Abstract: Described herein are pyrimidinyl-pyridyloxy-naphthyl compounds with inositol requiring enzyme 1 (IRE1) modulation activity or function having the Formula I or I? structure: or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I or I? compounds, as well as methods of using such IRE1 modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract: A computer implemented method is provided for creating a regular expression for extracting data from a data set. The method comprises the steps of: identifying a first common substring, the first common substring being present in at least two data entry strings of a first data set, by comparing a first and second data entry string of the first data set; and creating a first regular expression for extracting data from a second data set, the first regular expression including a first part for matching the first common substring.

Abstract: Techniques and arrangements for dynamically modifying a cardholder verification method (CVM) implemented at a point-of-sale (POS) device. In some instances, the techniques instruct a POS device to determine an attribute associated with a received payment instrument and determine, based on this information and via the issuing entity, whether to implement a default or static CVM or whether to apply a modified or dynamic CVM such that the POS device requests different verification information than if the POS device did not modify the CVM. The modified or dynamic CVM may be implemented if a customer's device, present at the location of the payment transaction, has installed thereon an application of the entity that has issued the payment instrument.

Abstract: A proton beam therapy system with a cantilever gantry. The cantilever gantry has one end portion (the fixed end portion) affixed to an external structure that supports the weight of the gantry. The remainder of the gantry is suspended and the free end portion is coupled to a beam nozzle. A main bearing is coupled to the fixed end portion and enables the gantry to rotate in a full range of 360° around the iso-center. A large counterweight can be disposed in the fixed end portion to keep the system center of mass close to the bearing. The gantry may have a monocoque housing, including a cantilever section enclosing the magnets and other components of the gantry beamline and a drum section on which the bearing is placed.

Abstract: A vehicle includes a side mirror positioned on an A-pillar. A light assembly is coupled with a bottom surface of the side mirror. The light assembly is configured to illuminate a plurality of photoluminescent structures located within an interior and on an exterior of the vehicle when the vehicle is in a door off configuration.

Abstract: An instrument is applied to body tissue of a body part to produce vibration to thereby reduce pain of injection or other pain producing stimulus. The device has a frame, and a source of vibration connected to the frame. A removable tip is connectable to the frame which has a distal end that is connected to the source of vibration when the tip is connected to the frame, to thereby vibrate the distal end when the source of vibration is activated. At the distal end of the tip are mutually facing arms which define an opening between them. Each arm forms a projection which extends at an angle from the arm. The projections are shaped to fit the body part so that the arms and projections are sized and dimensioned to position, retain, and transmit vibration to the body part in a position proximate the opening.

Abstract: A wellbore assembly includes a conveyance member including at least one of a continuous spooled rod, a wireline, and a slickline; an accumulator system connected to the conveyance member; and a setting tool connected to the accumulator system. The accumulator system may be configured to supply a fluid pressure to actuate the setting tool. A method of operating a wellbore tool includes lowering a wellbore assembly into a wellbore using a conveyance member including at least one of a continuous spooled rod, a wireline, and a slickline, wherein the wellbore assembly includes an accumulator system and a setting tool. The method includes actuating the accumulator system to provide a fluid pressure to the setting tool. The method also includes actuating the setting tool using the fluid pressure.

Abstract: A computer detects and identifies a consumer contacting a virtual dialogue host. The computer receives a query from the consumer and determines an estimated wait time to be connected to a representative. The computer determines whether additional information would be helpful in resolving the consumer query and, if so, requests that information. The computer proceeds to extract other information from the user during the remaining estimated wait time and aggregates the results.

Abstract: Disclosed are novel branched amphiphilic lipids, in particular novel branched amphiphilic lipids of general formula (II). Also disclosed is a method of synthesis for the compounds of formula (II), from unsaturated amphiphilic compounds of general formula (I). Further disclosed is the use of the compounds of general formula (II) and of the lipoplexes obtained by formulation of the compounds of general formula (II) for applications, particularly transfection, in which improved fusion properties are desired.

Abstract: A proximity switch and moisture sensing assembly includes a vehicle window and a proximity switch including a proximity sensor located on the window and providing an activation field. The proximity switch and moisture sensing assembly also includes control circuitry monitoring a signal responsive to the activation field, determining a switch activation based on the signal, and determining a moisture value based upon the signal. A conductive shield may be disposed between the proximity sensors and the outside environment to reduce the effects of moisture on the outer side of the window.

