Patents by Inventor Paul William Peterson

Paul William Peterson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Devices, systems and methods for endovascular temperature control
    Patent number: 11951035
    Abstract: Devices, systems and methods for controlling a patient's body temperature by endovascular heat exchange.
    Type: Grant
    Filed: August 11, 2021
    Date of Patent: April 9, 2024
    Assignee: ZOLL Circulation, Inc.
    Inventors: Jeremy Thomas Dabrowiak, Jessica Megan Clayton, John Thomas Buckley, Christo P. Pamichev, Craig Wendell Pendry, Paul Eric Peterson, Richard Allen Smith, Sean W. Yip, John William Jacobsen
  • Controlled cyclization of peptoids to form chiral diketopiperazines
    Patent number: 11084794
    Abstract: The present disclosure provides improved methods for controlled cyclization of peptoid dimers to form N,N?-2,5-diketopiperazines (N,N?-2,5-DKPs) with significant selectivity. In at least some examples, selectivity is based on a serendipitous conglomeration of slow exchange of amide rotamers, steric repulsion from the degree of ?-substitution, and the geometric bulk of an amine nucleophile. By varying reaction conditions, the selectivity of the reaction and formation of a particular N,N?-2,5-DKP can be switched. The cyclization works in the presence of a variety of protection groups and diverse functionalities. The teachings herein provide techniques for synthesizing N,N?-2,5-DKPs that can be readily docked with drug candidates for shuttling across the blood brain barrier. This method provides a facile way to produce substituted DKPs containing groups ready for post-modification to include docking drug candidates.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: August 10, 2021
    Assignee: Triad National Security, LLC
    Inventors: Robert F. Williams, Paul William Peterson, Robert David Gilbertson, Jurgen G. Schmidt, Charlie E. Strauss
  • CONTROLLED CYCLIZATION OF PEPTOIDS TO FORM CHIRAL DIKETOPIPERAZINES
    Publication number: 20200131140
    Abstract: The present disclosure provides improved methods for controlled cyclization of peptoid dimers to form N,N?-2,5-diketopiperazines (N,N?-2,5-DKPs) with significant selectivity. In at least some examples, selectivity is based on a serendipitous conglomeration of slow exchange of amide rotamers, steric repulsion from the degree of ?-substitution, and the geometric bulk of an amine nucleophile. By varying reaction conditions, the selectivity of the reaction and formation of a particular N,N?-2,5-DKP can be switched. The cyclization works in the presence of a variety of protection groups and diverse functionalities. The teachings herein provide techniques for synthesizing N,N?-2,5-DKPs that can be readily docked with drug candidates for shuttling across the blood brain barrier. This method provides a facile way to produce substituted DKPs containing groups ready for post-modification to include docking drug candidates.
    Type: Application
    Filed: October 30, 2019
    Publication date: April 30, 2020
    Applicant: Triad National Security, LLC
    Inventors: Robert F. Williams, Paul William Peterson, Robert David Gilbertson, Jurgen G. Schmidt, Charlie E. Strauss