Patents by Inventor Paula Sundstrom

Paula Sundstrom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for identifying an agent that inhibits —mediated host cell differentiation
    Patent number: 8617832
    Abstract: The present invention features a method for identifying an agent that inhibits Candida albicans-mediated differentiation of keratinocytes. Agents identified by the screening assay of the invention find application in the prevention and treatment of candidiasis.
    Type: Grant
    Filed: August 13, 2010
    Date of Patent: December 31, 2013
    Assignee: Trustees of Dartmouth College
    Inventor: Paula Sundstrom
  • Method for Identifying an Agent that Inhibits Candida albicans-Mediated Host Cell Differentiation
    Publication number: 20120156697
    Abstract: The present invention features a method for identifying an agent that inhibits Candida albicans-mediated differentiation of keratinocytes. Agents identified by the screening assay of the invention find application in the prevention and treatment of candidiasis.
    Type: Application
    Filed: August 13, 2010
    Publication date: June 21, 2012
    Applicant: Trustees of Dartmouth College
    Inventor: Paula Sundstrom
  • Methods for regulating bud-hypha transitions and cAMP levels in
    Patent number: 7270975
    Abstract: The infection of a mammalian host by a microorganism can be prevented or treated through the alteration of the C. albicans homologue of the high affinity phosphodiesterase, PDE2, gene and/or the adenylate cyclase-associated protein gene. These methods may be used in the identification, prevention or treatment of microbial infection of mammalian hosts such as immunocompromised or immunosuppressed humans, for example, those having AIDS or undergoing transplantation or anti-cancer therapy.
    Type: Grant
    Filed: September 29, 2003
    Date of Patent: September 18, 2007
    Assignee: Trustees of Dartmouth College
    Inventor: Paula Sundstrom
  • Inhibition of transglutaminase-mediated microbial interaction with a mammalian host
    Patent number: 7135182
    Abstract: The infection of a mammalian host by a microorganism can be prevented or treated through the administration of substrates for transglutaminases or antibodies against such substrates that inhibit the transglutaminase-mediated interaction of the microorganism with the mammalian host. These compounds may be used in the identification, prevention or treatment of microbial infection of mammalian hosts such as immunocompromised or immunosuppressed humans, for example, those having AIDS or undergoing transplantation or anti-cancer therapy.
    Type: Grant
    Filed: April 8, 2002
    Date of Patent: November 14, 2006
    Assignee: Trustees of Dartmouth College
    Inventors: Paula Sundstrom, Steven D. Bradway
  • Nucleic acids essential for expression of hyphal-specific genes and methods for using the same
    Publication number: 20050244861
    Abstract: The present invention relates to the identification of nucleic acids required for the regulation of HWP1 expression in Candida albicans and the use of these nucleic acids in identifying agents which inhibit the expression of HWP1. Such agents can be used in the prevention or treatment of Candida infection of mammalian hosts such as immunocompromised or immunosuppressed humans, for example, those having AIDS or undergoing transplantation or anti-cancer therapy.
    Type: Application
    Filed: March 17, 2005
    Publication date: November 3, 2005
    Inventor: Paula Sundstrom
  • Methods for regulating bud-hypha transitions and cAMP levels in Candida albicans
    Publication number: 20040120968
    Abstract: The infection of a mammalian host by a microorganism can be prevented or treated through the alteration of the C. albicans homologue of the high affinity phosphodiesterase, PDE2, gene and/or the adenylate cyclase-associated protein gene. These methods may be used in the identification, prevention or treatment of microbial infection of mammalian hosts such as immunocompromised or immunosuppressed humans, for example, those having AIDS or undergoing transplantation or anti-cancer therapy.
    Type: Application
    Filed: September 29, 2003
    Publication date: June 24, 2004
    Inventor: Paula Sundstrom
  • Methods for regulating bud-hypha transitions and cAMP levels by the adenylate cyclase-associated protein gene, CAP1
    Publication number: 20040121468
    Abstract: The infection of a mammalian host by a microorganism can be prevented or treated through the disruption of the C. albicans homologue of adenylate cyclase-associated protein gene. These methods may be used in the identification, prevention or treatment of microbial infection of mammalian hosts such as immunocompromised or immunosuppressed humans, for example, those having AIDS or undergoing transplantation or anti-cancer therapy.
    Type: Application
    Filed: January 13, 2004
    Publication date: June 24, 2004
    Inventor: Paula Sundstrom
  • Methods for regulating bud-hypha transitions and cAMP levels by the adenylate cyclase-associated protein gene, CAP1
    Patent number: 6706688
    Abstract: The infection of a mammalian host by a microorganism can be prevented or treated through the disruption of the C. albicans homologue of adenylate cyclase-associated protein gene. These methods may be used in the identification, prevention or treatment of microbial infection of mammalian hosts such as immunocompromised or immunosuppressed humans, for example, those having AIDS or undergoing transplantation or anti-cancer therapy.
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: March 16, 2004
    Inventor: Paula Sundstrom
  • Methods for regulating bud-hypha transitions and cAMP levels by the adenylate cyclase-associated protein gene, CAP1
    Publication number: 20030104994
    Abstract: The infection of a mammalian host by a microorganism can be prevented or treated through the disruption of the C. albicans homologue of adenylate cyclase-associated protein gene. These methods may be used in the identification, prevention or treatment of microbial infection of mammalian hosts such as immunocompromised or immunosuppressed humans, for example, those having AIDS or undergoing transplantation or anti-cancer therapy.
    Type: Application
    Filed: March 9, 2001
    Publication date: June 5, 2003
    Inventor: Paula Sundstrom
  • Methods for altering the expression of hyphal-specific genes
    Publication number: 20020142468
    Abstract: The infection of a mammalian host by a microorganism can be prevented or treated through the alteration of the expression of hypha-specific gene. These compounds may be used in the identification, prevention or treatment of microbial infection of mammalian hosts such as immunocompromised or immunosuppressed humans, for example, those having AIDS or undergoing transplantation or anti-cancer therapy.
    Type: Application
    Filed: November 29, 2000
    Publication date: October 3, 2002
    Inventor: Paula Sundstrom
  • Inhibition of transglutaminase-mediated microbial interaction with a mammalian host
    Publication number: 20020122804
    Abstract: The infection of a mammalian host by a microorganism can be prevented or treated through the administration of substrates for transglutaminases or antibodies against such substrates that inhibit the transglutaminase-mediated interaction of the microorganism with the mammalian host. These compounds may be used in the identification, prevention or treatment of microbial infection of mammalian hosts such as immunocompromised or immunosuppressed humans, for example, those having AIDS or undergoing transplantation or anti-cancer therapy.
    Type: Application
    Filed: April 8, 2002
    Publication date: September 5, 2002
    Inventors: Paula Sundstrom, Steven D. Bradway
  • Inhibition of transglutaminase-mediated microbial interaction with a mammalian host
    Patent number: 6388056
    Abstract: The infection of a mammalian host by a microorganism can be prevented or treated through the administration of substrates for transglutaminases or antibodies against such substrates that inhibit the transglutaminase-mediated interaction of the microorganism with the mammalian host. These compounds may be used in the identification, prevention or treatment of microbial infection of mammalian hosts such as immunocompromised or immunosuppressed humans, for example, those having AIDS or undergoing transplantation or anti-cancer therapy.
    Type: Grant
    Filed: October 26, 1998
    Date of Patent: May 14, 2002
    Inventors: Paula Sundstrom, Steven D. Bradway