Patents by Inventor Pauline Malinge

Pauline Malinge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240254223
    Abstract: Described herein are compositions and methods to produce masked antibodies useful in a variety of therapeutic indications.
    Type: Application
    Filed: September 1, 2023
    Publication date: August 1, 2024
    Inventors: Limin SHANG, Giovanni MAGISTRELLI, Nicolas FISCHER, Elise Sylvie Blanche LECHINE, Pauline MALINGE
  • Patent number: 11261262
    Abstract: The invention provides heterodimer bispecific antigen-binding molecules that include a first polypeptide that does not include an IgG CH1 domain and a second polypeptide where there is at least one mutation in the IgG CH3 domain that abolishes the ability of the second polypeptide to bind CH3-specific affinity media such that the first and second polypeptides have different affinities with respect to CH1 and CH3 specific affinity reagents that allows rapid isolation by differential binding. The invention also provides bispecific antibodies that have CH1 and CH3 regions with different affinities with respect to affinity reagents that allows rapid isolation by differential binding. The invention also concerns bispecific antibodies which are heterodimers of two IgG heavy chains that differ by at least two amino acids that allow for rapid isolation based on a differential affinity of one mutated heavy chain and a second mutated heavy chain toward two different affinity reagents.
    Type: Grant
    Filed: September 3, 2014
    Date of Patent: March 1, 2022
    Assignee: NovImmune SA
    Inventors: Nicolas Fischer, Giovanni Magistrelli, Francois Rousseau, Krzysztof Masternak, Pauline Malinge
  • Publication number: 20200231707
    Abstract: The invention relates to antigen-binding proteins or antibodies having heterodimers of heavy chains, i.e., two immunoglobulin heavy chains that differ by at least one or two amino acid(s) that allows for isolation of the antigen-binding protein based on a differential affinity of an immunoglobulin heavy chain and a modified/mutated immunoglobulin heavy chain toward an affinity reagent. The invention also relates antigen-binding proteins, including bispecific antibodies, having IgG CH1 regions with different affinities with respect to affinity reagent(s) that allows rapid isolation by differential binding of the IgG regions to the affinity reagent(s).
    Type: Application
    Filed: November 27, 2019
    Publication date: July 23, 2020
    Applicant: NovImmune SA
    Inventors: Nicolas FISCHER, Giovanni MAGISTRELLI, Francois ROUSSEAU, Krzysztof MASTERNAK, Pauline MALINGE
  • Patent number: 10494446
    Abstract: The invention relates to antigen-binding proteins or antibodies having heterodimers of heavy chains, i.e., two immunoglobulin heavy chains that differ by at least one or two amino acid(s) that allows for isolation of the antigen-binding protein based on a differential affinity of an immunoglobulin heavy chain and a modified/mutated immunoglobulin heavy chain toward an affinity reagent. The invention also relates antigen-binding proteins, including bispecific antibodies, having IgG CH1 regions with different affinities with respect to affinity reagent(s) that allows rapid isolation by differential binding of the IgG regions to the affinity reagent(s).
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: December 3, 2019
    Assignee: NovImmune SA
    Inventors: Nicolas Fischer, Giovanni Magistrelli, Francois Rousseau, Krzysztof Masternak, Pauline Malinge
  • Publication number: 20190226001
    Abstract: Methods are provided to improve the expression of protein complexes by tuning the expression levels of each component required for the assembly of the complex. These methods are effective in limiting the expression of the dominant chain and, thus, equilibrating their relative abundance. The methods provided herein lead to a significant increase in productivity and final bispecific yields both in transient expression systems as well as in stably transfected mammalian cells.
