Patents by Inventor Paula GUTIERREZ-MARTINEZ

Paula GUTIERREZ-MARTINEZ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance
    Patent number: 11891625
    Abstract: The methods and compositions described herein relate to producing, expanding, enriching, and/or maintaining hematopoietic stem cells ex vivo by treating the cells with an agent(s) that exhibits two or more activities selected from modulation of histone methylation; inhibition of TGF? signaling; inhibition of p38 signaling; activation of canonical Wnt signaling; and modulation of histone acetylation. In some embodiments, the technology described herein relates to transplantation of hematopoietic stem cells.
    Type: Grant
    Filed: April 21, 2020
    Date of Patent: February 6, 2024
    Inventors: Derrick J. Rossi, Wataru Ebina, Morag Stewart, Paula Gutierrez-Martinez, Lee L Rubin, Lance Davidow
  • Methods of in Vitro Cell Delivery
    Publication number: 20230183753
    Abstract: Compositions and methods for multiplex delivery and gene editing in vitro are provided.
    Type: Application
    Filed: October 27, 2022
    Publication date: June 15, 2023
    Applicant: Intellia Therapeutics, Inc.
    Inventors: Pooja Kyatsandra Narendra, Sean Michael Burns, Paula Gutierrez Martinez, Arti Mahendra Prakash Kanjolia, Anthony Monti, Aaron Prodeus, Mohamed Simo Arredouani, Özgün Kiliç, Reed Walker LaRiviere, Palak Sushil Sharma, Eleni Stampouloglou, Qingzhan Zhang
  • METHODS AND COMPOSITIONS RELATING TO HEMATOPOIETIC STEM CELL EXPANSION, ENRICHMENT, AND MAINTENANCE
    Publication number: 20200248143
    Abstract: The methods and compositions described herein relate to producing, expanding, enriching, and/or maintaining hematopoietic stem cells ex vivo by treating the cells with an agent(s) that exhibits two or more activities selected from modulation of histone methylation; inhibition of TGF? signaling; inhibition of p38 signaling; activation of canonical Wnt signaling; and modulation of histone acetylation. In some embodiments, the technology described herein relates to transplantation of hematopoietic stem cells.
    Type: Application
    Filed: April 21, 2020
    Publication date: August 6, 2020
    Applicants: CHILDREN'S MEDICAL CENTER CORPORATION, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Derrick J. ROSSI, Wataru EBINA, Morag STEWART, Paula GUTIERREZ-MARTINEZ, Lee L. RUBIN, Lance DAVIDOW
  • Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance
    Patent number: 10669528
    Abstract: The methods and compositions described herein relate to producing, expanding, enriching, and/or maintaining hematopoietic stem cells ex vivo by treating the cells with an agent(s) that exhibits two or more activities selected from modulation of histone methylation; inhibition of TGF? signaling; inhibition of p38 signaling; activation of canonical Wnt signaling; and modulation of histone acetylation. In some embodiments, the technology described herein relates to transplantation of hematopoietic stem cells.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: June 2, 2020
    Assignees: CHILDREN'S MEDICAL CENTER CORPORATION, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Derrick J. Rossi, Wataru Ebina, Morag Stewart, Paula Gutierrez-Martinez, Lee L. Rubin, Lance Davidow
  • METHODS AND COMPOSITIONS RELATING TO HOMOLOGY-DIRECTED REPAIR
    Publication number: 20200149038
    Abstract: The methods and compositions described herein relate to improvements in the efficiency and/or accuracy of targeted alterations to a nucleic acid sequence, e.g, gene editing technologies, by creating nick or DSB in a target nucleic in the presence of template molecule, an inhibitor of NHEJ and an agonist of HDR. In contrast to earlier technologies, these methods are not specific to each template and/or target sequence while retaining specificity of the editing itself.
    Type: Application
    Filed: March 28, 2017
    Publication date: May 14, 2020
    Applicant: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Derrick J. ROSSI, Bruna PAULSEN, Pankaj K. MANDAL, Wataru EBINA, Paula GUTIERREZ-MARTINEZ
  • METHODS AND COMPOSITIONS RELATING TO HEMATOPOIETIC STEM CELL EXPANSION, ENRICHMENT, AND MAINTENANCE
    Publication number: 20180187156
    Abstract: The methods and compositions described herein relate to producing, expanding, enriching, and/or maintaining hematopoietic stem cells ex vivo by treating the cells with an agent(s) that exhibits two or more activities selected from modulation of histone methylation; inhibition of TGF? signaling; inhibition of p38 signaling; activation of canonical Wnt signaling; and modulation of histone acetylation. In some embodiments, the technology described herein relates to transplantation of hematopoietic stem cells.
    Type: Application
    Filed: June 24, 2016
    Publication date: July 5, 2018
    Applicants: CHILDREN'S MEDICAL CENTER CORPORATION, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Derrick J. ROSSI, Wataru EBINA, Morag STEWART, Paula GUTIERREZ-MARTINEZ, Lee RUBIN, Lance DAVIDOW