Patents by Inventor Paula Ann Borden

Paula Ann Borden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for measuring stromelysin-1 promoter activity
    Patent number: 6338944
    Abstract: This invention relates to a human stromelysin-1 (i.e., HSL-1) promoter and uses therefor. In particular, the invention provides a purified DNA containing a functional HSL-1 promoter region that corresponds in structure to the native genomic form of this promoter, an expression vector containing a portion of the purified promoter DNA operatively linked to a heterologous DNA sequence encoding a detectable gene product, a host cell transformed with this factor, a pharmacologic screening assay for stromelysin-1 promoter modulating activity, and a method-of modulating TNF &agr; level and matrix metalloproteinase activities in inflamed tissues of a mammal.
    Type: Grant
    Filed: April 14, 2000
    Date of Patent: January 15, 2002
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Paula Ann Borden, Renu Anand Heller
  • Human stromelysin-1 promoter
    Patent number: 5824794
    Abstract: This invention relates to a human stromelysin-1 (i.e., HSL-1) promoter and uses therefor. In particular, the invention provides a purified DNA containing a functional HSL-1 promoter region that corresponds in structure to the native genomic form of this promoter, an expression vector containing a portion of the purified promoter DNA operatively linked to a heterologous DNA sequence encoding a detectable gene product, a host cell transformed with this factor , a pharmacologic screening assay for stromelysin-1 promoter modulating activity, and a method of modulating TNF .alpha. level and matrix metalloproteinase activities in inflamed tissues of a mammal.
    Type: Grant
    Filed: December 23, 1994
    Date of Patent: October 20, 1998
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Paula Ann Borden, Renu Anand Heller