Patents by Inventor Paul W. J. J. Burgman

Paul W. J. J. Burgman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Uses of DNA-PK
    Patent number: 7700568
    Abstract: This invention provides methods for increasing the susceptibility of cells to DNA-damaging agents, and for treating tumors in a subject, comprising introducing antisense that prevent expression of DNA dependent protein kinase catalytic subunit Ku70 or Ku80, wherein the antisense is in an amount sufficient to increase the sensitivity of the cells and tumors to heat, chemical, or radiation-induced DNA damage.
    Type: Grant
    Filed: December 28, 2000
    Date of Patent: April 20, 2010
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Gloria C. Li, Paul W. J. J. Burgman
  • Uses of DNA-PK
    Patent number: 7592319
    Abstract: This invention provides a method for increasing the susceptibility of a cell to DNA-damaging agents, comprising introducing into the cell an antisense oligonucleotide that specifically hybridizes to a nucleic acid encoding a DNA dependent protein kinase subunit so as to prevent expression of the DNA dependent protein kinase subunit; wherein the antisense oligonucleotide is in an amount sufficient to increase the sensitivity of the cell to heat, chemical, or radiation-induced DNA damage; and wherein the DNA dependent protein kinase subunit is a DNA dependent protein kinase catalytic subunit, a Ku70, or a Ku80.
    Type: Grant
    Filed: November 12, 2003
    Date of Patent: September 22, 2009
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Gloria C. Li, Paul W. J. J. Burgman
  • Uses of DNA-PK
    Publication number: 20030083276
    Abstract: This invention provides a method for increasing the susceptibility of a cell to DNA-damaging agents, comprising introducing into the cell an antisense oligonucleotide that specifically hybridizes to a nucleic acid encoding a DNA dependent protein kinase subunit so as to prevent expression of the DNA dependent protein kinase subunit; wherein the antisense oligonucleotide is in an amount sufficient to increase the sensitivity of the cell to heat, chemical, or radiation-induced DNA damage; and wherein the DNA dependent protein kinase subunit is a DNA dependent protein kinase catalytic subunit, a Ku70, or a Ku80.
    Type: Application
    Filed: December 28, 2000
    Publication date: May 1, 2003
    Inventors: Gloria C. Li, Paul W.J.J. Burgman