Patents by Inventor Paul W. Erhardt

Paul W. Erhardt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same
    Patent number: 11897852
    Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.
    Type: Grant
    Filed: February 10, 2021
    Date of Patent: February 13, 2024
    Assignee: The University of Toledo
    Inventors: Bruce E. Heck, Dong Hyun Kim, Paul W. Erhardt, Brian Kress
  • Vacuole-inducing compounds, methods of making and using the same
    Patent number: 11602531
    Abstract: Vacuole- or exosome-inducing indole-based chalcone and substituted triazole-hydrazone compounds that induce endosomal vacuolization and increase exosome yield, but do not trigger growth arrest or cell death, and methods of making and using are described.
    Type: Grant
    Filed: October 20, 2020
    Date of Patent: March 14, 2023
    Assignee: The University of Toledo
    Inventors: William A. Maltese, Zehui Li, Christopher J. Trabbic, Paul W. Erhardt
  • Analogs of proxisome proliferator activated receptor (PPAR) agonists and methods of using the same
    Patent number: 11524004
    Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.
    Type: Grant
    Filed: September 14, 2020
    Date of Patent: December 13, 2022
    Assignee: The University of Toledo
    Inventors: Bruce E. Heck, Dong Hyun Kim, Paul W. Erhardt, Brian J. Kress
  • MATERIALS AND METHODS USEFUL TO INDUCE CANCER CELL DEATH VIA METHUOSIS OR AUTOPHAGY OR A COMBINATION THEREOF
    Publication number: 20220370430
    Abstract: Compounds, compositions, and methods useful for inducing cancer cell death via methuosis, autophagy, or a combination thereof, are described. The compounds have a 4-pyridyl group linked by a heterocyclic group to an aryl, heteroaryl, aralkyl, or heteroaryl alkyl.
    Type: Application
    Filed: July 11, 2022
    Publication date: November 24, 2022
    Applicant: The University of Toledo
    Inventors: Amit K. Tiwari, Chandrabose Karthikeyan, Haneen A. Amawi, Paul W. Erhardt, Piyush Trivedi
  • Materials and methods useful to induce cancer cell death via methuosis or autophagy or a combination thereof
    Patent number: 11406626
    Abstract: Compounds, compositions, and methods useful for inducing cancer cell death via methuosis, autophagy, or a combination thereof, are described. The compounds have a 4-pyridyl group linked by a heterocyclic group to an aryl, heteroaryl, aralkyl, or heteroaryl alkyl.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: August 9, 2022
    Assignee: The University of Toledo
    Inventors: Amit K. Tiwari, Chandrabose Karthikeyan, Haneen Amawi, Paul W. Erhardt, Piyush Trivedi
  • PROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR) COMPOUNDS AND METHODS OF USING THE SAME
    Publication number: 20210163431
    Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.
    Type: Application
    Filed: February 10, 2021
    Publication date: June 3, 2021
    Applicant: The University of Toledo
    Inventors: Bruce E. Heck, Dong Hyun Kim, Paul W. Erhardt, Brian Kress
  • Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same
    Patent number: 10941125
    Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.
    Type: Grant
    Filed: July 8, 2019
    Date of Patent: March 9, 2021
    Assignee: The University of Toledo
    Inventors: Bruce E. Heck, Dong Hyun Kim, Paul W. Erhardt, Brian Kress
  • VACUOLE-INDUCING COMPOUNDS, METHODS OF MAKING AND USING THE SAME
    Publication number: 20210038586
    Abstract: Vacuole- or exosome-inducing indole-based chalcone and substituted triazole-hydrazone compounds that induce endosomal vacuolization and increase exosome yield, but do not trigger growth arrest or cell death, and methods of making and using are described.
    Type: Application
    Filed: October 20, 2020
    Publication date: February 11, 2021
    Applicant: The University of Toledo
    Inventors: William A. Maltese, Zehui Li, Christopher J. Trabbic, Paul W. Erhardt
  • Analogs of Proxisome Proliferator Activated Receptor (PPAR) Agonists and Methods of Using the Same
    Publication number: 20210038571
    Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.
    Type: Application
    Filed: September 14, 2020
    Publication date: February 11, 2021
    Applicant: The University of Toledo
    Inventors: Bruce E. Heck, Dong Hyun Kim, Paul W. Erhardt, Brian J. Kress
  • MATERIALS AND METHODS USEFUL TO INDUCE CANCER CELL DEATH VIA METHUOSIS OR AUTOPHAGY OR A COMBINATION THEREOF
    Publication number: 20200297709
    Abstract: Compounds, compositions, and methods useful for inducing cancer cell death via methuosis, autophagy, or a combination thereof, are described. The compounds have a 4-pyridyl group linked by a heterocyclic group to an aryl, heteroaryl, aralkyl, or heteroaryl alkyl.
