Patents by Inventor Paul W.M. FEDAK

Paul W.M. FEDAK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AORTA-SPECIFIC DNA METHYLATION PATTERNS IN CELL-FREE DNA FROM PATIENTS WITH BICUSPID AORTIC VALVE-ASSOCIATED AORTOPATHY
    Publication number: 20230265493
    Abstract: Described herein is a method of determining the risk of a human subject with congenital BAV having BAV-associated aortopathy or developing BAV-associated aortopathy, comprising: obtaining a cell free DNA (cfDNA) sample from the subject, measuring the level of methylation of a methylation marker that is associated with BAV-associated aortopathy in the cfDNA sample, optionally comparing the level of methylation of the methylation maker in the sample of the subject with a comparator control, wherein when the methylation marker is hypo- or hypermethylated the subject as being at risk of developing BAV-associated aortopathy.
    Type: Application
    Filed: December 16, 2022
    Publication date: August 24, 2023
    Inventors: Steven GREENWAY, Paul W.M. FEDAK, Ashna Karimbhai MAREDIA, Mohammad ALEINATI