Patents by Inventor Paula Hicks

Paula Hicks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200308617
    Abstract: Methods for recombinant production of steviol glycoside and compositions containing steviol glycosides are provided by this invention.
    Type: Application
    Filed: February 24, 2020
    Publication date: October 1, 2020
    Inventors: Michael Dalgaard Mikkelsen, Jorgen Hansen, Ernesto Simon, Federico Brianza, Angelika Semmler, Kim Olsson, Simon Carlsen, Louis Düring, Alexei Ouspenski, Paula Hicks
  • Publication number: 20200123583
    Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.
    Type: Application
    Filed: August 8, 2019
    Publication date: April 23, 2020
    Inventors: Jens Houghton-Larsen, Paula Hicks, Michael Naesby, Thomas Tange Ostergaard, Jorgen Hansen, Michael Mikkelsen Dalgaard, Esben Hansen Halkjaer, Ernesto Simon, Sabina Tavares
  • Patent number: 10612066
    Abstract: Methods for recombinant production of steviol glycoside and compositions containing steviol glycosides are provided by this invention.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: April 7, 2020
    Assignee: Evolva SA
    Inventors: Michael Dalgaard Mikkelsen, Jorgen Hansen, Ernesto Simon, Federico Brianza, Angelika Semmler, Kim Olsson, Simon Carlsen, Louis Düring, Alexei Ouspenski, Paula Hicks
  • Patent number: 10435730
    Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: October 8, 2019
    Assignee: EVOLVA SA
    Inventors: Jens Houghton-Larsen, Paula Hicks, Michael Naesby, Thomas Tange Ostergaard, Jorgen Hansen, Michael Mikkelsen Dalgaard, Esben Hansen Halkjaer, Ernesto Simon, Sabina De Andrade Periera Tavares
  • Publication number: 20190203243
    Abstract: Methods for recombinant production of steviol glycoside and compositions containing steviol glycosides are provided by this invention.
    Type: Application
    Filed: February 28, 2018
    Publication date: July 4, 2019
    Inventors: Michael Dalgaard Mikkelsen, Jorgen Hansen, Ernesto Simon, Federico Brianza, Angelika Semmler, Kim Olsson, Simon Carlsen, Louis Düring, Alexei Ouspenski, Paula Hicks
  • Patent number: 9957540
    Abstract: Methods for recombinant production of steviol glycoside and compositions containing steviol glycosides are provided herein.
    Type: Grant
    Filed: February 6, 2014
    Date of Patent: May 1, 2018
    Assignee: EVOLVA SA
    Inventors: Michael Dalgaard Mikkelsen, Jorgen Hansen, Ernesto Simon, Federico Brianza, Angelika Semmler, Kim Olsson, Simon Carlsen, Louis Düring, Alexei Ouspenski, Paula Hicks
  • Publication number: 20170321238
    Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.
    Type: Application
    Filed: February 22, 2017
    Publication date: November 9, 2017
    Inventors: Jens Houghton-Larsen, Paula Hicks, Michael Naesby, Thomas Tange Ostergaard, Jorgen Hansen, Michael Mikkelsen Dalgaard, Esben Halkjaer Hansen, Ernesto Simon, Sabina Tavares
  • Patent number: 9631215
    Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.
    Type: Grant
    Filed: August 8, 2012
    Date of Patent: April 25, 2017
    Assignee: EVOLVA SA
    Inventors: Jens Houghton-Larsen, Paula Hicks, Michael Naesby, Thomas Tange Ostergaard, Jorgen Hansen, Michael Mikkelsen Dalgaard, Esben Hansen Halkjaer, Ernesto Simon, Sabina De Andrade Periera Tavares
  • Publication number: 20160186225
    Abstract: Methods for recombinant production of steviol glycoside and compositions containing steviol glycosides are provided by this invention.
    Type: Application
    Filed: February 6, 2014
    Publication date: June 30, 2016
    Applicant: Evolva SA
    Inventors: Michael Dalgaard Mikkelsen, Jorgen Hansen, Ernesto Simon, Frederico Brianza, Angelika Semmler, Kim Olsson, Simon Carlsen, Louis Düring, Alexei Ouspenski, Paula Hicks
  • Publication number: 20150342234
    Abstract: Materials and methods for producing particular steviol glycosides, and high-purity compositions of particular steviol glycosides with improved sensory profilesare provided herein. The steviol glycosides can be, for example, rebaudioside D, rebaudioside A, and rebaudioside B, and can be produced by recombinant microorganisms.
    Type: Application
    Filed: December 4, 2013
    Publication date: December 3, 2015
    Inventors: Paula Hicks, Michael Mikkelsen, Jens Houghton-Larsen, Jorgen Hansen, Hans Peter Smits, Jens Mueller
  • Publication number: 20140329281
    Abstract: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.
    Type: Application
    Filed: August 8, 2012
    Publication date: November 6, 2014
    Inventors: Jens Houghton-Larsen, Paula Hicks, Michael Naesby, Thomas Tange Ostergaard, Jorgen Hansen, Michael Mikkelsen Dalgaard, Esben Hansen Halkjaer, Ernesto Simon, Sabina de Andrade Periera Tavares
  • Publication number: 20080020435
    Abstract: This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts.
