Abstract: This invention is in the field of pharmaceutical agents and specifically relates to compounds, compositions, uses and methods for treating cancer, by combining VEGF(R) inhibitors and inhibitors of HGF/SF:c-Met.

Abstract: This invention is in the field of pharmaceutical agents and specifically relates to compounds, compositions, uses and methods for treating cancer, by—combining VEGF(R) inhibitors and inhibitors of HGF/SF:c-Met.

Abstract: A cabled lead comprising a first conductor cable having outer strands and a core strand is described. Each of the outer strands and core strand has outer wires that surround a core wire. The outer wires are made of a first material. The core wires have a tube, which may be in the form of a layer, and a core, and the core is disposed in the tube. The tube is made of the first material and the core is made of a second material. The first conductor cable is positioned in a first conductor sheath. The cabled lead has a second conductor cable which may be substantially structurally identical to the first conductor cable and is positioned in a second conductor sheath. The first and second conductor cables are helically coiled to form the cabled lead. In other embodiments, there may be one or more than two conductor cables.

Abstract: Devices, systems and methods for nerve stimulation for OSA therapy.

Abstract: An implantable lead has a lead body construction designed to accommodate loading forces exerted on the lead body during patient movement. The lead body may be sufficiently stretchable to resist forces that could otherwise cause lead failure, axial migration of the electrodes, anchor damage, or tissue damage. Increasing stretchability of a lead body can also increase the vulnerability of the lead body to flex fatigue, buckling fatigue, kinking, and crush. Therefore, the lead described herein includes conductors that comprise coiled wires positioned substantially parallel to a center axis of the lead. The conductors described herein may be coiled around fibers that limit the axial stiffness of the coiled wires to ensure full recovery from axial loading.