Patents by Inventor Paul Watt
Paul Watt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250041827Abstract: This disclosure relates to liquid dispersion compositions that are suitable to provide absorbent materials (e.g., an absorbent coating), and methods of preparing the compositions and absorbent materials thereof.Type: ApplicationFiled: August 2, 2024Publication date: February 6, 2025Inventors: Steven Edward Brown, Paul Sevier McClellan, JR., Bradlee Watts Gustavesen, Jason Randall
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Patent number: 12219417Abstract: A wireless transmit/receive unit (WTRU) may comprise a processor. The processor may be configured to receive (e.g., via broadcast) configuration information indicating a time that a same-PCI satellite switch may occur. In one or more examples, the WTRU may transmit assistance information prior to the same-PCI satellite switch. The assistance information may, for example, include a re-synchronization duration, capabilities to synchronization procedures, and/or a time indication for resuming TX and/or RX. The WTRU may receive configuration information for satellite re-synchronization. The WTRU may perform the same-PCI satellite switch to the second satellite, for example, based on the configuration information indicating the time for the same-PCI satellite switch. In performing the same-PCI satellite switch, the WTRU may start a resynchronization gap, suspend UL TX and/or DL RX, and/or perform re-synchronization procedure(s).Type: GrantFiled: July 1, 2024Date of Patent: February 4, 2025Assignee: InterDigital Patent Holdings, Inc.Inventors: Dylan Watts, Paul Marinier, Moon Il Lee, Brian Martin, Oumer Teyeb
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Patent number: 12207108Abstract: A wireless transmit/receive unit (WTRU) may determine a first set of beams and a second set of beams, that a respective quality of each beam in the first set of beams is less than a predetermined quality value, and that a beam that is in the second set of beams and not in the first set of beams has a quality that is equal to or greater than the predetermined quality value. The WTRU may select the beam that is in the second set of beams and not in the first set of beams and whose quality is equal to or greater than the predetermined quality value, for a BFR and send a message that indicates the selected beam for the BFR to abase station (e.g., a gNodeB). The WTRU may receive a message comprising the selected beam from the gNodeB.Type: GrantFiled: August 12, 2020Date of Patent: January 21, 2025Assignee: InterDigital Patent Holdings, Inc.Inventors: Erdem Bala, Paul Marinier, Moon-il Lee, Dylan Watts
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Publication number: 20240430959Abstract: A system (1600) and method (960) for utilizing data from on-vehicle and off-vehicle sources to identify problematic devices and to execute automated mitigations is disclosed herein. The system (1620) comprises assigning authority engine (1105) for a vehicle (1000), a device (110) for the vehicle (1000), one or more databases (1615), and more or more cloud sources (1175). The assigning authority engine (1105) is configured to analyze the data based on a plurality of pre-defined patterns to identify a malfunctioning device and to transmit a mitigation strategy for the malfunctioning device.Type: ApplicationFiled: August 28, 2024Publication date: December 26, 2024Applicant: Platform Science, Inc.Inventors: Rio Jeane Abella, Scott Kopchinsky, Don Son, Paul Watts, Kevin O'Neil, Neth Maison
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Publication number: 20240410753Abstract: A system for screening of pathogens or gene differences includes first and second screening modes and a source of electromagnetic radiation for illuminating a plurality of samples. The source of electromagnetic radiation has a selectable illumination property. The system also may include a detector for detecting electromagnetic radiation transmitted through or emitted by the plurality of samples with the detector having a selectable detection property. The system may be arranged for concurrent operation in the first and the second mode. The first screening mode may be a fluorometric screening mode and the second optional screening mode may be a colorimetric screening mode.Type: ApplicationFiled: August 25, 2022Publication date: December 12, 2024Inventors: Anthony Stevens, Paul Watt, Paul Ostergaard, Tatjana Heinrich, Robert Dewhurst
