Abstract: The present invention relates to pharmaceutical compositions comprising antibodies capable of binding a human V?9V?2 T cell receptor. The invention further relates to uses of the pharmaceutical compositions of the invention for medical treatment.

Abstract: Systems, methods, and articles of manufacture, including computer program products, provide a system including at least one data processor and at least one memory storing instructions which, when executed by the at least one data processor, cause operations comprising: generating, by a database execution engine, a query plan including a plurality of operators; inserting, by the database execution engine, an enforce compilation operator into the query plan that includes the plurality of operators, the plurality of operators comprising a first operator, the enforce compilation operator, and a second operator; executing at least the first operator of the query plan; in response to executing the first operator, evaluating, by the database execution engine, an output of the first operator to determine whether a condition is satisfied; and in response to the condition being satisfied, triggering, by the database execution engine, a just-in-time compilation of the second operator.

Abstract: The present invention relates to novel uses of gamma delta T-cell activating antibodies, in particular uses of such antibodies in patients that are also being treated, or have recently been treated, with aminobisphosphonates, or other inhibitors of the mevalonate pathway that inhibit farnesyl pyrophosphate synthase or an enzyme further downstream in the mevalonate pathway.

Abstract: A method for allocating worker threads may include receiving a first fetch call for a query accessing a dataset stored at a database. The first fetch call may require a first portion of a result for the query. A first quantity of worker threads may be allocated to generate the first portion of the result for the query in response to the first fetch call. In response to a second fetch call for the query by determining a threshold corresponding to the first quantity of worker threads, a second quantity of data required for the second fetch call, and a third quantity of data buffered from the first fetch call. A second quantity of worker threads to generate a second portion of the result for the query may be allocated based on the threshold. Related systems and computer program products are also provided.

Abstract: In some implementations, there is provided executing a query execution plan for a query; setting a first flag to indicate to a plurality of worker threads to stop executing tasks in a first queue of a memory stack; pushing into the memory stack, a second queue containing one or more exclusive tasks associated with the query; setting a second flag to indicate to the plurality of worker threads to resume working; and in response to the second queue being empty of the one or more exclusive tasks, setting a third flag to indicate to the plurality of worker threads to stop executing tasks in the second queue, and setting a fourth flag to indicate to the plurality of worker threads to resume working on the tasks in the first queue.

Abstract: Systems, methods, and articles of manufacture, including computer program products, provide a system including at least one data processor and at least one memory storing instructions which, when executed by the at least one data processor, cause operations comprising: generating, by a database execution engine, a query plan including a plurality of operators; inserting, by the database execution engine, an enforce compilation operator into the query plan that includes the plurality of operators, the plurality of operators comprising a first operator, the enforce compilation operator, and a second operator; executing at least the first operator of the query plan; in response to executing the first operator, evaluating, by the database execution engine, an output of the first operator to determine whether a condition is satisfied; and in response to the condition being satisfied, triggering, by the database execution engine, a just-in-time compilation of the second operator.

Abstract: In some implementations, there is provided pipeline bypassing of certain operators. In some implementations, a method includes generating a query plan including at least one pipeline of operators; determining whether the at least one pipeline of operators includes a first operator that requires a complete result set as an input and further includes a second operator that supports providing the complete result set using a state identified by a state reference; and in response to determining the at least one pipeline of operators includes the first operator that requires the complete result set as the input and further includes the second operator that supports providing the complete result set using the state identified by the state reference, bypassing in the query plan pipelining between the first operator and the second operator.

Abstract: In some implementations, there is provided a method that includes receiving a query request including a top k query operator for query plan generation, optimization, and execution, wherein k defines a threshold limit of query results for the top k query operator; inserting into a query plan a check operator associated with the top k query operator; in response to executing the query plan, checking, by the check operator, whether an early exit occurs due to the top k query operator reaching the threshold limit; in response to the early exit occurring due to the top k query operator reaching the threshold limit, stopping processing, by the check operator, including opening of another fragment of a database table; and in response to the early exit not occurring, allowing, by the check operator, the opening of the other fragment of the database table.

Abstract: In some implementations, there is provided a method including generating a query plan including in a first pipeline a first join operator and in a second pipeline a second join operator; executing at least a portion of the query plan including the first pipeline and the first join operator; detecting, based on the at least one operator usage state and the at least one operator pruning condition, an empty state object shared between the first join operator and the second join operator in the second pipeline; and processing, by the at least one operator pruning condition, an indication of the empty state object, wherein the least one operator pruning condition is associated with the second join operator and includes at least a first rule to mark the second join operator for pruning.

Abstract: In some implementations, there is provided a method that includes receiving a query request including a top k query operator for query plan generation, optimization, and execution, wherein k defines a threshold limit of query results for the top k query operator; inserting into a query plan a check operator associated with the top k query operator; in response to executing the query plan, checking, by the check operator, whether an early exit occurs due to the top k query operator reaching the threshold limit; in response to the early exit occurring due to the top k query operator reaching the threshold limit, stopping processing, by the check operator, including opening of another fragment of a database table; and in response to the early exit not occurring, allowing, by the check operator, the opening of the other fragment of the database table.