Abstract: A method (e.g. high resolution melting analysis) of determining of the presence or absence of a target nucleic acid in a sample, e.g. a biological sample, the method comprising steps of:?(a) contacting the sample with a composition comprising?(i) a quaternary ammonium compound, e.g. 3-(trimethoxysilyl) propyl-dimethyl octadecyl ammonium chloride (3-TPAC) or a precursor thereof, in order to release the nucleic acids from said sample; and?(b) contacting the sample with a probe which is capable of inter-acting with the nucleic acid sequence; and?(c) observing and/or measuring a property of the sample, e.g. fluorescence from a dsDNA binding dye.

Abstract: Methods and systems for managing a premises are disclosed. An interface device and a premises system may be located at the premises. The interface device may receive a signal from a premises device of the premises system. An indication of the premises device may be output via a user interface. Configuration information may be associated with the premises device. The interface may monitor and control the premises device.

Abstract: Systems and methods described herein relate to computer-implemented processing of information, data, and database identifiers involving content and/or database constructs regarding experiences. According to one exemplary implementation, an illustrative method of computerized information processing may involve handling and/or processing data regarding a product, where the product may be an experience represented by and automatically processed via one or more computer systems, platforms, and/or GUIs as a function of product identifiers and/or Boolean flags.

Abstract: A discrete and safe automated insect monitoring system includes a housing, an interior chamber within the housing, and a light source arranged within the housing to illuminate at least a portion of a floor surface of the interior chamber. A multi-pixel optical sensor is arranged within the housing so that a field of view of the sensor comprehends a substantial portion of the floor surface. A processing circuit arranged within the housing receives optical data from the multi-pixel optical sensor, analyzes the optical data to detect the intrusion of an insect or other object into the interior chamber by comparing most recently received optical data to previously received optical data, and generates an indication in response to detecting the intrusion of an insect or other object. Detection and/or classification results can be wirelessly forwarded to another device, to alert appropriate personnel.

Abstract: Embodiments of the present disclosure generally relate to cables having routing features integrated with a jacket of the cable, and methods of using and forming the same. The routing features include one or more of hook-and-loop fasteners or clips for securing adjacent cables to one another and/or to a mounting structure, such as a server rack. Methods described herein include securing cables to one another using routing retention features integrated with cable jackets, and forming jackets having routing retention features.

Abstract: Described is an approach for an improved method, system, and computer program product that performs zero-knowledge proof of knowledge of user identification and/or authentication for a decentralized, trustless storage and management of user identification and/or authentication using one or more distributed ledger systems.

Abstract: The present invention provides a process for the preparation of a (hydro)(chloro)fluoroalkene by contacting a reagent stream comprising a hydrochlorofluoroalkane with a catalyst in a reactor to dehydrochlorinate at least a portion of the hydrochlorofluoroalkane to produce a product stream comprising the (hydro)(chloro)fluoroalkene and hydrogen chloride (HCl), wherein the catalyst is selected from the group consisting of metal oxide catalysts, metal halide catalysts, zero-valent metal catalysts, carbon-based catalysts and mixtures thereof, and wherein (i) the catalyst is chlorinated prior to contacting it with the reagent stream comprising the hydrochlorofluoroalkane; and/or (ii) the contacting step is carried out in the presence of a HCl co-feed.

Abstract: A system for protecting electronic headset components from sunlight is provided. The headset is secured to a user's head for use and includes an electronic display, a lens, and a battery all secured to a frame structure. The frame structure includes a mask portion which is sized and shaped to fit snugly against the user's face, and a strap for holding the mask to the face. According to the invention, a moveable shield is mounted to a portion of the frame structure, either directly or indirectly, and is designed to move between a stowed position, wherein light from the display may pass freely through the lens to the user's eyes, during use, and a blocking position, wherein sunlight is prevented from passing through the lens and reaching, and damaging, the delicate electronic display. The shield may be sized and shaped to fit both lenses, or each lens, and may pivot or slide between positions, either automatically, or manually.

Abstract: A computer detects and identifies a consumer contacting a virtual dialogue host. The computer receives a query from the consumer and determines an estimated wait time to be connected to a representative. The computer determines whether additional information would be helpful in resolving the consumer query and, if so, requests that information. The computer proceeds to extract other information from the user during the remaining estimated wait time and aggregates the results.

Abstract: Disclosed is a stage system and metrology apparatus comprising at least one such stage system. The stage system comprises a stage carrier for holding an object and a stage carrier positioning actuator for displacing the stage carrier. The stage system also comprises a balance mass to counteract a displacement of the stage carrier, and a balance mass positioning actuator for displacing the balance mass. A cable arrangement is connected to the stage carrier for the supply of at least power to said stage carrier. The stage system is operable to apply a compensatory feed-forward force to the balance mass which compensates for a cable arrangement force exerted by the cable arrangement.