Abstract: The present invention includes molecules, composition, and methods for making and using a molecule having the formula: wherein R? is selected from H, methoxy, methoxymethyl, glycosyl, phosphoryl, alkylamine, polyethylene glycol (PEG), or deuterated; X is selected from OH, methoxy, methoxymethyl, O-methoxymethyl, carbonyl, or alcohol; Y is O; and R? is selected from H, butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl, or dodecyl, that are saturated or unsaturated, PEG, or triphenylphosphate groups; optionally one or both MeO groups are deuterated; and N is N-oxide or N-alkyl.

Abstract: Provided herein are compounds and methods for modulating the mitochondrial respiratory complex II (CII) and vascular endothelial growth factor (VEGF) pathways. More particularly, provided are inhibitors of the mitochondrial respiratory complex II (CII) and vascular endothelial growth factor (VEGF) pathways and the uses of such inhibitors in regulating diseases and disorders, e.g., to treat cancer.

Abstract: The present invention includes compositions and methods for treating a subject afflicted with a neurodegenerative disorder or disease by determining that the subject is in need of treatment for the neurodegenerative disorder or disease; and administering to the subject an amount of an effective amount of a compound comprising a flupirtine derivative as disclosed herein.

Abstract: The present invention includes a composition and method of allosterically potentiating the activity of neurolysin comprising contacting the neurolysin with an amount of a histidine-containing dipeptide that is an allosteric that increases the activity of neurolysin.

Abstract: The present invention includes molecules, composition, and methods for making and using a molecule having the formula (I), wherein R? is selected from H, methoxy, or methoxymethyl; X is selected from H, OH, methoxy, or methoxymethyl or O—O methoxymethyl; Y is O; and R? is selected from H, OH, 2-furan, ethyl, propyl, pentyl, hexyl, heptyl, octyl, nonly, decyl, or dodecyl, that are saturated or unsaturated.

Abstract: The present invention includes compositions and methods for treating a subject afflicted with a neurodegenerative disorder or disease by determining that the subject is in need of treatment for the neurodegenerative disorder or disease; and administering to the subject an amount of an effective amount of a compound comprising a flupirtine derivative as disclosed herein.