Abstract: A deflector (38) including: a support (70); an intermediate member (72), pivotally mounted in the support (70) around a first rotation axis (B-B?); at least a secondary pivoting member (74), pivotally connected to the intermediate member (72) around a second rotation axis (C-C?) parallel to the first rotation axis (B-B?); for each secondary pivoting member (74), at least a pair of rotating members (76). Each rotating member (76) is connected to the secondary pivoting member (74). The deflector (38) including: a guiding mechanism, for guiding each rotating member (76) in translation with regard to the support (70) along a translation axis (D-D?) non parallel to the first rotation axis (B-B?); a connecting member (78), pivotally mounted to the secondary pivoting member (74). The rotating member (76) is rotatably mounted on the connecting member (78) around a rotating member rotation axis (E-E?).

Abstract: The use of HspBP1 protein or part thereof for the preparation of an anti-tumor pharmaceutical composition, and its optional combination with one or more chemotherapeutic agents. A gene construct for the expression of said protein; a production process; a process of evaluation of tumor cells; and a method of sensitization of tumors to chemotherapeutic agents. A new experimental model in vivo and in vitro for the development/evaluation of anti-tumor agents. The pharmaceutical compositions provide anti-tumor action and have high specificity to neoplastic cells, resulting in less cytotoxicity to normal dividing cells, in part as a solution to the drawbacks of currently known chemotherapy therapeutic regimens.

Abstract: A deflector (38) including: a support (70); an intermediate member (72), pivotally mounted in the support (70) around a first rotation axis (B-B?); at least a secondary pivoting member (74), pivotally connected to the intermediate member (72) around a second rotation axis (C-C?) parallel to the first rotation axis (B-B?); for each secondary pivoting member (74), at least a pair of rotating members (76). Each rotating member (76) is connected to the secondary pivoting member (74). The deflector (38) including: a guiding mechanism, for guiding each rotating member (76) in translation with regard to the support (70) along a translation axis (D-D?) non parallel to the first rotation axis (B-B?); a connecting member (78), pivotally mounted to the secondary pivoting member (74). The rotating member (76) is rotatably mounted on the connecting member (78) around a rotating member rotation axis (E-E?).

Abstract: The use of HspBP1 protein or part thereof for the preparation of an anti-tumor pharmaceutical composition, and its optional combination with one or more chemotherapeutic agents. A gene construct for the expression of said protein; a production process; a process of evaluation of tumor cells; and a method of sensitization of tumors to chemotherapeutic agents. A new experimental model in vivo and in vitro for the development/evaluation of anti-tumor agents. The pharmaceutical compositions provide anti-tumor action and have high specificity to neoplastic cells, resulting in less cytotoxicity to normal dividing cells, in part as a solution to the drawbacks of currently known chemotherapy therapeutic regimens.