Patents by Inventor Paul W. Barone

Paul W. Barone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10215752
    Abstract: A composition can include a nanostructure, and a linker associated with the nanostructure, wherein the linker is configured to interact with a capture protein. The nanostructure can include a single-walled carbon nanotube. A plurality of the compositions can be configured in an array.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: February 26, 2019
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Michael S. Strano, Jin-Ho Ahn, Jong-Ho Kim, Paul W. Barone, Nigel F. Reuel
  • Patent number: 9980668
    Abstract: A composition for sensing an analyte can include a photoluminescent nanostructure complexed to a sensing polymer, where the sensing polymer includes an organic polymer non-covalently bound to the photoluminescent nanostructure and an analyte-binding protein covalently bound to the organic polymer, and where the analyte-binding protein is capable of selectively binding the analyte, and the analyte-binding protein undergoes a substantial conformational change when binding the analyte. Separately, a composition for sensing an analyte, can include a complex, where the complex includes a photoluminescent nanostructure in an aqueous surfactant dispersion and a boronic acid capable of selectively reacting with an analyte. The compositions can be used in devices and methods for sensing an analyte.
    Type: Grant
    Filed: July 31, 2012
    Date of Patent: May 29, 2018
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Michael S. Strano, Paul W. Barone, Jin-Ho Ahn, Kyungsuk Yum, Thomas P. McNicholas
  • Patent number: 8377700
    Abstract: Systems and methods related to compositions including hydrogels and photoluminescent nanostructures are described. The compositions can undergo a change in a physical, chemical, dielectric, or other property upon exposure to an altering stimulus. Changes in one or more properties of the hydrogel may impart a change in the photoluminescence of the nanostructures embedded in the hydrogel.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: February 19, 2013
    Assignee: Massachusetts Institute of Technology
    Inventors: Michael S. Strano, Paul W. Barone, Jin-Ho Ahn, Ardemis Anoush Boghossian, Rene Ortiz-Garcia, Hyeonseok Yoon, Jingqing Zhang
  • Publication number: 20130035567
    Abstract: A composition for sensing an analyte can include a photoluminescent nanostructure complexed to a sensing polymer, where the sensing polymer includes an organic polymer non-covalently bound to the photoluminescent nanostructure and an analyte-binding protein covalently bound to the organic polymer, and where the analyte-binding protein is capable of selectively binding the analyte, and the analyte-binding protein undergoes a substantial conformational change when binding the analyte. Separately, a composition for sensing an analyte, can include a complex, where the complex includes a photoluminescent nanostructure in an aqueous surfactant dispersion and a boronic acid capable of selectively reacting with an analyte. The compositions can be used in devices and methods for sensing an analyte.
    Type: Application
    Filed: July 31, 2012
    Publication date: February 7, 2013
    Inventors: Michael S. Strano, Paul W. Barone, Jin-Ho Ahn, Kyungsuk Yum, Thomas P. McNicholas
  • Publication number: 20120178640
    Abstract: A composition can include a nanostructure, and a linker associated with the nanostructure, wherein the linker is configured to interact with a capture protein. The nanostructure can include a single-walled carbon nanotube. A plurality of the compositions can be configured in an array.
    Type: Application
    Filed: August 31, 2011
    Publication date: July 12, 2012
    Applicant: Massachusetts Institute of Technology
    Inventors: Michael S. Strano, Jin-Ho Ahn, Jong-Ho Kim, Paul W. Barone, Nigel F. Reuel
  • Publication number: 20110042618
    Abstract: Systems and methods related to handling and/or isolating nanotubes and other nanostructures are generally described. In some embodiments, a polymer can be exposed to a collection of agglomerated nanostructures to produce individuated nanostructures. The polymer can comprise one or more pendant groups capable of participating in a pi-pi interaction with at least a portion of the agglomerated nanostructures to produce individuated nanostructures. Individuated nanostructures can be isolated from nanostructures that remain agglomerated. In some cases, individuated nanostructures can be freeze dried to provide, for example, a plurality of nanostructures in solid form. The systems and methods described herein may be so effective in maintaining separation between individuated nanostructures that pluralities of dried nanostructures can be re-suspended in a fluid after they are dried, in some cases with relatively low forces applied during re-suspension.
    Type: Application
    Filed: August 21, 2009
    Publication date: February 24, 2011
    Applicant: Massachusetts Institute of Techonology
    Inventors: Michael S. Strano, Woo-Jae Kim, Paul W. Barone
  • Publication number: 20100279421
    Abstract: Systems and methods related to compositions including hydrogels and photoluminescent nanostructures are described. The compositions can undergo a change in a physical, chemical, dielectric, or other property upon exposure to an altering stimulus. Changes in one or more properties of the hydrogel may impart a change in the photoluminescence of the nanostructures embedded in the hydrogel.
    Type: Application
    Filed: February 26, 2010
    Publication date: November 4, 2010
    Applicant: Massachusetts Institute of Technology
    Inventors: Michael S. Strano, Paul W. Barone