Abstract: Vacuum pump (1), comprising a housing (2) having an inlet (4) and an outlet (6) and defining a chamber (8) within the housing (2), a rotor (10) for rotational movement about a rotational axis (AR) within the chamber (8), and at least a first and a second vane (22, 24) received in respective first and seconds slots (16, 18) formed in the rotor (10). The first and second slots (16, 18) are substantially parallel to each other, and a length (LV) of each vane (22, 24) is larger than a length (LS) of the respective slot. Production method of such a vacuum pump.

Abstract: Vacuum pump (1), comprising a housing (2) having an inlet (4) and an outlet (6) and defining a chamber (8) within the housing (2), a rotor (10) for rotational movement about a rotational axis (AR) within the chamber (8), and at least a first and a second vane (22, 24) received in respective first and seconds slots (16, 18) formed in the rotor (10). The first and second slots (16, 18) are substantially parallel to each other, and a length (LV) of each vane (22, 24) is larger than a length (LS) of the respective slot. Production method of such a vacuum pump.

Abstract: The internalization sequence at the C-terminal end of the ROMK protein has been identified and sequenced. It has been discovered determined that endocytosis is triggered by binding of the ROMK internalization sequence to ARH protein, which is co-localized and expressed with ROMK. New methods of treating or preventing hyperkalemia have been discovered that include administering to a patient who is at risk of developing hyperkalemia or who has hyperkalemia, a therapeutically effective amount of an agent that blocks the interaction of the ROMK internalization sequence with ARH protein, thereby preventing or reducing ARH-induced endocytosis of ROMK.

Abstract: The internalization sequence at the C-terminal end of the ROMK protein has been identified and sequenced. It has been discovered determined that endocytosis is triggered by binding of the ROMK internalization sequence to ARH protein, which is co-localized and expressed with ROMK. New methods of treating or preventing hyperkalemia have been discovered that include administering to a patient who is at risk of developing hyperkalemia or who has hyperkalemia, a therapeutically effective amount of an agent that blocks the interaction of the ROMK internalization sequence with ARH protein, thereby preventing or reducing ARH-induced endocytosis of ROMK.