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Publication number: 20240368136Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-8 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.Type: ApplicationFiled: October 19, 2023Publication date: November 7, 2024Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Valerio BERDINI, Ildiko Maria BUCK, James Edward Harvey DAY, Charlotte Mary GRIFFITHS-JONES, Thomas Daniel HEIGHTMAN, Steven HOWARD, Christopher William MURRAY, David NORTON, Marc O'REILLY, Alison Jo-Anne WOOLFORD, Michael Liam COOKE, David COUSIN, Stuart Thomas ONIONS, Jonathan Martin SHANNON, John Paul WATTS
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Publication number: 20240368129Abstract: The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.Type: ApplicationFiled: May 7, 2024Publication date: November 7, 2024Inventors: David HARRISON, Alan Paul WATT, Mark G. BOCK
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Publication number: 20240343686Abstract: This invention provides for a flow synthesis process for producing sulfonylurea compounds of formula (1), including glipizide and glibenclamide, and pharmaceutically acceptable salts thereof.Type: ApplicationFiled: August 12, 2022Publication date: October 17, 2024Inventors: Agnes Zvinaiye KHASIPO, Cloudius Ray SAGANDIRA, Paul WATTS
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Patent number: 12120754Abstract: A system (1600) and method (960) for utilizing data from on-vehicle and off-vehicle sources to identify problematic devices and to execute automated mitigations is disclosed herein. The system (1620) comprises assigning authority engine (1105) for a vehicle (1000), a device (110) for the vehicle (1000), one or more databases (1615), and more or more cloud sources (1175). The assigning authority engine (1105) is configured to analyze the data based on a plurality of pre-defined patterns to identify a malfunctioning device and to transmit a mitigation strategy for the malfunctioning device.Type: GrantFiled: April 11, 2022Date of Patent: October 15, 2024Assignee: Platform Science, Inc.Inventors: Rio Jeane Abella, Scott Kopchinsky, Don Son, Paul Watts, Kevin O'Neil, Neth Maison
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Patent number: 12012397Abstract: The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.Type: GrantFiled: October 17, 2022Date of Patent: June 18, 2024Assignee: NodThera LimitedInventors: David Harrison, Alan Paul Watt, Mark G. Bock
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Patent number: 11939321Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.Type: GrantFiled: April 7, 2021Date of Patent: March 26, 2024Assignee: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Valerio Berdini, Ildiko Maria Buck, James Edward Harvey Day, Charlotte Mary Griffiths-Jones, Thomas Daniel Heightman, Steven Howard, Christopher William Murray, David Norton, Marc O'Reilly, Alison Jo-Anne Woolford, Michael Liam Cooke, David Cousin, Stuart Thomas Onions, Jonathan Martin Shannon, John Paul Watts
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Publication number: 20230408536Abstract: An automated analyser for high-throughput assay testing for the presence of a biological or biochemical substance includes a plurality of sample process stations to receive analysis vessels and perform one or more processing or analysis steps on samples retained in the analysis vessels and including at least an incubation station to receive a plurality of the analysis vessels, provide illumination to each sample of each analysis vessel in the incubation field, and maintain the plurality of analysis vessels at predetermined incubation temperatures. The analyser includes an analysis vessel transfer system to transfer analysis vessels between the process stations, an imaging system to image illuminated samples in the analysis vessels retained in the incubation field, and a resource controller.Type: ApplicationFiled: October 15, 2021Publication date: December 21, 2023Inventors: Paul OSTERGAARD, Paul WATT
