity patterns of the user, or a combination thereof.

Abstract: This application discloses thin metal strips and methods of making thin metal strip. Particular embodiments of such methods include cooling the thin metal strip to a temperature equal to or less than a bainite or a martensite start transformation temperature BS or MS to thereby form bainite and/or martensite, respectively, within the thin metal strip, reheating the thin metal strip to a reheat temperature equal to or greater than transformation temperature Ac3 and holding the thin metal strip at the reheat temperature for at least 2 seconds and thereby forming austenite within the thin metal strip with at least 75% of austenite grains having a grain size equal to or less than 15 ?m, and rapidly recooling the thin metal strip to a temperature equal to or less than the martensite start transformation temperature MS and thereby providing finer martensite within the thin metal strip from a finer prior austenite.

Abstract: Higher isolation solutions for printed circuit board mounted antenna and waveguide interfaces are provided herein. An example waveguide mounted onto a dielectric substrate can enclose around a periphery of an antenna and contain radiation produced by the antenna along a path that is coaxial with a centerline of the waveguide. The waveguide can have a first portion having a first cross sectional area that is substantially polygonal that transitions to a second cross sectional area that is substantially conical. A shape of the radiation produced by the antenna is altered by the first portion as the radiation propagates through the first portion.

Abstract: Methods provide for creating a three-dimensional random fiber orientation in a composite component. According to embodiments described herein, narrow flakes are created from a unidirectional composite fiber tape and poured into a reservoir of a mold, creating a three-dimensional random fiber orientation of the narrow flakes within the reservoir. At least a majority of the narrow flakes have an aspect ratio of length to width of at least 6:1. The narrow flakes are heated and compressed to fill the mold and create the composite component. The three-dimensional random fiber orientation of the narrow flakes within the reservoir is maintained as the narrow flakes are pushed through the mold, creating consistent, uniform strength characteristics throughout the resulting composite component.

Abstract: Methods and systems for providing user defined content transmissions are disclosed. An example method can comprise receiving a request for first content and receiving a first preference. First content can be retrieved from a first source based on the request for first content. Second content can be retrieved from a second source based on the first preference. The first content and second content can be packaged for transmission in response to receiving the request and the first preference.

Abstract: A method, computer system, and a computer program product for intelligently synchronizing exercise music for an instructor based group workout is provided. The present invention may include identifying at least one goal workout. The present invention may then include receiving a plurality of verbal cues associated with an instructor and a plurality of nonverbal cues associated with the instructor. The present invention may also include analyzing the received plurality of verbal cues and the received plurality of nonverbal cues. The present invention may further include generating the exercise music based on the analyzed plurality of verbal cues and analyzed plurality of nonverbal cues.

Abstract: A method for operating a paving machine is provided. The paving machine includes a screed assembly, a washdown system for washing the paving machine and the screed assembly and a ventilation system. The method includes receiving, by a controller, an operational data associated with the paving machine, and determining an operational state associated with the washdown system. The method further includes controlling, by the controller, an operation of the ventilation system based on the operational data associated with the paving machine and the operational state associated with the washdown system.

Abstract: A circuit includes a bitcell array having a plurality of bitlines, and an I/O functional unit to read data stored in the bitcell array. The I/O functional unit includes a first multiplexer to select a first input port or a first bitline among a first group of bitlines, a first latch to latch the output of the first multiplexer, a second multiplexer to select a second input port or a second bitline among a second group of bitlines. The second input port is coupled to an output port of the first latch. The I/O functional unit further includes a second latch to latch the output of the second multiplexer.

Abstract: A cooling structure for large electronic boards with closely-spaced heterogeneous die and packages is disclosed. The assembly includes a frame having a plurality of openings. The assembly further includes a cold plate mounted to the frame. The cold plate includes at least one inlet and at least one outlet and fluid channels in communication with the at least one inlet and the at least one outlet. The assembly further includes a heat sink mounted within each of the plurality of openings which in combination with sidewalls of the openings of the frame and the cold plate form individual compartments each of which are in fluid communication with the fluid channels.

Abstract: A floor cleaner includes a base movable over the surface to be cleaned. The base includes a front side, a back side opposite the front side, a lower end configured to be adjacent the surface to be cleaned, a suction inlet adjacent the front side and adjacent the lower end of the base and in fluid communication with a vacuum source, a brushroll rotatable about a brushroll axis, a squeegee that contacts the brushroll, the squeegee between the front side of the base and the brushroll axis. The base further includes a suction conduit between the brushroll and the back side of the base and a flow channel formed by a recesses that extends along the brushroll axis adjacent the suction conduit. The flow channel defines an edge that contacts the brushroll.

Abstract: Various methods and systems are provided for an oil filter system for a vehicle system. In one example, an oil filter system comprises a housing within which a plurality of oil filter elements are disposed and a frame supporting the housing, the frame including one or more mountings configured to support one or more vehicle sub-assemblies.

Abstract: A segmented headliner includes a plurality of segments connected together and outlining a central opening.