Patents by Inventor Paula Francom

Paula Francom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclic nucleosides and nucleotides as therapeutic agents
    Patent number: 8802840
    Abstract: The invention relates to the use of bicyclic nucleosides and nucleotides based on formula (II) for the treatment of infectious diseases, and in particular, viral infections.
    Type: Grant
    Filed: March 8, 2006
    Date of Patent: August 12, 2014
    Assignee: Biota Scientific Management Pty Ltd.
    Inventors: Paula Francom, Roland Henry Nearn, Alistair George Draffan, John Nicholas Lambert, Silas Bond
  • Bicyclic nucleosides and nucleotides as therapeutic agents
    Patent number: 8501699
    Abstract: The present disclosure relates to the use and methods of manufacture of bicyclic nucleosides and nucleotides for the treatment and prevention of infectious and proliferative diseases, including microbial infections and cancer.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: August 6, 2013
    Assignee: Biota Scientific Management Pty Ltd
    Inventors: Paula Francom, Barbara Frey, Silas Bond, Alistair George Draffan, Michael Harding, Richard Hufton, Saba Hangiri, Michael John Lilly, Edward Tyndall, Jianmin Duan, Richard Bethell, George Kukolj
  • Method for the preparation of 2-halo-2?-deoxyadenosine compounds from 2?-deoxyguanosine
    Patent number: 8466275
    Abstract: The present invention is a method for preparing 2-halo-6-aminopurines, and more specifically for preparing the clinical agent cladribine (2-chloro-2?-deoxyadenosine, CldAdo, 4), a drug of choice against hairy-cell leukemia and other neoplasms, from 2-amino-6-oxopurines, which are readily obtained from the naturally occurring compound 2?-deoxyguanosine. According to the methods of the present invention, the 6-oxo group of a protected 2?-deoxyguanosine (1) is converted to a 6-(substituted oxy) leaving group, or alternatively to a 6-chloro leaving group, the 2-amino group is replaced with a 2-chloro group, the 6-(substituted oxy) leaving group, or alternatively the 6-chloro leaving group, is replaced with a 6-amino group or, alternatively, a 2,6-dichloro substituted compound is selectively replaced with a 6-amino group, and the protecting groups are removed.
    Type: Grant
    Filed: July 2, 2009
    Date of Patent: June 18, 2013
    Assignee: Brigham Young University
    Inventors: Morris J. Robins, Zlatko Janeba, Paula Francom
  • Bicyclic nucleosides and nucleotides as therapeutic agents
    Patent number: 8415309
    Abstract: The present disclosure relates to the use and methods of manufacture of bicyclic nucleosides and nucleotides for the treatment and prevention of infectious and proliferative diseases, including microbial infections and cancer.
    Type: Grant
    Filed: January 11, 2012
    Date of Patent: April 9, 2013
    Assignee: Biota Scientific Managment Pty Ltd
    Inventors: Paula Francom, Barbara Frey, Jianmin Duan, Richard Bethell, George Kukolj
  • BICYCLIC NUCLEOSIDES AND NUCLEOTIDES AS THERAPEUTIC AGENTS
    Publication number: 20130018013
    Abstract: The present disclosure relates to the use and methods of manufacture of bicyclic nucleosides and nucleotides for the treatment and prevention of infectious and proliferative diseases, including microbial infections and cancer.
    Type: Application
    Filed: September 7, 2012
    Publication date: January 17, 2013
    Applicant: BIOTA SCIENTIFIC MANAGEMENT PTY LTD
    Inventors: Paula Francom, Barbara Frey, Silas Bond, Alistair George Draffan, Michael Harding, Richard Hufton, Saba Jahangiri, Michael John Lilly, Edward Tyndall, Jianmin Duan, Richard Bethell, George Kukolj
  • BICYCLIC NUCLEOSIDES AND NUCLEOTIDES AS THERAPEUTIC AGENTS
    Publication number: 20120122811
    Abstract: The present disclosure relates to the use and methods of manufacture of bicyclic nucleosides and nucleotides for the treatment and prevention of infectious and proliferative diseases, including microbial infections and cancer.
