Patents by Inventor Paul W. Bohn
Paul W. Bohn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220011304Abstract: Described is a biosensor for detection of analytes and methods of using the same for detecting bacterial infection in a subject. The biosensor comprises an array of gold nanoparticles, biotinylated polyethylene glycol thiol, polyethylene glycol thiol, at least one neutravidin molecule, and at least one affinity reagent immobilized on a surface of the at least one neutravidin molecule. The affinity reagent may be an aptamer or a siderophore. The biosensors demonstrate extraordinary selectively and sensitivity for rapid detection of whole-cell bacteria.Type: ApplicationFiled: December 20, 2018Publication date: January 13, 2022Inventors: Jiayun Hu, Paul W. Bohn, Marvin J. Miller, Manuka Ghosh
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Patent number: 10908094Abstract: The described BPE-enabled device includes two separated chambers which perform detection and reporting independently. Analytical reaction of a target molecule in the analytical cell is coupled to and monitored by an electrochromic reaction in the reporting cell. The color change in the reporting cell can be determined spectrophotometrically by RGB analysis of a CCD image acquired via smartphone. This detection method provides a linear response and a low limit of detection due to the redox cycling behavior in both chambers. The BPE based electrochromic detector can be modified for sensing of multiple analytes by integrating three or more sets of detection chemistries into one single device. Multiple analytes with different concentrations can be detected within this device simultaneously.Type: GrantFiled: August 11, 2017Date of Patent: February 2, 2021Assignee: University of Notre Dame du LacInventors: Paul W. Bohn, Wei Xu, Kaiyu Fu, Chaoxiong Ma
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Publication number: 20190178807Abstract: The described BPE-enabled device includes two separated chambers which perform detection and reporting independently. Analytical reaction of a target molecule in the analytical cell is coupled to and monitored by an electrochromic reaction in the reporting cell. The color change in the reporting cell can be determined spectrophotometrically by RGB analysis of a CCD image acquired via smartphone. This detection method provides a linear response and a low limit of detection due to the redox cycling behavior in both chambers. The BPE based electrochromic detector can be modified for sensing of multiple analytes by integrating three or more sets of detection chemistries into one single device. Multiple analytes with different concentrations can be detected within this device simultaneously.Type: ApplicationFiled: August 11, 2017Publication date: June 13, 2019Applicant: University of Notre Dame du LacInventors: Paul W. BOHN, Wei XU, Kaiyu FU, Chaoxiong MA
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Publication number: 20150323495Abstract: The invention provides devices and methods for the detection of hydrophobic biomarkers using 3D microchip capillary electrophoresis having a non-aqueous solvent system. Hydrophobic biomarkers can be placed in a microcapillary microchannel and electrokinetically injected into a second microcapillary microchannel through a nanocapillary array membrane. The hydrophobic biomarkers can then be separated and analyzed via mass spectrometry. Certain hydrophobic biomarkers can indicate a particular disease state.Type: ApplicationFiled: December 20, 2013Publication date: November 12, 2015Applicant: UNIVERSITY OF NOTRE DAME DU LACInventors: Larry R. Gibson, II, Paul W. Bohn
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Patent number: 7445027Abstract: A method of bonding layers to form a structure, comprises curing a first adhesive while squeezing a first layer and a multilayer structure together between a first backing and a second backing. The multilayer structure comprises a substrate and a second layer, and the first adhesive is between and in contact with the first layer and the second layer. Furthermore, the first layer and the second layer each have a thickness of at most 100 ?m, and at least one of the first backing and the second backing comprises a first elastic polymer.Type: GrantFiled: March 14, 2006Date of Patent: November 4, 2008Assignee: The Board of Trustees of the University of IllinoisInventors: Bruce R. Flachsbart, Mark A. Shannon, Paul W. Bohn, Jonathan V Sweedler
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Patent number: 7220345Abstract: A fluid circuit includes a membrane having a first side, a second side opposite the first side, and a pore extending from the first side to the second side. The circuit also includes a first channel containing fluid extending along the first side of the membrane and a second channel containing fluid extending along the second side of the membrane and crossing the first channel. The circuit also includes an electrical source in electrical communication with at least one of the first fluid and second fluid for selectively developing an electrical potential between fluid in the first channel and fluid in the second channel. This causes at least one component of fluid to pass through the pore in the membrane from one of the first channel and the second channel to the other of the first channel and the second channel.Type: GrantFiled: October 18, 2002Date of Patent: May 22, 2007Assignee: The Board of Trustees of the University of IllinoisInventors: Paul W. Bohn, Jonathan V. Sweedler, Mark A. Shannon, Tzu-chi Kuo
