Abstract: Methods and systems are described to identify potential failures caused by metastability arising from signal propagation between asynchronous clock domains in integrated circuits with multiple operating modes, each mode allowing selected clocks to propagate. Typical integrated circuits have numerous operating modes, and hence numerous possible clock combinations, each combination causing different asynchronous clock-domain crossings, and hence different potential failures. Since verification for even one clock combination is time-consuming, explicitly enumerating and verifying all possible clock combinations is unviable. In practice very few clock combinations are verified, possibly missing failures.