Patents by Inventor Paula A. Faria-Waziry

Paula A. Faria-Waziry has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulating oncolytic vesicular stomatitis virus (VSV) with statins for cancer treatment
    Patent number: 9289456
    Abstract: In the instant invention, simvastatin (Sim) is used to modulate Vesicular Stomatitis Virus (VSV) infection at the level of viral replication for treatment of cancer. Both lipid-lowering and pleiotropic cellular effects of simvastatin are exploited in this modulation. Simvastatin upregulates the expression of Rae1 and Nup98, therefore altering normal cellular mRNA distribution and reverting VSV's mRNA export block. Furthermore, simvastatin causes redistribution of Flotillin-1, which affects VSV replication/budding. Simvastatin is further used as a neoadjuvant for the selective modulatory control of live VSV oncolytic therapy.
    Type: Grant
    Filed: November 22, 2011
    Date of Patent: March 22, 2016
    Assignee: Nova Southeastern University
    Inventors: Paula A. Faria-Waziry, Luigi X. Cubeddu, Ana Maria Castejon
  • MODULATING ONCOLYTIC VSV AND UPREGULATING RAE1 AND NUP98 WITH STATINS
    Publication number: 20130302284
    Abstract: Simvastatin is used to modulate VSV infection at the level of viral replication. Both lipid-lowering and pleiotropic cellular effects of simvastatin are exploited in the modulation. Simvastatin upregulates the expression of Rae1 and Nup98, therefore altering normal cellular mRNA distribution and reverting VSV's mRNA export block. Furthermore, simvastatin causes redistribution of Flotillin-1, which affects VSV replication/budding. Simvastatin is further used as a neoadjuvant for the selective modulatory control of live VSV oncolytic therapy.
    Type: Application
    Filed: November 22, 2011
    Publication date: November 14, 2013
    Applicant: NOVA SOUTHEASTERN UNIVERSITY
    Inventors: Paula A. Faria-Waziry, Luigi X. Cubeddu, Ana Maria Castejon