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Patent number: 6790785Abstract: A thin discontinuous layer of metal such as Au, Pt, or Au/Pd is deposited on a silicon surface. The surface is then etched in a solution including HF and an oxidant for a brief period, as little as a couple seconds to one hour. A preferred oxidant is H2O2. Morphology and light emitting properties of porous silicon can be selectively controlled as a function of the type of metal deposited, Si doping type, silicon doping level, and/or etch time. Electrical assistance is unnecessary during the chemical etching of the invention, which may be conducted in the presence or absence of illumination.Type: GrantFiled: September 15, 2000Date of Patent: September 14, 2004Assignee: The Board of Trustees of the University of IllinoisInventors: Xiuling Li, Paul W. Bohn, Jonathan V. Sweedler
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Patent number: 6762134Abstract: A thin discontinuous layer of metal such as Au, Pt, or Au/Pd is deposited on a Group III-V material surface. The surface is then etched in a solution including HF and an oxidant for a preferably brief period, as little as a couple seconds to one hour. A preferred oxidant is H2O2. Morphology and light emitting properties of porous Group III-V material can be selectively controlled as a function of the type of metal deposited, doping type, doping level, metal thickness, whether emission is collected on or off the metal coated areas and/or etch time. Electrical assistance is unnecessary during the chemical etching of the invention, which may be conducted in the presence or absence of illumination.Type: GrantFiled: November 20, 2001Date of Patent: July 13, 2004Assignee: The Board of Trustees of the University of IllinoisInventors: Paul W. Bohn, Xiuling Li, Jonathan V. Sweedler, Ilesanmi Adesida
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Publication number: 20030136679Abstract: A fluid circuit includes a membrane having a first side, a second side opposite the first side, and a pore extending from the first side to the second side. The circuit also includes a first channel containing fluid extending along the first side of the membrane and a second channel containing fluid extending along the second side of the membrane and crossing the first channel. The circuit also includes an electrical source in electrical communication with at least one of the first fluid and second fluid for selectively developing an electrical potential between fluid in the first channel and fluid in the second channel. This causes at least one component of fluid to pass through the pore in the membrane from one of the first channel and the second channel to the other of the first channel and the second channel.Type: ApplicationFiled: October 18, 2002Publication date: July 24, 2003Applicant: The Board of Trustees of the University of IllinoisInventors: Paul W. Bohn, Jonathan V. Sweedler, Mark A. Shannon, Tzu-chi Kuo
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Publication number: 20020074314Abstract: A thin discontinuous layer of metal such as Au, Pt, or Au/Pd is deposited on a Group III-V material surface. The surface is then etched in a solution including HF and an oxidant for a preferably brief period, as little as a couple seconds to one hour. A preferred oxidant is H2O2. Morphology and light emitting properties of porous Group III-V material can be selectively controlled as a function of the type of metal deposited, doping type, doping level, metal thickness, whether emission is collected on or off the metal coated areas and/or etch time. Electrical assistance is unnecessary during the chemical etching of the invention, which may be conducted in the presence or absence of illumination.Type: ApplicationFiled: November 20, 2001Publication date: June 20, 2002Applicant: The Board of Trustees of the University of Illinois.Inventors: Paul W. Bohn, Xiuling Li, Jonathan V. Sweedler, Ilesanmi Adesida
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Patent number: 5556528Abstract: Devices are useful to capture or dispense target molecules and include an electric field-responsive valve unit. The valve unit includes an active control structure having at least one monomolecular layer and being up to about 10 nm thick. The active control structure is formed by a majority of molecular species with a dipolar moment greater than about 5 Debye, and operable in response to an electric field at a threshold value. A particularly preferred embodiment has the active control structure carried on a microporous membrane with pores in the nanometer range. Applications for inventive embodiments include drug delivery and target molecule capture during electrophoresis separations.Type: GrantFiled: May 10, 1994Date of Patent: September 17, 1996Assignee: Biotechnology Research & Development CorporationInventors: Paul W. Bohn, Wenyuan Lu
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Patent number: 5466589Abstract: The present invention is directed to coated substrates having a coating of biological macromolecules, preferably proteins, which are capable of being immobilized on a substrate surface and have a marker. These proteins usually are mutant proteins obtained by mutagenesis of the gene encoding a random positioning protein. When a mutant protein molecule is immobilized on the substrate, the marker of the mutant protein molecule is in a select spatial relationship with both the substrate and the markers of adjacent protein molecules. A substrate coated with an oriented layer of the mutant proteins exhibits improved or different properties when compared to a substrate having a randomly positioned layer of proteins thereon.Type: GrantFiled: September 11, 1992Date of Patent: November 14, 1995Assignee: Biotechnology Research & Development CorporationInventors: Jill M. Olinger, Stephen G. Sligar, Mark A. McLean, Paul W. Bohn, Patrick Stayton