    Type: Application
    Filed: September 26, 2018
    Publication date: September 24, 2020
    Applicant: The University of Toledo
    Inventors: Amit K. Tiwari, Chandrabose Karthikeyan, Haneen Amawi, Paul W. Erhardt, Piyush Trivedi
  • Analogs of proxisome proliferator activated receptor (PPAR) agonists and methods of using the same
    Patent number: 10776461
    Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: September 15, 2020
    Assignee: The University of Toledo
    Inventors: Bruce E. Heck, Dong Hyun Kim, Paul W. Erhardt, Brian J. Kress
  • VACUOLE-INDUCING COMPOUNDS, METHODS OF MAKING AND USING THE SAME
    Publication number: 20200000789
    Abstract: Vacuole- or exosome-inducing indole-based chalcone and substituted triazole-hydrazone compounds that induce endosomal vacuolization and increase exosome yield, but do not trigger growth arrest or cell death, and methods of making and using are described.
    Type: Application
    Filed: January 31, 2018
    Publication date: January 2, 2020
    Applicant: The University of Toledo
    Inventors: William A. Maltese, Zehui Li, Christopher J. Trabbic, Paul W. Erhardt
  • Proxisome Proliferator Activated Receptor (PPAR) Compounds and Methods of Using the Same
    Publication number: 20190330166
    Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.
    Type: Application
    Filed: July 8, 2019
    Publication date: October 31, 2019
    Applicant: The University of Toledo
    Inventors: Bruce E. Heck, Dong Hyun Kim, Paul W. Erhardt, Brian Kress
  • Analogs of Proxisome Proliferator Activated Receptor (PPAR) Agonists and Methods of Using the Same
    Publication number: 20190147147
    Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.
    Type: Application
    Filed: January 14, 2019
    Publication date: May 16, 2019
    Applicant: The University of Toledo
    Inventors: Bruce E. Heck, Dong Hyun Kim, Paul W. Erhardt, Brian J. Kress
  • Analogs of proxisome proliferator activated receptor (PPAR) agonists and methods of using the same
    Patent number: 10181018
    Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: January 15, 2019
    Assignee: The University of Toledo
    Inventors: Bruce E. Heck, Dong Hyun Kim, Paul W. Erhardt, Brian J. Kress
  • ANALOGS OF PROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR) AGONISTS AND METHODS OF USING THE SAME
    Publication number: 20180012002
    Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.
    Type: Application
    Filed: September 8, 2017
    Publication date: January 11, 2018
    Applicant: The University of Toledo
    Inventors: Bruce E. Heck, Dong Hyun Kim, Paul W. Erhardt, Brian J. Kress
  • Inhibitors of ERCC1-XPF and methods of using the same
    Patent number: 9821008
    Abstract: Compositions and methods for inhibiting the DNA repair protein complex, ERCC1-XPF, and methods to enhance clinical responses to anticancer drugs that interact with DNA such as cisplatin, and to overcome drug resistance due to DNA repair mechanisms, are described.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: November 21, 2017
    Assignee: The University of Toledo
    Inventors: Stephan M. Patrick, Paul W. Erhardt, Christopher Trabbic
  • Target for Anthelmintic Development, and Anthelmintics Utilizing the Same
    Publication number: 20170311599
    Abstract: Compounds, compositions, methods, materials, and transgenic animals for antihelmintic purposes are described.
    Type: Application
    Filed: April 28, 2017
    Publication date: November 2, 2017
    Applicant: The University of Toledo
    Inventors: Richard Komuniecki, Bruce Bamber, Paul W. Erhardt
  • INHIBITORS OF ERCC1-XPF AND METHODS OF USING THE SAME
    Publication number: 20160296556
    Abstract: Compositions and methods for inhibiting the DNA repair protein complex, ERCC1-XPF, and methods to enhance clinical responses to anticancer drugs that interact with DNA such as cisplatin, and to overcome drug resistance due to DNA repair mechanisms, are described.
    Type: Application
    Filed: November 25, 2014
    Publication date: October 13, 2016
    Applicant: The University of Toledo
    Inventors: Stephan M. PATRICK, Paul W. ERHARDT, Christopher TRABBIC
  • Materials and methods useful to induce vacuolization, cell death, or a combination thereof
    Patent number: 9061994
    Abstract: The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism, to induce vacuolization without cell death, or to induce cell death without vacuolization. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: June 23, 2015
    Assignee: The University of Toledo
    Inventors: William A. Maltese, Paul W. Erhardt, Jean H. Overmeyer, Christopher Trabbic