Patents by Inventor Paul V. Phibbs

Paul V. Phibbs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Catabolite repression control (Crc) gene and Pseudomonas virulence
    Patent number: 6824979
    Abstract: The present invention relates to a method of screening for compounds that inhibit the virulence of Pseudomonas bacteria and comprises the steps of: providing a culture medium comprising Pseudomonas bacteria, administering a test compound to said bacteria, and then detecting the presence or absence of inhibition of the catabolite repression control (Crc) protein in the bacteria. The inhibition of the Crc protein indicates that the compound has antivirulence activity against Pseudomonas bacteria. Antisense oligonucleotides that inhibit expression of the Crc protein in a Pseudomonas bacteria and is nuclease resistant are also disclosed. Antivirulence compounds and the uses thereof in treating Pseudomonas infections are also disclosed.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: November 30, 2004
    Assignee: East Carolina University
    Inventors: Paul V. Phibbs, David N. Collier, Paul W. Hager
  • Catabolite repression control (Crc) gene and pseudomonas virulence
    Publication number: 20020102628
    Abstract: A method of screening for compounds that inhibit the virulence of Pseudomonas bacteria comprises the steps of: providing a culture medium comprising Pseudomonas bacteria; administering a test compound to said bacteria; and then detecting the presence or absence of inhibition of the catabolite repression control (Crc) protein in said bacteria, the inhibition of the Crc protein indicating said compound has antivirulence activity against Pseudomonas bacteria. Antivirulence compounds and the use thereof in treating Pseudomonas infections are also disclosed.
    Type: Application
    Filed: December 21, 2000
    Publication date: August 1, 2002
    Inventors: Paul V. Phibbs, David N. Collier, Paul W. Hager