    Type: Application
    Filed: September 28, 2018
    Publication date: July 25, 2019
    Inventors: Giovanni MAGISTRELLI, Pauline MALINGE, Yves POITEVIN, Nicolas FISCHER
  • Patent number: 10113193
    Abstract: Methods are provided to improve the expression of protein complexes by tuning the expression levels of each component required for the assembly of the complex. These methods are effective in limiting the expression of the dominant chain and, thus, equilibrating their relative abundance. The methods provided herein lead to a significant increase in productivity and final bispecific yields both in transient expression systems as well as in stably transfected mammalian cells.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: October 30, 2018
    Assignee: NovImmune SA
    Inventors: Giovanni Magistrelli, Pauline Malinge, Yves Poitevin, Nicolas Fischer
  • Publication number: 20180057611
    Abstract: The invention relates to antigen-binding proteins or antibodies having heterodimers of heavy chains, i.e., two immunoglobulin heavy chains that differ by at least one or two amino acid(s) that allows for isolation of the antigen-binding protein based on a differential affinity of an immunoglobulin heavy chain and a modified/mutated immunoglobulin heavy chain toward an affinity reagent. The invention also relates antigen-binding proteins, including bispecific antibodies, having IgG CH1 regions with different affinities with respect to affinity reagent(s) that allows rapid isolation by differential binding of the IgG regions to the affinity reagent(s).
    Type: Application
    Filed: November 13, 2017
    Publication date: March 1, 2018
    Inventors: Nicolas FISCHER, Giovanni MAGISTRELLI, Francois ROUSSEAU, Krzysztof MASTERNAK, Pauline MALINGE
  • Patent number: 9815909
    Abstract: The invention relates to antigen-binding proteins or antibodies having heterodimers of heavy chains, i.e., two immunoglobulin heavy chains that differ by at least one or two amino acid(s) that allows for isolation of the antigen-binding protein based on a differential affinity of an immunoglobulin heavy chain and a modified/mutated immunoglobulin heavy chain toward an affinity reagent. The invention also relates antigen-binding proteins, including bispecific antibodies, having IgG CH1 regions with different affinities with respect to affinity reagent(s) that allows rapid isolation by differential binding of the IgG regions to the affinity reagent(s).
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: November 14, 2017
    Assignee: NOVIMMUNE S.A.
    Inventors: Nicolas Fischer, Giovanni Magistrelli, Francois Rousseau, Krzysztof Masternak, Pauline Malinge
  • Publication number: 20160289727
    Abstract: Methods are provided to improve the expression of protein complexes by tuning the expression levels of each component required for the assembly of the complex. These methods are effective in limiting the expression of the dominant chain and, thus, equilibrating their relative abundance. The methods provided herein lead to a significant increase in productivity and final bispecific yields both in transient expression systems as well as in stably transfected mammalian cells.
    Type: Application
    Filed: March 31, 2016
    Publication date: October 6, 2016
    Inventors: Giovanni Magistrelli, Pauline Malinge, Yves Poitevin, Nicolas Fischer
  • Publication number: 20150094451
    Abstract: The invention provides heterodimer bispecific antigen-binding molecules that include a first polypeptide that does not include an IgG CH1 domain and a second polypeptide having an immunoglobulin constant region where there is at least one mutation in the IgG CH3 domain that abolishes the ability of the second polypeptide to bind CH3-specific affinity media such that the first and second polypeptides have different affinities with respect to CH1 and CH3 specific affinity reagents that allows rapid isolation by differential binding of the first and second polypeptides to these affinity reagents. The invention also provides bispecific antibodies that have IgG CH1 and CH3 regions with different affinities with respect to affinity reagents that allows rapid isolation by differential binding of the IgG regions to these affinity reagents. The invention also concerns bispecific antibodies which are heterodimers of heavy chains, i.e.
    Type: Application
    Filed: September 3, 2014
    Publication date: April 2, 2015
    Inventors: Nicolas Fischer, Giovanni Magistrelli, Francois Rousseau, Krzysztof Masternak, Pauline Malinge
  • Publication number: 20140051833
    Abstract: The invention relates to antigen-binding proteins or antibodies having heterodimers of heavy chains, i.e., two immunoglobulin heavy chains that differ by at least one or two amino acid(s) that allows for isolation of the antigen-binding protein based on a differential affinity of an immunoglobulin heavy chain and a modified/mutated immunoglobulin heavy chain toward an affinity reagent. The invention also relates antigen-binding proteins, including bispecific antibodies, having IgG CH1 regions with different affinities with respect to affinity reagent(s) that allows rapid isolation by differential binding of the IgG regions to the affinity reagent(s).
    Type: Application
    Filed: March 13, 2013
    Publication date: February 20, 2014
    Inventors: Nicolas Fischer, Giovanni Magistrelli, Francois Rousseau, Krzysztof Mastemak, Pauline Malinge