Abstract: A method for performing a parallelized heapsort operation may include updating, by a first worker thread, a first buffer while a second worker thread updates a second buffer in parallel. The first worker thread may update the first buffer by adding, to the first buffer, elements from a first partition of a dataset. The second worker thread may update the second buffer by adding, to the second buffer, elements from a second partition of the dataset. Upon the first buffer reaching a threshold size, the first worker thread may acquire a lock for the first worker thread to update a heap based on the first buffer while the second worker thread is prevented from updating the heap based on the second buffer. A result of a top k query comprising a k quantity of smallest elements from the dataset may be generated based on the heap.

Abstract: A system and/or method for spill-to-disk in projection operations includes receiving a query including a projection, receiving a plurality of rows in response to the query processed by a processing thread of a plurality of processing threads, determining whether the query specifies an order for the plurality of rows, determining whether a disk buffer associated with the processing thread contains a stored row in response to the query specifying the order, storing the plurality of rows in the disk buffer in response to determining the disk buffer contains the stored row, storing the plurality of rows in a memory buffer associated with the processing thread in response to determining the disk buffer does not contain the stored row and the memory buffer contains at least a threshold amount of memory to store the plurality of rows, and providing the stored plurality of rows in response to the query.

Abstract: In some implementations, there is provided a method that includes detecting in a query plan a pipeline that includes a last restart query operator that can cause a retry of the query plan during execution of the query plan; configuring the pipeline to execute the pipeline using an open call configuration, configuring at least one subsequent pipeline to execute in a fetch call configuration; executing the query plan including the pipeline in the open call configuration; sending, by the send operator, a message indicating the last restart query operator cannot cause a retry of the execution of the query plan; and causing execution of at least one operator in the subsequent pipeline to execute in the fetch call configuration, in which result streaming of partial results is allowed for the at least one operator.

Abstract: The invention relates to multispecific antibodies and pharmaceutical compositions comprising said antibodies, to processes for the preparation of said antibodies and to the use of said antibodies targeting CD33 and to their use in the treatment of diseases, e.g., cancer.

Abstract: In some example embodiments, there is provided a method that includes receiving a query for query plan generation and query plan optimization; detecting whether the query plan includes a restart pipeline, the restart pipeline including one or more first operators that cause a query plan restart; detecting whether the query plan includes a result pipeline, the result pipeline including one or more second operators that provide result streaming; determining whether there is a dependency between execution of the restart pipeline and execution of the result pipeline; in response to determining there is no dependency, reordering the restart pipeline in the query plan such that the restart pipeline will be executed before the result pipeline in order to enable result streaming optimization; and providing the reordered query plan for execution. Related systems and computer program products are also provided.

Abstract: A method for allocating worker threads may include receiving a first fetch call for a query accessing a dataset stored at a database. The first fetch call may require a first portion of a result for the query. A first quantity of worker threads may be allocated to generate the first portion of the result for the query in response to the first fetch call. In response to a second fetch call for the query by determining a threshold corresponding to the first quantity of worker threads, a second quantity of data required for the second fetch call, and a third quantity of data buffered from the first fetch call. A second quantity of worker threads to generate a second portion of the result for the query may be allocated based on the threshold. Related systems and computer program products are also provided.

Abstract: In some implementations, there is provided receiving a query request including a top k query operator for query plan generation, optimization, and execution; generating a query plan that includes at least one pipeline of a plurality of operators, wherein the at least one pipeline is associated with a directed acyclic graph; detecting in the query plan a first operator in the at least one pipeline that causes an early exit; and in response to the early exit by the first operator during query execution, processing back through the directed acyclic graph to identify at least one preceding operator that should or should not run given the early exit of the first operator.

Abstract: A method for executing a dynamically generated operation in a parallel processing framework may include executing the dynamically generated operation sequentially for a threshold quantity of times before initiating a compilation operation to generate precompiled code for the dynamically generated operation. Upon generating the precompiled code, execution of the precompiled code may be parallelized by determining, based on a quantity of time required to execute the precompiled code on a portion of a dataset, a task size. The execution of the precompiled code may be divided, based on the task size, into one or more tasks. Moreover, a corresponding quantity of worker threads may be allocated to perform the one or more tasks in parallel. Related methods and computer program products are also provided.

Abstract: A method for on-demand access to table partitions may include receiving, at a data execution engine, a query accessing a database table divided into a first partition and a second partition stored at different nodes of the database. The data execution engine may respond to the query by acquiring a lock on the database table and instantiating data structures to support the execution of the query without loading any of the partitions of the database table into a main memory. Instead, the loading of the individual partitions of the database table may be delegated to the operators tasked with performing the operations included in the execution plan for the query. Each operator may refrain from loading those partitions of the database table that are determined to be unnecessary for performing the individual operations. Related systems and computer program products are also provided.

Abstract: The present invention relates to antibodies capable of binding human PSMA and capable of binding a human V?9V?2 T cell receptor. The invention further relates to pharmaceutical compositions comprising the antibodies of the invention and to uses of the antibodies of the invention for medical treatment.