Abstract: Systems for managing workflows to perform chemical or biological reactions using microfluidic devices.

Abstract: A gasification reactor includes a wiper system including at least one wiper blade operable to wipe an interior surface of the reactor. A condenser unit of the gasification reactor includes a scraper system including at least one scraper segment operable to scrape an interior surface of the condenser unit.

Abstract: An SBS-formatted microfluidic device where the geometry of the plate defines an array of interrogation areas, and where each interrogation area encompasses at least one reaction site.

Abstract: The present invention provides compositions and methods for reducing steric hindrance in the product of nucleic acid polymerase reaction. Methods and compositions of the invention encompass application of exonucleases, endonucleases, and uracil-DNA glycosylases to a nucleic acid polymerase reaction such that newly formed nucleic acid strands are modified (e.g., cleaved) while the polymerase reaction continues to proceed.

Abstract: New microfluidic devices, useful for carrying out chemical reactions, are provided. The devices are adapted for on-chip solvent exchange, chemical processes requiring multiple chemical reactions, and rapid concentration of reagents.

Abstract: The invention provides compounds of the formula (I); or salts or solvates or N-oxides thereof; wherein: Rq is selected from groups (a), (b) and (c); the asterisk denoting the point of attachment to the pyrazole ring; X is N or CR5; X? is NR4; O, S or S(O); A is a bond or —(CH2)m—(B)n—; B is C?O, NRg(C?O) or O(C?O) wherein Rg is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; m is 0, 1 or 2; n is 0 or 1; R0 is hydrogen or, together with NRg when present, forms a group —(CH2)p— wherein p is 2 to 4; and R1 to R6b are as defined in the description. Compounds of the formula (I) have activity as inhibitors of CDK, aurora and GSK-3 kinases are useful in treating or preventing diseases such as cancers that are mediated by the said kinases.

Abstract: An apparatus includes: a spatial differential value calculation unit that calculates a primary spatial differential value and a secondary spatial differential value of a brightness value with respect to each of a plurality of directions in each pixel of the image; a maximum and minimum direction estimation unit that estimates a maximum direction and a minimum direction for each pixel, the maximum direction being a direction with which the primary spatial differential value is a maximum value, the minimum direction being a direction with which the primary spatial differential value is a minimum value; and an evaluated value calculation unit that calculates a first evaluated value of each pixel using the primary spatial differential value in the maximum direction, the primary spatial differential value in the minimum direction, and the secondary spatial differential value in the maximum direction.

Abstract: The invention provides compounds of the formula (1): The compounds have activity against cyclin depdenent kinases, glycogen synthase kinase and Auroa kinases and are therefore useful to treat cancer and viral diseases.

Abstract: An image processor, method, and program are provided for detecting edges in an image. In one embodiment, an image processor detects edges from an image while suppressing the effects of noise. Brightness gradient values of each pixel of the image are found for each of a plurality of directions. An amount of noise in the image is estimated based on the brightness gradient values and edge intensities are normalized in order to suppress the effects of the noise.

Abstract: The invention provides compounds of the formula (I): The compounds have activity against cyclin dependent kinases, glycogen synthase kinase and Auroa kinases and are therefore useful to treat cancer and viral diseases.

Abstract: Systems for managing workflows to perform chemical or biological reactions using microfluidic devices.

Abstract: The invention provides compounds of the formula (0) or salts or tautomers or N-oxides or solvates thereof for use in the prophylaxis or treatment of disease states and conditions such as cancers mediated by cyclin-dependent kinase and glycogen synthase kinase-3. In formula (0): X is a group R1-A-NR4— or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C?O, NRg(C?O) or O(C?O) wherein Rg is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from halogen (e.g.

Abstract: A method for identifying a ligand of a target macromolecule is disclosed, comprising the steps of: soaking one or more crystals of the target macromolecule in a solution containing a collection of compounds generated in situ or separate from the crystal, where the solution has been prepared without the purification of the synthesized collection of compounds; obtaining an X-ray crystal diffraction pattern of the soaked macromolecule crystal; and using said X-ray crystal diffraction pattern to identify any compound bound to the macromolecule crystal, said compound being a ligand of the target macromolecule.

Abstract: The invention provides a compound of the formula (I): wherein E is O, S, or NH; G is selected from hydrogen; carbocyclic and heterocyclic groups having from 3 to 12 ring members; and acyclic C1-8 hydrocarbyl groups optionally substituted; provided that E—G is not OH or SH and further provided that E—G does not contain the group O—O; two adjacent moieties selected from R3, R4, R5 and R6, together with the carbon atoms to which they are attached, form a fused heterocyclic group having from 5 to 7 ring members and 1, 2 or 3 ring heteroatoms selected from N, O and S; and the other two moieties selected from R3, R4, R5 and R6 are the same or different and are each as defined in the description. The Invention also provides compounds of the formula (I) for use as inhibitors of cyclin dependent kinases and for use in the treatment of disease states and conditions mediated by cyclin dependent kinases.

Abstract: The invention provides a compound of the formula (I) for use in the prophylaxis or treatment of a disease state or condition mediated by a cyclin dependent kinase: wherein A is a group R2 or CH2—R2 where R2 is a carbocyclic or heterocyclic group having from 3 to 12 ring members; B is a bond or an acyclic linker group having a linking chain length of up to 3 atoms selected from C, N, S and O; R1 is hydrogen or a group selected from SO2Rb, SO2NR7R8, CONR7R8, NR7R9 and carbocyclic and heterocyclic groups having from 3 to 7 ring members; R3, R4, R5 and R6 are the same or different and are each selected from hydrogen, halogen, hydroxy, trifluoromethyl, cyano, nitro, carboxy, amino, carbocyclic and heterocyclic groups having from 3 to 12 ring members; a group Ra—Rb wherein Ra is a bond, O, CO, X1C(X2), C(X2)X1, X1C(X2)X1, S, SO, SO2, NRc, SO2NRc or NRcSO2; and Rb is selected from hydrogen, carbocyclic and heterocyclic groups having from 3 to 12 ring members, and a C1-8 hydrocarbyl group optionally substitu

Abstract: A method of treating or preventing diseases or conditions mediated through the action of oxytocin which comprises administering to a mammal in need thereof of an effective amount of a compound of the formula (I) and/or a physiologically acceptable derivative thereof, wherein the substituents have the meaning given in the description. Disclosed are also novel compounds of formula (I) and processes for their preparation.

Abstract: An apparatus for cutting hay, straw, or other agricultural materials is provided with an intake hopper which directs a supply of material to be cut into a holding chamber. The material in the holding chamber is separated from the material remaining in the intake hopper by a pair of separating blades, while an advancement plate pushes the material in the holding chamber toward a cutting grid. A sliding panel is pulled behind the advancement plate to prevent the material remaining in the intake hopper from falling behind the advancement plate. The material in the holding chamber is cut into shorter lengths as it is pressed through horizontal and vertical slicing blades of the cutting grid.

Abstract: An alignment maintenance device has one or two guide members mounted on the roller of a conveyor system to counteract any tendency of a conveyor belt to move laterally. The guide member has a split sleeve including a cylindrical hub and radial flanges. The flanges are bolted together to clamp the sleeve tightly on the roller adjacent the conveyor belt. A dome-shaped disc is fixed to the inside edge of the sleeve, placing it between the sleeve and conveyor belt. The disc prevents the belt from moving laterally on the roller.