    Type: Application
    Filed: January 11, 2012
    Publication date: May 17, 2012
    Applicant: Biota Scientific Management Pty Ltd
    Inventors: Paula Francom, Barbara Frey, Silas Bond, Jianmin Duan, Richard Bethell, George Kukolj
  • Bicyclic nucleosides and nucleotides as therapeutic agents
    Patent number: 8119607
    Abstract: The present disclosure relates to the use and methods of manufacture of bicyclic nucleosides and nucleotides for the treatment and prevention of infectious and proliferative diseases, including microbial infections and cancer.
    Type: Grant
    Filed: July 1, 2009
    Date of Patent: February 21, 2012
    Assignee: Biota Scientific Management Pty Ltd
    Inventors: Paula Francom, Barbara Frey, Silas Bond, Alistair George Draffan, Michael Harding, Richard Hufton, Saba Jahangiri, Michael John Lilly, Edward Tyndall, Jianmin Duan, Richard Bethell, George Kukolj
  • Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates
    Patent number: 7994143
    Abstract: The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like.
    Type: Grant
    Filed: June 9, 2010
    Date of Patent: August 9, 2011
    Assignees: Chimerix, Inc., The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle, Jacqueline Ruiz, Merrick R. Almond, George R. Painter, Timothy A. Riley, Paula Francom
  • BICYCLIC NUCLEOSIDES AND NUCLEOTIDES AS THERAPEUTIC AGENTS
    Publication number: 20100291031
    Abstract: The invention relates to the use of bicyclic nucleosides and nucleotides based on formula (II) for the treatment of infectious diseases, and in particular, viral infections.
    Type: Application
    Filed: March 8, 2006
    Publication date: November 18, 2010
    Applicant: Biota Scientific Management Pty Ltd
    Inventors: Paula Francom, Roland Nearn, Alistair Draffan, John Lambert, Silas Bond
  • Metabolically Stable Alkoxyalkyl Esters of Antiviral or Antiproliferative Phosphonates, Nucleoside Phosphonates and Nucleoside Phosphates
    Publication number: 20100249056
    Abstract: The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like.
    Type: Application
    Filed: June 9, 2010
    Publication date: September 30, 2010
    Applicants: CHIMERIX, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Karl Y. Hostetler, James R. Beadle, Jacqueline Ruiz, Merrick R. Almond, George R. Painter, Tim Riley, Paula Francom
  • Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates
    Patent number: 7749983
    Abstract: The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like.
    Type: Grant
    Filed: April 18, 2007
    Date of Patent: July 6, 2010
    Assignees: Chimerix, Inc., The Regents of the University of California
    Inventors: Karl Y. Hostetler, James R. Beadle, Jacqueline Ruiz, Merrick R. Almond, George R. Painter, Timothy A. Riley, Paula Francom
  • BICYCLIC NUCLEOSIDES AND NUCLEOTIDES AS THERAPEUTIC AGENTS
    Publication number: 20100035836
    Abstract: The present disclosure relates to the use and methods of manufacture of bicyclic nucleosides and nucleotides for the treatment and prevention of infectious and proliferative diseases, including microbial infections and cancer.
    Type: Application
    Filed: July 1, 2009
    Publication date: February 11, 2010
    Inventors: Paula Francom, Barbara Frey, Silas Bond, Alistair George Draffan, Michael Harding, Richard Hufton, Saba Jahangiri, Michael John Lilly, Edward Tyndall, Jianmin Duan, Richard Bethell, George Kukolj
  • METHOD FOR THE PREPARATION OF 2-HALO-2'-DEOXYADENOSINE COMPOUNDS FROM 2'-DEOXYGUANOSINE
    Publication number: 20090270604
    Abstract: The present invention is a method for preparing 2-halo-6-aminopurines, and more specifically for preparing the clinical agent cladribine (2-chloro-2?-deoxyadenosine, CldAdo, 4), a drug of choice against hairy-cell leukemia and other neoplasms, from 2-amino-6-oxopurines, which are readily obtained from the naturally occurring compound 2?-deoxyguanosine. According to the methods of the present invention, the 6-oxo group of a protected 2?-deoxyguanosine (1) is converted to a 6-(substituted oxy) leaving group, or alternatively to a 6-chloro leaving group, the 2-amino group is replaced with a 2-chloro group, the 6-(substituted oxy) leaving group, or alternatively the 6-chloro leaving group, is replaced with a 6-amino group or, alternatively, a 2,6-dichloro substituted compound is selectively replaced with a 6-amino group, and the protecting groups are removed.
