Abstract: A system for producing, from data affiliated with images of a location, a digital map can include a processor and a memory. The memory can store a productions module and a communications module. The production module can include instructions that cause the processor to produce, from the data affiliated with the images of the location, the digital map. The data, for an image, can exclude pixel color data, but can include information about: (1) a pose of a camera that produced the image and (2) one or more of a position of a point on: (a) a lane boundary of a lane of a road in the image, (b) a road boundary of the road, or (c) a landmark in the image. The communications module can include instructions that cause the processor to transmit the digital map to a vehicle to be used to control a movement of the vehicle.

Abstract: The present disclosure is directed to compounds of formula (I): wherein X, Y, R1, R2 and R3 are as described herein, as stereoisomers, enantiomers or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, and pharmaceutical compositions comprising the compounds of formula (I), as described herein, which are useful as voltage-gated sodium channel modulators and are therefore are useful in treating seizure disorders such as epilepsy.

Abstract: Antigen binding proteins that interact with ASGR, ASGR-1 and/or ASGR-2 are described as well as methods of making and using such antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of ASGR, ASGR-1 and/or ASGR-2 antigen binding proteins. Methods of treating and preventing cardiovascular disease by administering a pharmaceutically effective amount of interfering RNA compositions that reduce expression of ASGR, ASGR-1 and/or ASGR-2 are described.

Abstract: The present invention relates to a method for obtaining a bioactive serum fraction derived from fresh rose flowers (Rosa spp.). The present invention also provides bioactive serum fractions and bioactive extracts derived from fresh rose flowers (Rosa spp.) and compositions comprising the same. The present invention further relates to a method of cosmetic treatment for improving skin appearance associated with antioxidant and antiaging properties of the bioactive serum fraction and the bioactive extract derived from fresh rose flowers (Rosa spp.).

Abstract: The present disclosure relates to topical treatment of skin diseases, such as psoriasis, atopic dermatitis, alopecia, vitiligo, Reiter's syndrome, pityriasis rubra pilaris, epidermolysis bullosa simplex, palmoplantar keratoderma, pachyonychia congenita, steatocystoma multiplex, cutaneous lichen planus, cutaneous T-cell lymphoma, hidradenitis suppurativa, contact dermatitis, ichthyosis, and a disorder of keratinization, using (a) a JAK inhibitor, or a pharmaceutically acceptable salt thereof, and (b) vitamin D3, a vitamin D3 analog, or a pharmaceutically acceptable salt thereof.

Abstract: Provided are anti-ABCB 1 antibodies that may be used as multi-specific, including bispecific, antibodies targeting both ABCB 1 and a tumor-associated antigen (TAA), as well as pharmaceutical compositions, nucleic acids, recombinant expression vectors, cells, and kits that include or encode such antibodies and multi-specific antibodies. Further included are uses and methods of treating conditions where inhibition of ABCB 1-mediated efflux transport is desirable, such as, cancer or multi-drug resistance mediated by the ABCB1 transporter, e.g., multi-drug resistant cancer. In particular, the disclosure provides humanized multi-specific, e.g. bispecific, IgG (IgG1) antibodies that bind ABCB1 and a TAA. Multi-specific IgG1 antibody molecules are provided with Fc substitutions in at least one of a first and a second heavy chain constant region.

Abstract: In one embodiment, a system comprises: a processor to execute a native operating system (OS); and an interface circuit coupled to the processor, the interface circuit configured to tunnel communications of a plurality of tunneled protocols, the interface circuit to couple to at least one device via a first tunneled protocol, where a connection manager for the interface circuit is to execute in a user space of the native OS. Other embodiments are described and claimed.

Abstract: Exemplary embodiments of a composite pallet with augmented compression support may comprise a pallet pulp body, a multiplicity of support foot sheathes, and a support bottom plate. The pallet pulp body may be comprised of pulp and may have an upper faceplate and a plurality of support feet disposed oppositely of the upper faceplate. A foot cavity may be defined within each support foot. Each of the support foot sheaths may envelope at least a portion of a corresponding support foot. The support bottom plate may be affixed to two or more of the support foot sheaths. A plurality of arcuate stiffener grooves may be disposed in the upper faceplate. One or more of the foot cavities may have a compression column disposed therein. Each compression column may comprise one or more column layers, a compression column block, or a combination thereof. The column layers may be nested.

Abstract: A method for detecting collisions associated with a simulation includes generating a plurality of dual quaternion representations associated with a plurality of curved trajectories for a plurality of objects. The method also includes determining a semialgebraic domain associated with the plurality of dual quaternion representations and performing an optimization over the semialgebraic domain to determine one or more collision states associated with the plurality of objects. The method further includes causing the simulation to be performed based on the one or more collision states.

Abstract: Disclosed herein is an input device having adjustable input mechanisms. The input mechanisms of the input device may be dynamically adjusted based on one or more input characteristics associated with a user. Accordingly, the input device may be customized to fit a user's input preferences.

Abstract: The present disclosure relates to a powered screwdriver. The powered screwdriver includes a housing, a motor housed in the housing and a tool holder driven by the motor. The tool holder selectively holds both a screwdriver bit and a hex key. The hex key includes a bend such that legs of the hex key are transverse to one another.