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Publication number: 20230278989Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.Type: ApplicationFiled: January 25, 2023Publication date: September 7, 2023Applicants: ASTEX THERAPEUTICS LIMITED, CANCER RESEARCH TECHNOLOGY LIMITEDInventors: Steven HOWARD, Benjamin David CONS, Jeffrey David ST. DENIS, Charlotte Mary GRIFFITHS-JONES, Steven Douglas HISCOCK, Rhian Sara HOLVEY, Alan Richard BURNS, David COUSIN, Hannah Louise DEXTER, Guillaume François PARRA, John Paul WATTS, Robert JEWELL, Jennifer Ann STOCKWELL, Kim Louise HIRST, Isabelle Anne LEMASSON, David John NASH, James Daniel OSBORNE, Jonas Calleja PRIEDE, Nicholas Paul RICHARDS, Aaron Michael DUMAS, Brian Christopher BISHOP, David PARRY-JONES, Jeremy Peter SCOTT, Meenakshi Sundaram SHANMUGHAM, Peter Richard MULLENS, David Charles LATHBURY, Darren James DIXON, Matthew James GAUNT
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Publication number: 20230145050Abstract: The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.Type: ApplicationFiled: October 17, 2022Publication date: May 11, 2023Inventors: David HARRISON, Alan Paul WATT, Mark G. BOCK
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Publication number: 20230142405Abstract: A multistep continuous flow synthesis method for the manufacture of isonicotinyl-hydrazide (Isoniazid) comprising reacting 4-cyano pyridine with NaOH at a specified molar ratio and temperature range to produce the intermediate isonicotinamide, which intermediate is reacted with hydrazine hydrate, without isolation thereof, at a specified molar ratio and temperature range to produce isonicotinyl-hydrazide (Isoniazid) in a yield greater than about 90%.Type: ApplicationFiled: April 23, 2020Publication date: May 11, 2023Applicant: NELSON MANDELA UNIVERSITYInventors: Paul WATTS, Ruvimbo MANGWIRO
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Publication number: 20230019032Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.Type: ApplicationFiled: April 7, 2021Publication date: January 19, 2023Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Valerio BERDINI, Ildiko Maria BUCK, James Edward Harvey DAY, Charlotte Mary GRIFFITHS-JONES, Thomas Daniel HEIGHTMAN, Steven HOWARD, Christopher William MURRAY, David NORTON, Marc O'REILLY, Alison Jo-Anne WOOLFORD, Michael Liam COOKE, David COUSIN, Stuart Thomas ONIONS, Jonathan Martin SHANNON, John Paul WATTS
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Patent number: 11518757Abstract: The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.Type: GrantFiled: December 18, 2018Date of Patent: December 6, 2022Assignee: NodThera LimitedInventors: David Harrison, Alan Paul Watt, Mark G. Bock
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Publication number: 20220330353Abstract: A system (1600) and method (960) for utilizing data from on-vehicle and off-vehicle sources to identify problematic devices and to execute automated mitigations is disclosed herein. The system (1620) comprises assigning authority engine (1105) for a vehicle (1000), a device (110) for the vehicle (1000), one or more databases (1615), and more or more cloud sources (1175). The assigning authority engine (1105) is configured to analyze the data based on a plurality of pre-defined patterns to identify a malfunctioning device and to transmit a mitigation strategy for the malfunctioning device.Type: ApplicationFiled: April 11, 2022Publication date: October 13, 2022Applicant: Platform Science, Inc.Inventors: Rio Jeane Abella, Scott Kopchinsky, Don Son, Paul Watts, Kevin O'Neil, Neth Maison
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Patent number: 11345669Abstract: The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein inhibit the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inter alia autoinflammatory and autoimmune diseases and cancers.Type: GrantFiled: March 12, 2018Date of Patent: May 31, 2022Assignee: NodThera LimitedInventors: David Harrison, Alan Paul Watt, Nicolas Boutard, Charles-Henry Fabritius, Michal Galezowski, Piotr Kowalczyk, Oleksandr Levenets, Jakub Woyciechowski
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Publication number: 20220144756Abstract: This invention provides for a flow synthesis process for producing Oseltamivir and pharmaceutically acceptable salts thereof from shikimic acid in particular but not exclusively to a flow synthesis process for producing Oseltamivir phosphate from shikimic acid in a nine-step flow synthesis that provides for superior reaction times and product yields compared to known methods.Type: ApplicationFiled: February 28, 2020Publication date: May 12, 2022Applicant: Nelson Mandela UniversityInventors: Cloudius Ray Sagandira, Paul Watts