Abstract: A medical device include a polyurethane layer and a hydro-specific layer that is covalently bonded to the polyurethane layer. The polyurethane layer may include a plurality of monomer residues, at least some of which include pendent alkene groups. The hydro-specific layer may be a hydrophilic layer or a hydrophobic layer depending on the specific molecules used to form the hydro-specific layer. As an example, the hydro-specific layer may be covalently bonded to the polyurethane layer via a thiol-ene or alkene hydrothiolation reaction between the plurality of pendent alkene groups and a plurality of thiol-terminated hydro-specific molecules forming the hydro-specific layer.

Abstract: A chemotherapy agent comprising a chemotherapy group and a ligand secured to the chemotherapy group is disclosed, the ligand comprising a reactive group capable of bonding to a capture substrate. A method of removing chemotherapy agents from a patient is disclosed, the method comprising providing a chemotherapy agent containing a reactive group; providing a capture substrate in contact with a patient's bloodstream; administering the chemotherapy agent to the patient; and sequestering the chemotherapy agent on the capture substrate. A system for removing chemotherapy agents is also disclosed.

Abstract: Embodiments herein relate to medical devices and methods for monitoring and/or treatment including the use of synthetic polymers exhibiting specific binding for compounds such as disease state markers or toxic substances. In an embodiment, a method of testing a patient for a disease state is included, the method can include withdrawing a fluid sample from the patient and contacting the fluid sample with an extracorporeal monitoring device. The extracorporeal monitoring device can include a microporous membrane. The microporous membrane can include a synthetic polymer, wherein the synthetic polymer exhibits binding specificity with a disease state marker. The method can further include evaluating the extracorporeal monitoring device for the presence of the disease state marker. Other embodiments are included herein.

Abstract: A lubricious coating for use on an implantable medical device includes a heterochelic component, a homotelechelic polymer and biocompatible initiator. Methods of forming such lubricious coatings are also provided.

Abstract: A lubricious coating for use on an implantable medical device includes a heterochelic component, a homotelechelic polymer and biocompatible initiator. Methods of forming such lubricious coatings are also provided.

Abstract: In some aspects of the present invention, coatings are provided which provide lubricity as well as additional functionality. Further aspects of the invention pertain to medical devices having such coatings and methods of forming such coatings.

Abstract: A waterborne acrylate-functionalized alkyd coating composition is disclosed, which includes an acrylate-functionalized alkyd resin, at least one drier, and water. The acrylate-functionalized alkyd resin comprises the reaction product of (i) a hydroxy functional alkyd resin, (ii) an acid anhydride, and (iii) a glycidyl acrylate. Methods of preparing waterborne acrylate-functionalized alkyd coating compositions are also disclosed.

Abstract: A solvent-borne acrylate-functionalized alkyd coating composition is disclosed which includes an acrylate-functionalized alkyd, at least one drier, and an organic solvent. Also disclosed is a waterborne acrylate-functionalized alkyd coating composition including an acrylate-functionalized alkyd resin, at least one drier, and water. The acrylate-functionalized alkyd resin comprises the reaction product of (i) an alkyd resin having an acid number from greater than 0 to about 10 mg KOH/g, and (ii) a glycidyl acrylate. Also disclosed are methods of preparing acrylate-functionalized alkyd coating compositions, and coating compositions made by such methods.

Abstract: Acetoacetate-functional alkyd resins are disclosed, as are compositions including such resins in combination with at least one drier and an organic solvent. The acetoacetate-functional alkyd resin described is the reaction product of an alkyd resin with an alkyl acetoacetate. Also disclosed are methods of preparing such compositions, and uses for such compositions.

Abstract: A waterborne acetoacetate-functionalized alkyd coating composition is disclosed which includes an acetoacetate-functionalized alkyd resin, at least one drier, and water. The acetoacetate-functionalized alkyd resin is the reaction product of (i) an alkyd resin, and (ii) an alkyl acetoacetate. Also disclosed is a method of preparing a waterborne acetoacetate-functionalized alkyd coating composition which includes the step of contacting an acetoacetate-functionalized alkyd resin with at least one drier in the presence of water.

Abstract: A solvent-borne acrylate-functionalized alkyd coating composition is disclosed which includes an acrylate-functionalized alkyd, at least one drier, and an organic solvent. Also disclosed is a waterborne acrylate-functionalized alkyd coating composition including an acrylate-functionalized alkyd resin, at least one drier, and water. The acrylate-functionalized alkyd resin comprises the reaction product of (i) an alkyd resin having an acid number from greater than 0 to about 10 mg KOH/g, and (ii) a glycidyl acrylate. Also disclosed are methods of preparing acrylate-functionalized alkyd coating compositions, and coating compositions made by such methods.

Abstract: Acetoacetate-functional alkyd resins are disclosed, as are compositions including such resins in combination with at least one drier and an organic solvent. The acetoacetate-functional alkyd resin described is the reaction product of an alkyd resin with an alkyl acetoacetate. Also disclosed are methods of preparing such compositions, and uses for such compositions.

Abstract: A waterborne acrylate-functionalized alkyd coating composition is disclosed, which includes an acrylate-functionalized alkyd resin, at least one drier, and water. The acrylate-functionalized alkyd resin comprises the reaction product of (i) a hydroxy functional alkyd resin, (ii) an acid anhydride, and (iii) a glycidyl acrylate. Methods of preparing waterborne acrylate-functionalized alkyd coating compositions are also disclosed.

Abstract: A waterborne acetoacetate-functionalized alkyd coating composition is disclosed which includes an acetoacetate-functionalized alkyd resin, at least one drier, and water. The acetoacetate-functionalized alkyd resin is the reaction product of (i) an alkyd resin, and (ii) an alkyl acetoacetate. Also disclosed is a method of preparing a waterborne acetoacetate-functionalized alkyd coating composition which includes the step of contacting an acetoacetate-functionalized alkyd resin with at least one drier in the presence of water.