    Type: Application
    Filed: March 7, 2007
    Publication date: January 24, 2008
    Applicant: Cargill, Incorporated
    Inventors: Ellen Burke, Steven Gort, Paula Hicks, Peter Luginbuhl, Sara McFarlan, Toby Richardson, Christopher Solheid, David Weiner, Lishan Zhao
  • Publication number: 20080020434
    Abstract: Monatin and certain stereoisomers of monatin, such as R,R monatin and S,R monatin, as well as salts thereof, are produced using polypeptides and biosynthetic pathways. These polypeptides and biosynthetic pathways are also useful in the production of R-2-hydroxy-2-(indoly-3-ylmethyl)-4-keto glutaric acid, an intermediate that is formed in certain monatin synthesis pathways, including some biosynthetic pathways.
    Type: Application
    Filed: March 6, 2007
    Publication date: January 24, 2008
    Applicant: Cargill, Incorporated
    Inventors: Brian Brazeau, Mervyn De Souza, Steven Gort, Paula Hicks, Sherry Kollmann, Jose Laplaza, Sara McFarlan, Fernando Sanchez-Riera, Christopher Solheid
  • Publication number: 20080015361
    Abstract: Methods and systems for increasing the production of equilibrium reactions are described. In some embodiments, a method comprises removing enzymes from a reaction mixture once equilibrium is achieved, selectively re-adding enzymes and reactants for driving the product-forming reaction to product, and optionally recycling stabilized intermediates, by-products and/or co-products back into the reaction mixture. In some embodiments, a method comprises purifying the desired product from a reaction mixture and selectively recycling one or more components of the reaction mixture, such as original reactants, intermediates, co-products or by-products back into the reaction mixture as desired to improve titer. Systems for implementing the methods are also provided. In some embodiments the methods and systems are implemented for increasing the production of monatin and monatin derivatives, produced in multi-step equilibrium pathways.
    Type: Application
    Filed: May 23, 2007
    Publication date: January 17, 2008
    Inventors: Anil Khare, Brent Hilbert, Christopher Solheid, Sara McFarlan, Fernando Sanchez-Riera, Kent Floy, Paula Hicks
  • Publication number: 20070105938
    Abstract: Products and methods for the in vivo production of monatin sweetener are provided. The products include microorganisms that are genetically modified to secrete or to improve secretion of monatin; microorganisms that are genetically modified to produce monatin; and microorganisms that are genetically modified to both secrete or improve secretion of monatin and produce monatin. The methods include producing monatin in such genetically engineered microorganisms.
    Type: Application
    Filed: April 20, 2006
    Publication date: May 10, 2007
    Applicant: Cargill, Incorporated
    Inventors: James Anderson, Mervyn DeSouza, Paula Hicks, Sherry Kollmann, Jose Laplaza
  • Publication number: 20070099277
    Abstract: Products and methods for the in vivo production of monatin sweetener are provided. The products include microorganisms that are genetically modified to secrete or to improve secretion of monatin; microorganisms that are genetically modified to produce monatin; and microorganisms that are genetically modified to both secrete or improve secretion of monatin and produce monatin. The methods include producing monatin in such genetically engineered microorganisms.
    Type: Application
    Filed: October 10, 2006
    Publication date: May 3, 2007
    Applicant: Cargill, Incorporated
    Inventors: James Anderson, Mervyn DeSouza, Paula Hicks, Sherry Kollmann
  • Publication number: 20060252135
    Abstract: Monatin and certain stereoisomers of monatin, such as R,R monatin and S,R monatin, as well as salts thereof, are produced using polypeptides and biosynthetic pathways. These polypeptides and biosynthetic pathways are also useful in the production of R-2-hydroxy-2-(indoly-3-ylmethyl)-4-keto glutaric acid, an intermediate that is formed in certain monatin synthesis pathways, including some biosynthetic pathways.
    Type: Application
    Filed: April 26, 2006
    Publication date: November 9, 2006
    Applicant: Cargill, Incorporated
    Inventors: Brian Brazeau, Ellen Burke, Mervyn DeSouza, Steven Gort, Paula Hicks, Sherry Kollmann, Peter Luginbuhl, Sara McFarlan, Toby Richardson, Fernando Sanchez-Riera, Christopher Solheid, David Weiner, Lishan Zhao
  • Publication number: 20060134742
    Abstract: A method is disclosed for increasing the specific activity of myo-inositol oxygenase. The method includes incubating a mixture including myo-inositol oxygenase and a non-sulfur containing reductant under conditions effective to increase the specific activity of the myo-inositol oxygenase. Also disclosed are methods for producing D-glucuronic acid and glucurono-?-lactone comprising incubating a mixture including myo-inositol, myo-inositol oxygenase, and oxygen under conditions effective to form 5 grams D-glucuronic acid per liter of the mixture to 400 grams D-glucuronic acid per liter of the mixture. Glucurono-?-lactone can be produced from the D-glucuronic acid product. Also disclosed are organisms and nucleic acids suitable for use in such methods.
    Type: Application
    Filed: December 17, 2004
    Publication date: June 22, 2006
    Inventors: Brian Brazeau, Jean-Claude De Troostembergh, Paula Hicks, Holly Jessen, Sara McFarlan, Willy Obyn, Fernando Sanchez-Riera, William Schroeder
  • Publication number: 20050282260
    Abstract: Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
    Type: Application
    Filed: April 26, 2005
    Publication date: December 22, 2005
    Inventors: Paula Hicks, Sara McFarlan
  • Publication number: 20050244937
    Abstract: Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for produding the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
    Type: Application
    Filed: November 3, 2004
    Publication date: November 3, 2005
    Inventors: Timothy Abraham, Douglas Cameron, Paula Hicks, Sara McFarlan, Jim Millis, John Rosazza, Lishan Zhao, David Weiner