Abstract: An electronic device able to communicate using both a long-range and a short-range wireless communication technology. A transceiver of the electronic device switches its operation mode based on a power saving mode of the long-range wireless communication technology. In particular, the electronic device switches between a short-range mode and a long-range mode based on the power saving mode of the long-range communication technology.

Abstract: A method for detecting collisions associated with a simulation includes generating a plurality of spline-based representations associated with a plurality of objects. The method also includes determining a semialgebraic domain associated with the plurality of spline-based representations and performing an optimization over the semialgebraic domain to determine one or more collision states associated with the plurality of objects. The method further includes causing the simulation to be performed based on the one or more collision states.

Abstract: A method for disrupting a blood clot with ultrasound and at least one cavitation enhancing agent includes administering at least one cavitation enhancing agent into a blood vessel of a subject. The method further includes monitoring the at least one cavitation enhancing agent to determine when at least a portion of the at least one cavitation enhancing agent has reached a blood clot. The method further includes controlling application of ultrasound energy to the at least one cavitation enhancing agent within the blood vessel of the subject such that, during a first time period, cavitation-enhancing ultrasound energy is not applied to the at least one cavitation enhancing agent within the blood vessel and, during a second time period after the first time period, cavitation enhancing ultrasound energy is applied to the at least one cavitation enhancing agent within the blood vessel.

Abstract: Exemplary embodiments of a composite pallet with augmented compression support may comprise a pallet pulp body, a multiplicity of support foot sheathes, and a support bottom plate. The pallet pulp body may be comprised of pulp and may have an upper faceplate and a plurality of support feet disposed oppositely of the upper faceplate. A foot cavity may be defined within each support foot. Each of the support foot sheaths may envelope at least a portion of a corresponding support foot. The support bottom plate may be affixed to two or more of the support foot sheaths. A plurality of arcuate stiffener grooves may be disposed in the upper faceplate. One or more of the foot cavities may have a compression column disposed therein. Each compression column may comprise one or more column layers, a compression column block, or a combination thereof. The column layers may be nested.

Abstract: The disclosed embodiments disclose techniques for accessing a scale-out block interface in a cloud-based distributed computing environment (CBDCE). During operation, an instance of a block device service (BDS) receives a data request from a client. The BDS instance translates the data request into a set of data block accesses, and then sends the translated data request to a data processing layer service (DPL). The DPL instance services the data request using a set of data operations that leverage one or more of a distributed cache, a distributed database, and a cloud storage system. The BDS service leverages the DPL instance to provide to the client an abstraction of a highly-available block storage device with unlimited storage space via the scale-out block interface.

Abstract: Embodiments of the present disclosure are directed to systems, methods, and computer product programs to identify one or more seminal cases within a database containing legal case data. The disclosed systems and methods provide an approach to identify one or more seminal cases for particular legal issues by mining a text database containing electronic legal documents for the reasons for citing and mining the text within to determine whether the legal issue addressed in the reasons for citing is directed to a seminal case. The data is created through data mining and obtained from the plurality the reasons for citing identifying the seminal cases for a particular legal issue such that the output data corresponding to the seminal cases causes an external device to distinguish the seminal cases when one or more of the seminal cases are returned as the result of a search.

Abstract: The disclosed embodiments disclose techniques for journaling data received in a cloud-based distributed computing environment (CBDCE). Multiple services simultaneously execute on the CBDCE compute nodes, with each service comprising multiple service instances that simultaneously execute on multiple, distinct compute nodes of the CBDCE. The CBDCE includes a distributed database that enables coordination between the service instances of services that execute in the CBDCE; this distributed database also includes multiple distributed database instances that simultaneously executing on multiple different CBDCE compute nodes. During operation, a service instance executing on one of these compute nodes receives a client request. The service instance submits this client request to a distributed database instance and, in parallel, also submits the client request and its associated user data to a distributed journaling service.

Abstract: A cooking appliance includes a cooktop having a cooking zone with at least one heating element beneath the cooktop in the cooking zone, a temperature sensor that detects the temperature of the cooking zone, and a controller. The controller executes a temperature-protect mode upon receiving an indication of a presence of a temperature-sensitive component on the surface of the cooktop by adjusting power supplied to the heating element in response to a detected temperature of the cooking zone approaching, meeting or exceeding a threshold temperature in order to ensure that the detected temperature does not exceed the threshold temperature beyond a predetermined degree and/or for a predetermined period of time. The threshold temperature is predetermined to be one that will not damage the temperature-sensitive component.

Abstract: The disclosed embodiments disclose techniques for managing a distributed cache in a cloud-based distributed computing environment (CBDCE). During operation, an instance of a data processing layer service (DPL) receives a data request from a client that specifies an address and an operation for a target data block. The DPL instance uses these to determine a first cache instance of the distributed cache that is assigned to cache a metadata entry that links the address with a data block fingerprint for the target data block. The DPL instance then uses the data block fingerprint and the cache mapping to determine a second cache instance that is assigned to store the target data block, and then accesses the second cache instance to complete the operation for the target data block.