Abstract: Provided herein are bispecific antibodies having modifications that enable greater developability and manufacturability. In certain instances, such bispecific antibodies comprise common light chain bispecific antibodies that bind CD38 and CD19, having reduced isoelectric focusing, improved hydrophobic interaction chromatography retention, and effective targeting of cells expressing CD19 and CD38. Also provided are methods of reducing an experimental isoelectric point of bispecific antibodies that bind CD19 and CD38.

Abstract: Provided herein are common light chain bispecific antibodies that bind CD38 and CD19. The common light chain bispecific antibodies comprise an anti-CD38 heavy chain variable region and anti CD19 heavy chain variable region that each have a negatively-charged amino acid at a terminal heavy chain variable region position. The common light chain bispecific antibodies comprise further comprise an anti-CD38 heavy chain constant region and anti-CD19 heavy chain constant region that each lack a C-terminal lysine residue. Further provided are nucleic acids encoding such common light chain bispecific antibodies and host cells comprising the nucleic acids. Also provided are methods of making such common light chain bispecific antibodies.

Abstract: Described herein is a method of treating a cancer or tumor associated with CD19 positive, CD38 positive, CD20 negative immunosuppressive B cells in an individual comprising administering to the individual a bispecific antibody that binds CD19 and CD38, thereby treating the cancer or tumor associated with CD19 positive, CD38 positive, CD20 negative immunosuppressive B cells.

Abstract: Described herein is a composite binding molecule, wherein the composite binding molecule comprises a (i) CD38 antigen binding component that binds CD38, (ii) a CD19 antigen binding component that binds CD19, and (iii) a variant Fc region comprising one or more mutations relative to a wildtype Fc region, wherein the variant Fc region exhibits reduced effector function compared to the wildtype Fc region. Also described are methods of using the composite binding molecule in a method of treating cancer.

Abstract: Described herein are multispecific binding antibodies with reduced isoelectric focusing point.

Abstract: Provided are anti-CD19 and anti-CD38 common light chain bispecific antibodies. The anti-CD-19 and anti-CD38 bispecific antibodies described herein are useful in methods for treating a cancer or a tumor.

Abstract: Provided are anti-CD19 and anti-CD38 common light chain bispecific antibodies. The anti-CD-19 and anti-CD38 bispecific antibodies described herein are useful in methods for treating a cancer or a tumor.

Abstract: Provided are anti-CD19 and anti-CD38 common light chain bispecific antibodies. The anti-CD-19 and anti-CD38 bispecific antibodies described herein are useful in methods for treating a cancer or a tumor.

Abstract: Provided are anti-CD19 and anti-CD38 common light chain bispecific antibodies. The anti-CD-19 and anti-CD38 bispecific antibodies described herein are useful in methods for treating a cancer or a tumor.

Abstract: Provided are anti-CD19 and anti-CD38 common light chain bispecific antibodies. The anti-CD19 and anti-CD38 bispecific antibodies described herein are useful in methods for treating a cancer or a tumor.

Abstract: Targeting immunosuppressive B-cell populations with bispecific or multivalent targeting molecules presents a potential pathway for therapeutic intervention that effectively modulates the anti-tumor immune response to improve therapeutic outcomes. Accordingly, there remains a need for engineered antibody-based therapeutics that can effectively and selectively target immunosuppressive B-cell populations for the treatment of cancer. Provided are composite binding molecules that target immunosuppressive B cells.

Abstract: This invention relates to the use of in-vivo hyperspectral imaging to monitor angiogenesis. Specifically, the invention provides systems and methods of obtaining hyperspectral images of a field of view comprising an area sought to be monitored.