Publication number: 20150196352
Abstract: In various embodiments, a surgical instrument is provided that may comprise an end effector for performing a surgical procedure on tissue, for example. The end effector may comprise at least one energy delivery surface and heat dissipation means for dissipating heat from at least a portion of the end effector. For example, in at least one embodiment, the end effector may comprise a first jaw, a second jaw, and a cutting member. The cutting member may comprise a cutting surface and a body, which may define a cavity and at least one opening communicating with the cavity. A fluid may be moved through the cavity to and/or from the opening(s). Additionally, in at least one embodiment, a surgical instrument's end effector may comprise a first jaw, a second jaw, a cutting member, and at least one heat pipe. Various other heat dissipation means are also disclosed.
Type:
Application
Filed:
March 20, 2015
Publication date:
July 16, 2015
Inventors:
Andrew T. Beckman, Bradley E. White, Cory G. Kimball, John F. Cummings, Al Mirel, Christopher J. Schall, Jeffrey L. Aldridge, Timothy G. Dietz, David A. Witt, Mary E. Mootoo, Zhifan F. Huang, Raymond M. Banks, Tamara Widenhouse, Frederick E. Shelton, IV, Jason L. Harris, Jeffrey S. Swayze, Foster B. Stulen, Prasanna Malaviya, Gregory W. Johnson, Paul Guerra
Publication number: 20150197529
Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.
Type:
Application
Filed:
January 9, 2015
Publication date:
July 16, 2015
Applicant:
Genentech, Inc.
Inventors:
Benjamin Fauber, Alberto Gobbi, Olivier Rene, Monique Bodil van Niel, Emanuela Gancia, Simon Gaines, Tammy Laddywahetty, David Vesey, Stuart Ward, Paul Winship