Patents by Inventor Paul W. Diaz

Paul W. Diaz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel cell signaling polypeptides and nucleic acids
    Publication number: 20040072772
    Abstract: The present invention relates to an isolated SRK polypeptide, biologically-active polypeptide fragments thereof, and nucleic acids which code for it. This polypeptide has various activities in regulating cell signaling and signal transduction pathways, including, e.g., a protein kinase activity; an autophosphorylating activity; a cell survival promoting activity; a HAX-1 binding activity; an apoptosis suppression activity; a MAPKK stimulatory activity; a transcription modulatory activity, and a SRK-specific immunogenic activity. The invention relates to all aspects of SRK, or homologs thereof, including assays for modulators, activators, ligands, etc. The invention also relates to a cytolic or soluble HAX-1 which produces apoptosis when expressed in cells.
    Type: Application
    Filed: January 27, 2003
    Publication date: April 15, 2004
    Inventors: Rosamaria Ruggieri, Marinella Callow, Paul W. Diaz
  • Cell signaling polypeptides and nucleic acids
    Patent number: 6511825
    Abstract: The present invention relates to an isolated SRK polypeptide, biologically-active polypeptide fragments thereof, and nucleic acids which code for it. This polypeptide has various activities in regulating cell signaling and signal transduction pathways, including, e.g., a protein kinase activity; an autophosphorylating activity; a cell survival promoting activity; a HAX-1 binding activity; an apoptosis suppression activity; a MAPKK stimulatory activity; a transcription modulatory activity, and a SRK-specific immunogenic activity. The invention relates to all aspects of SRK, or homologs thereof, including assays for modulators, activators, ligands, etc. The invention also relates to a cytolic or soluble HAX-1 which produces apoptosis when expressed in cells.
    Type: Grant
    Filed: September 20, 1999
    Date of Patent: January 28, 2003
    Assignee: Onyx Pharmaceuticals, Inc.
    Inventors: Rosamaria Ruggieri, Marinella Callow, Paul W. Diaz