Patents by Inventor Paul W. Sternberg

Paul W. Sternberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • UTILITY OF NEMATODE SMALL MOLECULES
    Publication number: 20240018177
    Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.
    Type: Application
    Filed: June 12, 2023
    Publication date: January 18, 2024
    Inventors: Andrea Choe, Paul W. Sternberg, Frank C. Schroeder, Stephan H. von Reuss
  • Utility of nematode small molecules
    Patent number: 11673908
    Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.
    Type: Grant
    Filed: August 1, 2022
    Date of Patent: June 13, 2023
    Assignees: California Institute of Technology, Boyce Thompson Institute for Plant Research
    Inventors: Andrea Choe, Paul W. Sternberg, Frank C. Schroeder, Stephan H. Von Reuss
  • UTILITY OF NEMATODE SMALL MOLECULES
    Publication number: 20230024046
    Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.
    Type: Application
    Filed: August 1, 2022
    Publication date: January 26, 2023
    Inventors: Andrea Choe, Paul W. Sternberg, Frank C. Schroeder, Stephan H. Von Reuss
  • ASCAROSIDE TREATMENT OF EOSINOPHILIC ESOPHAGITIS
    Publication number: 20230026686
    Abstract: A method of preventing or treating eosinophilic esophagitis (EoE) comprising administering a composition comprising ascr #7 is described.
    Type: Application
    Filed: September 9, 2022
    Publication date: January 26, 2023
    Inventors: Andrea CHOE, Paul W. Sternberg, Frank C. Schroeder
  • Ascaroside treatment of eosinophilic esophagitis
    Patent number: 11464810
    Abstract: A method of preventing or treating eosinophilic esophagitis (EoE) comprising administering a composition comprising ascr#7 is described.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: October 11, 2022
    Assignees: California Institute of Technology, Boyce Thompson Institute for Plant Research
    Inventors: Andrea Choe, Paul W. Sternberg, Frank C. Schroeder
  • ASCAROSIDE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES
    Publication number: 20220016182
    Abstract: The present invention relates to the use of ascr#7 for preventing or treating IL-6 and/or IL-1?-mediated diseases.
    Type: Application
    Filed: July 30, 2021
    Publication date: January 20, 2022
    Inventors: Andrea Choe, Paul W. Sternberg, Frank C, Schroeder
  • Ascaroside treatment of autoimmune and inflammatory diseases
    Patent number: 11077151
    Abstract: The present invention relates to the use of ascr #7 for preventing or treating IL-6 and/or IL-1?-mediated diseases.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: August 3, 2021
    Assignees: California Institute of Technology, Boyce Thompson Institute for Plant Research
    Inventors: Andrea Choe, Paul W. Sternberg, Frank C. Schroeder
  • UTILITY OF NEMATODE SMALL MOLECULES
    Publication number: 20200262856
    Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.
    Type: Application
    Filed: November 15, 2019
    Publication date: August 20, 2020
    Inventors: Andrea Choe, Paul W. Sternberg, Frank C. Schroeder, Stephan H. Von Reuss
  • Utility of nematode small molecules
    Patent number: 10479813
    Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: November 19, 2019
    Assignees: California Institute of Technology, Boyce Thompson Institute for Plant Research
    Inventors: Andrea Choe, Paul W. Sternberg, Frank C. Schroeder, Stephan H. Von Reuss
  • ASCAROSIDE TREATMENT OF EOSINOPHILIC ESOPHAGITIS
    Publication number: 20190192578
    Abstract: A method of preventing or treating eosinophilic esophagitis (EoE) comprising administering a composition comprising ascr#7 is described.
    Type: Application
    Filed: August 25, 2017
    Publication date: June 27, 2019
    Inventors: Andrea Choe, Paul W. Sternberg, Frank C. Schroeder
  • ASCAROSIDE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES
    Publication number: 20190175663
    Abstract: The present invention relates to the use of ascr#7 for preventing or treating IL-6 and/or IL-1?-mediated diseases.
    Type: Application
    Filed: August 25, 2017
    Publication date: June 13, 2019
    Inventors: Andrea Choe, Paul W. Sternberg, Frank C. Schroeder
  • UTILITY OF NEMATODE SMALL MOLECULES
    Publication number: 20190153014
    Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.
