Patents by Inventor Paul Torrence

Paul Torrence has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RNase L activator-antisense complexes
    Publication number: 20030203356
    Abstract: The present invention relates to methods of targeting RNA and is particularly useful for inhibiting infection by RNA viruses with complexes of an activator of RNase L and an oligonucleotide that is capable of binding to the genome, antigenome or mRNAs of a target RNA (e.g. a negative strand RNA virus) to specifically cleave the genomic or antigenomic RNA strand of the target RNA (e.g. the virus). The invention in one embodiment relates to a covalently linked complex of an oligonucleotide that is capable of binding to the genomic or antigenomic template RNA strand of a negative strand RNA virus and/or binding to an mRNA of a viral protein (an “antisense oligonucleotide”) coupled to an activator of RNase L. In a preferred embodiment of the present invention, the oligonucleotide component of the complex is complementary to a region of the viral genomic RNA strand characterized by repeated or consensus sequences.
    Type: Application
    Filed: January 22, 2003
    Publication date: October 30, 2003
    Applicant: The Cleveland Clinic Foundation
    Inventors: Robert Silverman, Hagen Cramer, Douglas Leaman, Paul Torrence
  • Method of cleaving specific strands of RNA and medical treatments thereby
    Patent number: 5677289
    Abstract: A method of using a chimeric molecule made up of an antisense oligonucleotide attached to a 2',5'-oligoadenylate molecule to specifically cleave a sense strand of RNA, wherein the antisense oligonucleotide of the chimeric molecule is hybridized to the sense strand of RNA in the presence of 2',5'-dependent RNase.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: October 14, 1997
    Assignees: The Cleveland Clinic Foundation, The United States of America
    Inventors: Paul Torrence, Robert Silverman, Ratan Maitra, Krystyna Lesiak
  • Method of cleaving specific strands of RNA
    Patent number: 5583032
    Abstract: A method of using a chimeric molecule made up of an antisense oligonucleotide attached to a 2',5'-oligoadenylate molecule to specifically cleave a sense strand of RNA, wherein the antisense oligonucleotide of the chimeric molecule is hybridized to the sense strand of RNA in the presence of 2',5'-dependent RNase.
    Type: Grant
    Filed: September 17, 1993
    Date of Patent: December 10, 1996
    Assignee: The Cleveland Clinic Foundation and National Institutes of Health
    Inventors: Paul Torrence, Robert Silverman, Ratan Maitra, Krystyna Lesiak