Abstract: A request is received to book a flight on a private aircraft. A disruption cost associated with adding the flight to a previously optimized schedule of previously booked flights is determined. A price to be quoted to book the requested flight is computed based at least in part on the disruption cost.

Abstract: A request is received to book a flight on a private aircraft. A disruption cost associated with adding the flight to a previously optimized schedule of previously booked flights is determined. A price to be quoted to book the requested flight is computed based at least in part on the disruption cost.

Abstract: The invention relates to the use of inhibitors of the expressed proteins of the murine genes and/or their human homologues listed in Table 1 for the preparation of a therapeutical composition for the treatment of cancer, in particular for the treatment of solid tumors of lung, colon, breast, prostate, ovarian, pancreas and leukemia and the use of the genes listed in Table 1 for the diagnosis of cancer. The invention also relates to the therapeutical compositions comprising the inhibitors and to methods for development of the inhibitor compounds.

Abstract: The present invention comprises a method method to identify tumor suppressor genes by detecting genes in a mouse retroviral insertion mutagenesis model which expression is inhibited by methylation of the viral insertion or the VIS-flanking gene. This is preferably accomplished by first randomly cutting the mouse genomic DNA, immunoprecipitating the methylated DNA and amplifying the VIS-flanking DNA by inverse PCR, optionally followed by cloning and sequencing of the amplicons. Next to the already known tumor suppressor genes Smad1 and Mad1-like, several putative tumor suppressor genes have been found. The tumor suppressing properties of these genes, as indicated in Table 3 also form part of the present invention. Further use of these genes and/or its substrates or downstream products, for diagnosis and therapy of cancer, preferably AML is envisaged.