    Type: Application
    Filed: January 18, 2019
    Publication date: May 23, 2019
    Inventors: Andrea Choe, Paul W. Sternberg, Frank C. Schroeder, Stephan H. Von Reuss
  • Utility of nematode small molecules
    Patent number: 10183963
    Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: January 22, 2019
    Assignees: California Institute of Technology, Boyce Thompson Institute for Plant Research
    Inventors: Andrea Choe, Paul W. Sternberg, Frank C. Schroeder, Stephan H. Von Reuss
  • Utility of nematode small molecules
    Patent number: 9868754
    Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.
    Type: Grant
    Filed: August 8, 2012
    Date of Patent: January 16, 2018
    Assignees: California Institute of Technology, Boyce Thompson Institute for Plant Research
    Inventors: Andrea Choe, Paul W. Sternberg, Frank C. Schroeder, Stephan H. Von Reuss
  • Small molecule compounds that control plant- and insect-pathogenic nematodes
    Patent number: 9534008
    Abstract: The present invention relates to methods of modifying nematode behavior using certain isolated modulator compounds. Also disclosed are methods of promoting or inhibiting reproduction in a nematode population, methods of promoting or inhibiting nematode aggregation at a first location, and methods of treating or preventing parasite infection of a plant.
    Type: Grant
    Filed: August 8, 2012
    Date of Patent: January 3, 2017
    Assignees: California Institute of Technology, Boyce Thompson Institute for Plant Research, The United States of America, As Represented by the Secretary of Agriculture
    Inventors: Andrea Choe, Paul W. Sternberg, Frank C. Schroeder, Stephan H. Von Reuss, Fatma Kaplan, Peter A. Teal, Hans Alborn
  • Small molecule compounds that control mammal-pathogenic nematodes
    Patent number: 9487551
    Abstract: The present invention relates to methods of modifying nematode behavior using certain isolated modulator compounds. Also disclosed are methods of promoting or inhibiting reproduction in a nematode population, methods of promoting or inhibiting nematode aggregation at a mammal, and methods of treating or preventing parasite infection of a mammal.
    Type: Grant
    Filed: August 8, 2012
    Date of Patent: November 8, 2016
    Assignees: California Institute of Technology, Boyce Thompson Institute for Plant Research, The Regents of the University of California
    Inventors: Andrea Choe, Paul W. Sternberg, Frank C. Schroeder, Stephan H. Von Reuss, Raffi V. Aroian
  • Small molecule compounds for the control of nematodes
    Patent number: 9445596
    Abstract: The present invention relates to compounds involved in nematode signaling.
    Type: Grant
    Filed: August 8, 2012
    Date of Patent: September 20, 2016
    Assignees: California Institute of Technology, Boyce Thompson Institute for Plant Research
    Inventors: Frank C. Schroeder, Stephan H. von Reuss, Andrea Choe, Paul W. Sternberg
  • Compositions and Methods Related to Parasites
    Publication number: 20150329603
    Abstract: In some aspects, the invention relates to compositions and methods for preventing or treating a hookworm infection. In some aspects, the invention relates to nucleic acids, peptides, proteins, antigens, and cells that encode, comprise, and/or express one or more hookworm amino acid sequences, e.g., for use in manufacturing a vaccine.
    Type: Application
    Filed: May 13, 2015
    Publication date: November 19, 2015
    Inventors: Erich M. Schwarz, Yan Hu, Igor Antoshechkin, Paul W. Sternberg, Raffi V. Aroian
  • COMPOSITIONS AND METHODS FOR MODULATING SLEEP AND WAKEFULNESS
    Publication number: 20150246140
    Abstract: In some aspects, the invention relates to methods of treating conditions associated with sleep disorders, comprising administering an agent that modulates the activity of a neuropeptide receptor or a neuropeptide receptor ligand. In some aspects, the invention relates to methods of screening agents that modulate the activity of a neuropeptide receptor in an organism, optionally using cells or organisms comprising a genetic modification that affects a neuropeptide signaling pathway. In some aspects, the invention relates to methods of characterizing a condition associated with a sleep disorder comprising sequencing a nucleic acid encoding either a neuropeptide receptor or a neuropeptide receptor ligand and comparing the sequence with a reference sequence.
    Type: Application
    Filed: February 10, 2015
    Publication date: September 3, 2015
    Applicant: California Institute of Technology
    Inventors: Suk Hen Chow, Daniel A. Lee, David A. Prober, Paul W. Sternberg
  • The Utility of Nematode Small Molecules
    Publication number: 20150018291
    Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.
    Type: Application
    Filed: August 8, 2012
    Publication date: January 15, 2015
    Applicants: Boyce Thompson institute for Plant Research, California Institute of Technology
    Inventors: Andrea Choe, Paul W. Sternberg, Frank C. Schroeder