Patents by Inventor Paul Toumbas

Paul Toumbas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8735056
    Abstract: A new device capable of measuring the number of particles present in a colloidal suspension is disclosed, which includes a forward scatter detector, an extinction detector, a laser beam, a cylindrical lens with which to create a plane of light through which particles can pass, and the various pumps and tubing needed to pass the colloidal suspension through the plane of light. The device is particularly designed for measuring particles which have different refractive indices, and which are in the size range of between about 0.7 to 2 microns. The device can determine the presence or absence of biological particles of interest in a given sample, by incubating a sample with a given ratio of active particles and marker particles, and determining whether the ratio of active particles and marker particles has changed. Additional binding and/or non-binding particles can also be present, and kits including the particles are also disclosed.
    Type: Grant
    Filed: May 20, 2010
    Date of Patent: May 27, 2014
    Assignee: Invitrox, Inc.
    Inventors: Paul Toumbas, Don Gabriel
  • Publication number: 20120135405
    Abstract: A new device capable of measuring the number of particles present in a colloidal suspension is disclosed, which includes a forward scatter detector, an extinction detector, a laser beam, a cylindrical lens with which to create a plane of light through which particles can pass, and the various pumps and tubing needed to pass the colloidal suspension through the plane of light. The device is particularly designed for measuring particles which have different refractive indices, and which are in the size range of between about 0.7 to 2 microns. The device can determine the presence or absence of biological particles of interest in a given sample, by incubating a sample with a given ratio of active particles and marker particles, and determining whether the ratio of active particles and marker particles has changed. Additional binding and/or non-binding particles can also be present, and kits including the particles are also disclosed.
    Type: Application
    Filed: May 20, 2010
    Publication date: May 31, 2012
    Applicant: Invitrox, Inc
    Inventors: Paul Toumbas, Don Gabriel
  • Patent number: 7496463
    Abstract: A single-particle optical sensor, which has high sensitivity and responds to relatively concentrated suspensions, uses a relatively narrow light beam to illuminate an optical sensing zone nonuniformly. The zone is smaller than the flow channel so that the sensor responds to only a fraction of the total number of particles flowing through the channel, detecting a statistically significant number of particles of any relevant diameter. Because different particle trajectories flow through different parts of the zone illuminated at different intensities, it is necessary to deconvolute the result. Two methods of deconvolution are used: modified matrix inversion or successive subtraction. Both methods use a few basis vectors measured empirically or computed from a theoretical model, and the remaining basis vectors are derived from these few. The sensor is compensated for turbidity. Several embodiments are disclosed employing light-extinction or light-scattering detection, or both.
    Type: Grant
    Filed: September 12, 2006
    Date of Patent: February 24, 2009
    Assignee: Agilent Technologies, Inc.
    Inventors: David F. Nicoli, Paul Toumbas
  • Publication number: 20070010974
    Abstract: A single-particle optical sensor, which has high sensitivity and responds to relatively concentrated suspensions, uses a relatively narrow light beam to illuminate an optical sensing zone nonuniformly. The zone is smaller than the flow channel so that the sensor responds to only a fraction of the total number of particles flowing through the channel, detecting a statistically significant number of particles of any relevant diameter. Because different particle trajectories flow through different parts of the zone illuminated at different intensities, it is necessary to deconvolute the result. Two methods of deconvolution are used: modified matrix inversion or successive subtraction. Both methods use a few basis vectors measured empirically or computed from a theoretical model, and the remaining basis vectors are derived from these few. The sensor is compensated for turbidity. Several embodiments are disclosed employing light-extinction or light-scattering detection, or both.
    Type: Application
    Filed: September 12, 2006
    Publication date: January 11, 2007
    Inventors: David Nicoli, Paul Toumbas
  • Patent number: 7127356
    Abstract: A single-particle optical sensor, which has high sensitivity and responds to relatively concentrated suspensions, uses a relatively narrow light beam to illuminate an optical sensing zone nonuniformly. The zone is smaller than the flow channel so that the sensor responds to only a fraction of the total number of particles flowing through the channel, detecting a statistically significant number of particles of any relevant diameter. Because different particle trajectories flow through different parts of the zone illuminated at different intensities, it is necessary to deconvolute the result. Two methods of deconvolution are used: modified matrix inversion or successive subtraction. Both methods use a few basis vectors measured empirically or computed from a theoretical model, and the remaining basis vectors are derived from these few. The sensor is compensated for turbidity. Several embodiments are disclosed employing light-extinction or light-scattering detection, or both.
    Type: Grant
    Filed: May 18, 2004
    Date of Patent: October 24, 2006
    Assignee: Particle Sizing Systems, Inc.
    Inventors: David F. Nicoli, Paul Toumbas
  • Publication number: 20050021244
    Abstract: A single-particle optical sensor, which has high sensitivity and responds to relatively concentrated suspensions, uses a relatively narrow light beam to illuminate an optical sensing zone nonuniformly. The zone is smaller than the flow channel so that the sensor responds to only a fraction of the total number of particles flowing through the channel, detecting a statistically significant number of particles of any relevant diameter. Because different particle trajectories flow through different parts of the zone illuminated at different intensities, it is necessary to deconvolute the result. Two methods of deconvolution are used: modified matrix inversion or successive subtraction. Both methods use a few basis vectors measured empirically or computed from a theoretical model, and the remaining basis vectors are derived from these few. The sensor is compensated for turbidity. Several embodiments are disclosed employing light-extinction or light-scattering detection, or both.
    Type: Application
    Filed: May 18, 2004
    Publication date: January 27, 2005
    Applicant: Particle Sizing Systems, Inc.
    Inventors: David Nicoli, Paul Toumbas
  • Patent number: 6794671
    Abstract: A single-particle optical sensor, which has high sensitivity and responds to relatively concentrated suspensions, uses a relatively narrow light beam to illuminate an optical sensing zone nonuniformly. The zone is smaller than the flow channel so that the sensor responds to only a fraction of the total number of particles flowing through the channel, detecting a statistically significant number of particles of any relevant diameter. Because different particle trajectories flow through different parts of the zone illuminated at different intensities, it is necessary to deconvolute the result. Two methods of deconvolution are used: modified matrix inversion or successive subtraction. Both methods use a few basis vectors measured empirically or computed from a theoretical model, and the remaining basis vectors are derived from these few. The sensor is compensated for turbidity. Several embodiments are disclosed employing light-extinction or light-scattering detection, or both.
    Type: Grant
    Filed: July 17, 2002
    Date of Patent: September 21, 2004
    Assignee: Particle Sizing Systems, Inc.
    Inventors: David F. Nicoli, Paul Toumbas
  • Publication number: 20040011975
    Abstract: A single-particle optical sensor, which has high sensitivity and responds to relatively concentrated suspensions, uses a relatively narrow light beam to illuminate an optical sensing zone nonuniformly. The zone is smaller than the flow channel so that the sensor responds to only a fraction of the total number of particles flowing through the channel, detecting a statistically significant number of particles of any relevant diameter. Because different particle trajectories flow through different parts of the zone illuminated at different intensities, it is necessary to deconvolute the result. Two methods of deconvolution are used: modified matrix inversion or successive subtraction. Both methods use a few basis vectors measured empirically or computed from a theoretical model, and the remaining basis vectors are derived from these few. The sensor is compensated for turbidity. Several embodiments are disclosed employing light-extinction or light-scattering detection, or both.
    Type: Application
    Filed: July 17, 2002
    Publication date: January 22, 2004
    Inventors: David F. Nicoli, Paul Toumbas