Patents by Inventor Paulina Budynek

Paulina Budynek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of producing bacteriophage preparations comprising purification using affinity chromatography
    Patent number: 10160956
    Abstract: The proposed method facilitates the single-stage and at the same time effective purification of phage preparations for therapeutic uses, and facilitates the maintenance of bacteriophage antibacterial activity both in the case of displacement of the bacteriophage from the resin and its proteolytic release. The protein modification of the phage capsid with appropriate binding motifs makes it possible to purify therapeutically bacteriophage strains using affinity chromatography. The proposed method is useful in the display of selected polypeptided on a bacteriophage capsid without the need to genetically modify the bacteriophage, and thus makes it possible to produce phage preparations for various uses using wild-type phages occurring naturally or others not additionally modified for phage-display purposes.
    Type: Grant
    Filed: October 28, 2011
    Date of Patent: December 25, 2018
    Inventors: Krystyna Dabrowska, Anna Oslizlo, Paulina Budynek, Agnieszka Otrowicz, Andrzej Gorski, Grzegorz Figura, Barbara Owczarek, Agnieszka Kopciuch
  • METHOD OF PRODUCING BACTERIOPHAGE PREPARATIONS COMPRISING PURIFICATION USING AFFINITY CHROMATOGRAPHY
    Publication number: 20130295647
    Abstract: The proposed method facilitates the single-stage and at the same time effective purification of phage preparations for therapeutic uses, and facilitates the maintenance of bacteriophage antibacterial activity both in the case of displacement of the bacteriophage from the resin and its proteolytic release. The protein modification of the phage capsid with appropriate binding motifs makes it possible to purify therapeutically bacteriophage strains using affinity chromatography. The proposed method is useful in the display of selected polypeptided on a bacteriophage capsid without the need to genetically modify the bacteriophage, and thus makes it possible to produce phage preparations for various uses using wild-type phages occurring naturally or others not additionally modified for phage-display purposes.
    Type: Application
    Filed: October 28, 2011
    Publication date: November 7, 2013
    Applicant: INSTYTUT IMMUNOLOGII I TERAPII DOSWIADCZALNEJ PAN
    Inventors: Krystyna Dabrowska, Anna Oslizlo, Paulina Budynek, Agnieszka Otrowicz, Andrzej Gorski, Grzegorz Figura, Barbara Owczarek, Agnieszka Kopciuch