Patents by Inventor Paula Marie Ragan

Paula Marie Ragan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR TREATING IMMUNODEFICIENCY DISEASE
    Publication number: 20220257586
    Abstract: The present invention relates to methods of treating patients with WHIM syndrome or related disorders, such as myelokathexis, in which X4P-001 is administered in order to reduce the activity of CXCR4. The methods demonstrate surprising effectiveness, with comparatively little toxicity.
    Type: Application
    Filed: December 14, 2021
    Publication date: August 18, 2022
    Inventors: Robert D. Arbeit, Paula Marie Ragan
  • Methods for treating cancer
    Patent number: 11357742
    Abstract: The present invention relates to methods of treating patients with advanced forms of cancer, such as clear cell renal cell carcinoma, in which X4P-001 is administered in order to reduce angiogenic escape that typically occurs with TKI therapy. The methods demonstrate surprising results, including regression of tumor size and cell number, with comparatively little toxicity.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: June 14, 2022
    Assignees: X4 Pharmaceuticals, Inc., Georgetown University, Beth Israel Deaconess Medical Center, Inc.
    Inventors: Robert D. Arbeit, Paula Marie Ragan, Michael B. Atkins, James W. Mier, David McDermott
  • Methods for treating immunodeficiency disease
    Patent number: 11219621
    Abstract: The present invention relates to methods of treating patients with WHIM syndrome or related disorders, such as myelokathexis, in which X4P-001 is administered in order to reduce the activity of CXCR4. The methods demonstrate surprising effectiveness, with comparatively little toxicity.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: January 11, 2022
    Assignee: X4 Pharmaceuticals, Inc.
    Inventors: Robert D. Arbeit, Paula Marie Ragan
  • Methods for treating cancer
    Patent number: 10953003
    Abstract: The present invention relates to methods of treating patients with advanced forms of cancer, such as clear cell renal cell carcinoma, in which X4P-001 is administered in order to reduce angiogenic escape that typically occurs with TKI therapy. The methods demonstrate surprising results, including regression of tumor size and cell number, with comparatively little toxicity.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: March 23, 2021
    Assignees: X4 PHARMACEUTICALS, INC., GENZYME CORP.
    Inventors: Paula Marie Ragan, Robert D. Arbeit, Kieran James Crowley
  • METHODS FOR TREATING IMMUNODEFICIENCY DISEASE
    Publication number: 20200268739
    Abstract: The present invention relates to methods of treating patients with WHIM syndrome or related disorders, such as myelokathexis, in which X4P-001 is administered in order to reduce the activity of CXCR4. The methods demonstrate surprising effectiveness, with comparatively little toxicity.
    Type: Application
    Filed: February 28, 2020
    Publication date: August 27, 2020
    Inventors: Robert D. Arbeit, Paula Marie Ragan
  • Methods for treating immunodeficiency disease
    Patent number: 10610527
    Abstract: The present invention relates to methods of treating patients with WHIM syndrome or related disorders, such as myelokathexis, in which X4P-001 is administered in order to reduce the activity of CXCR4. The methods demonstrate surprising effectiveness, with comparatively little toxicity.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: April 7, 2020
    Assignee: X4 PHARMACEUTICALS, INC.
    Inventors: Robert D. Arbeit, Paula Marie Ragan
  • METHODS FOR TREATING IMMUNODEFICIENCY DISEASE
    Publication number: 20190083485
    Abstract: The present invention relates to methods of treating patients with WHIM syndrome or related disorders, such as myelokathexis, in which X4P-001 is administered in order to reduce the activity of CXCR4. The methods demonstrate surprising effectiveness, with comparatively little toxicity.
    Type: Application
    Filed: December 22, 2016
    Publication date: March 21, 2019
    Inventors: Robert D. Arbeit, Paula Marie Ragan
  • METHODS FOR TREATING CANCER
    Publication number: 20190030023
    Abstract: The present invention relates to methods of treating patients with advanced forms of cancer, such as metastatic melanoma and non-small cell lung cancer, in which X4P-001 is administered as monotherapy or in combination with immune checkpoint inhibitors, such as pembrolizumab. The methods demonstrate surprising results, including regression of disease, with comparatively little toxicity.
    Type: Application
    Filed: January 23, 2017
    Publication date: January 31, 2019
    Inventors: Robert D. Arbeit, Paula Marie Ragan
  • METHODS FOR TREATING CANCER
    Publication number: 20180369229
    Abstract: The present invention relates to methods of treating patients with advanced forms of cancer, such as clear cell renal cell carcinoma, in which X4P-001 is administered in order to reduce angiogenic escape that typically occurs with TKI therapy. The methods demonstrate surprising results, including regression of tumor size and cell number, with comparatively little toxicity.
    Type: Application
    Filed: December 14, 2016
    Publication date: December 27, 2018
    Applicants: X4 Pharmaceuticals, Inc., Genzyme Corp.
    Inventors: Paula Marie Ragan, Robert D. Arbeit, Kieran James Crowley
  • METHODS FOR TREATING CANCER
    Publication number: 20180369167
    Abstract: The present invention relates to methods of treating patients with advanced forms of cancer, such as clear cell renal cell carcinoma, in which X4P-001 is administered in order to reduce angiogenic escape that typically occurs with TKI therapy. The methods demonstrate surprising results, including regression of tumor size and cell number, with comparatively little toxicity.
    Type: Application
    Filed: December 14, 2016
    Publication date: December 27, 2018
    Inventors: Robert D. Arbeit, Paula Marie Ragan, Michael B. Atkins, James W. Mier, David McDermott