    Type: Application
    Filed: July 2, 2009
    Publication date: October 29, 2009
    Inventors: Morris J. Robins, Zlatko Janeba, Paula Francom
  • Method for the preparation of 2-halo-2?-deoxyadenosine compounds from 2?-deoxyguanosine
    Patent number: 7572909
    Abstract: The present invention is a method for preparing 2-halo-6-aminopurines, and more specifically for preparing the clinical agent cladribine (2-chloro-2?-deoxyadenosine, CldAdo, 4), a drug of choice against hairy-cell leukemia and other neoplasms, from 2-amino-6-oxopurines, which are readily obtained from the naturally occurring compound 2?-deoxyguanosine. According to the methods of the present invention, the 6-oxo group of a protected 2?-deoxyguanosine (1) is converted to a 6-(substituted oxy) leaving group, or alternatively to a 6-chloro leaving group, the 2-amino group is replaced with a 2-chloro group, the 6-(substituted oxy) leaving group, or alternatively the 6-chloro leaving group, is replaced with a 6-amino group or, alternatively, a 2,6-dichloro substituted compound is selectively replaced with a 6-amino group, and the protecting groups are removed.
    Type: Grant
    Filed: September 25, 2003
    Date of Patent: August 11, 2009
    Assignee: Brigham Young University
    Inventors: Morris J. Robins, Zlatko Janeba, Paula Francom
  • Bicyclic Nucleosides and Nucleotides as Therapeutic Agents
    Publication number: 20090004138
    Abstract: The invention relates to the use of bicyclic nucleosides and nucleotides based on formula (II) for the treatment of infectious diseases, and in particular, viral infections.
    Type: Application
    Filed: March 8, 2006
    Publication date: January 1, 2009
    Applicant: Biota Scientific Management Pty Ltd
    Inventors: Paula Francom, Roland Henry Nearn, Alistair George Draffan, John Nicholas Lambert, Silas Bond
  • Metabolically Stable Alkoxyalkyl Esters of Antiviral or Antiproliferative Phosphonates, Nucleoside Phosphonates and Nucleoside Phosphates
    Publication number: 20080009462
    Abstract: The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like.
    Type: Application
    Filed: April 18, 2007
    Publication date: January 10, 2008
    Applicants: CHIMERIX, INC., UNIVERSITY OF CALIFORNIA, SAN DIEGO
    Inventors: Karl Hostetler, James Beadle, Jacqueline Ruiz, Merrick Almond, George Painter, Tim Riley, Paula Francom
  • Method for the preparation of 2-halo-2'-deoxyadenosine compounds for 2'-deoxyguanosine
    Publication number: 20070032645
    Abstract: The present invention is a method for preparing 2-halo-6-aminopurines, and more specifically for preparing the clinical agent cladribine (2-chloro-2?-deoxyadenosine, CldAdo, 4), a drug of choice against hairy-cell leukemia and other neoplasms, from 2-amino-6-oxopurines, which are readily obtained from the naturally occurring compound 2?-deoxyguanosine. According to the methods of the present invention, the 6-oxo group of a protected 2?-deoxyguanosine (1) is converted to a 6-(substituted oxy) leaving group, or alternatively to a 6-chloro leaving group, the 2-amino group is replaced with a 2-chloro group, the 6-(substituted oxy) leaving group, or alternatively the 6-chloro leaving group, is replaced with a 6-amino group or, alternatively, a 2,6-dichloro substituted compound is selectively replaced with a 6-amino group, and the protecting groups are removed.
    Type: Application
    Filed: September 25, 2003
    Publication date: February 8, 2007
    Applicant: BRIGHAM YOUNG UNIVERSITY
    Inventors: Morris Robins, Zlatko Janeba, Paula Francom