Patents by Inventor Paulo A. Garcia
Paulo A. Garcia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12059197Abstract: The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. Included is a method of treating tissue with electrical energy, the method comprising: delivering electrical energy to tissue using one or more electroporation devices comprising one or more electrodes; and cooling the tissue, surrounding tissue, one or more of the electrodes, or one or more of the electroporation devices to minimize heating. In embodiments, the invention can be used to treat solid tumors, such as brain tumors, and in some embodiments, exemplary methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.Type: GrantFiled: February 10, 2021Date of Patent: August 13, 2024Assignee: Virginia Tech Intellectual Properties, Inc.Inventors: Rafael V. Davalos, Paulo A. Garcia, John L. Robertson, John H. Rossmeisl, Robert E. Neal, II
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Patent number: 11974800Abstract: The present invention relates to the field of medical treatment of diseases and disorders, as well as the field of biomedical engineering. Embodiments of the invention relate to the delivery of Irreversible Electroporation (IRE) through the vasculature of organs to treat tumors embedded deep within the tissue or organ, or to decellularize organs to produce a scaffold from existing animal tissue with the existing vasculature intact. In particular, methods of administering non-thermal irreversible electroporation (IRE) in vivo are provided for the treatment of tumors located in vascularized tissues and organs. Embodiments of the invention further provide scaffolds and tissues from natural sources created using IRE ex vivo to remove cellular debris, maximize recellularization potential, and minimize foreign body immune response. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.Type: GrantFiled: January 20, 2020Date of Patent: May 7, 2024Assignee: Virginia Tech Intellectual Properties, Inc.Inventors: Michael B. Sano, Rafael V. Davalos, John L Robertson, Paulo A. Garcia, Robert E. Neal
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Patent number: 11952568Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.Type: GrantFiled: April 5, 2019Date of Patent: April 9, 2024Assignee: Virginia Tech Intellectual Properties, Inc.Inventors: Robert E. Neal, II, Paulo A. Garcia, Rafael V. Davalos, John H. Rossmeisl, John L. Robertson
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Publication number: 20240074804Abstract: The present invention relates to medical devices and methods for treating a lesion such as a vascular stenosis using non-thermal irreversible electroporation (NTIRE). Embodiments of the present invention provide a balloon catheter type NTIRE device for treating a target lesion comprising a plurality of electrodes positioned along the balloon that are electrically independent from each other so as to be individually selectable in order to more precisely treat an asymmetrical lesion in which the lesion extends only partially around the vessel.Type: ApplicationFiled: November 6, 2023Publication date: March 7, 2024Inventors: Robert E. Neal, Paulo A. Garcia, Rafael V. Davalos, Peter Callas
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Publication number: 20240008911Abstract: Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (IRE) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body.Type: ApplicationFiled: July 7, 2023Publication date: January 11, 2024Inventors: Rafael V. Davalos, John H. Rossmeisl, Paulo A. Garcia
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Patent number: 11737810Abstract: Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (IRE) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body.Type: GrantFiled: October 13, 2020Date of Patent: August 29, 2023Assignee: Virginia Tech Intellectual Properties, Inc.Inventors: Rafael V. Davalos, John H. Rossmeisl, Paulo A. Garcia
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Publication number: 20230212551Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.Type: ApplicationFiled: March 10, 2023Publication date: July 6, 2023Inventors: Robert E. Neal, II, Paulo A. Garcia, Rafael V. Davalos, John H. Rossmeisl, John L. Robertson
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Publication number: 20230157759Abstract: The invention provides for a system for estimating a 3-dimensional treatment volume for a device that applies treatment energy through a plurality of electrodes defining a treatment area, the system comprising a memory, a display device, a processor coupled to the memory and the display device, and a treatment planning module stored in the memory and executable by the processor. In one embodiment, the treatment planning module is adapted to generate an estimated first 3-dimensional treatment volume for display in the display device based on the ratio of a maximum conductivity of the treatment area to a baseline conductivity of the treatment area. The invention also provides for a method for estimating 3-dimensional treatment volume, the steps of which are executable through the processor. In embodiments, the system and method are based on a numerical model which may be implemented in computer readable code which is executable through a processor.Type: ApplicationFiled: January 24, 2023Publication date: May 25, 2023Inventors: Paulo A. Garcia, Rafael V. Davalos
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Patent number: 11655466Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.Type: GrantFiled: July 24, 2015Date of Patent: May 23, 2023Assignee: Virginia Tech Intellectual Properties, Inc.Inventors: Robert E. Neal, II, Paulo A. Garcia, Rafael V. Davalos, John H. Rossmeisl, John L. Robertson
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Patent number: 11607271Abstract: The invention provides for a system for estimating a 3-dimensional treatment volume for a device that applies treatment energy through a plurality of electrodes defining a treatment area, the system comprising a memory, a display device, a processor coupled to the memory and the display device, and a treatment planning module stored in the memory and executable by the processor. In one embodiment, the treatment planning module is adapted to generate an estimated first 3-dimensional treatment volume for display in the display device based on the ratio of a maximum conductivity of the treatment area to a baseline conductivity of the treatment area. The invention also provides for a method for estimating 3-dimensional treatment volume, the steps of which are executable through the processor. In embodiments, the system and method are based on a numerical model which may be implemented in computer readable code which is executable through a processor.Type: GrantFiled: October 17, 2019Date of Patent: March 21, 2023Assignee: Virginia Tech Intellectual Properties, Inc.Inventors: Paulo A. Garcia, Rafael V. Davalos
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Patent number: 11453873Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.Type: GrantFiled: August 8, 2019Date of Patent: September 27, 2022Assignee: Virginia Tech Intellectual Properties, Inc.Inventors: Rafael V. Davalos, Paulo A. Garcia, John H. Rossmeisl, John L. Robertson, Robert E. Neal, II
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Publication number: 20220151688Abstract: Systems and methods are provided for modeling and for providing a graphical representation of tissue heating and electric field distributions for medical treatment devices that apply electrical treatment energy through one or a plurality of electrodes. In embodiments, methods comprise: providing one or more parameters of a treatment protocol for delivering one or more electrical pulses to tissue through a plurality of electrodes; modeling electric and heat distribution in the tissue based on the parameters; and displaying a graphical representation of the modeled electric and heat distribution. In another embodiment, a treatment planning module is adapted to generate an estimated target ablation zone based on a combination of one or more parameters for an irreversible electroporation protocol and one or more tissue-specific conductivity parameters.Type: ApplicationFiled: February 3, 2022Publication date: May 19, 2022Inventors: Paulo A. Garcia, Christopher B. Arena, Michael B. Sano, Rafael V. Davalos
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Patent number: 11272979Abstract: Systems and methods are provided for modeling and for providing a graphical representation of tissue heating and electric field distributions for medical treatment devices that apply electrical treatment energy through one or a plurality of electrodes. In embodiments, methods comprise: providing one or more parameters of a treatment protocol for delivering one or more electrical pulses to tissue through a plurality of electrodes; modeling electric and heat distribution in the tissue based on the parameters; and displaying a graphical representation of the modeled electric and heat distribution. In another embodiment, a treatment planning module is adapted to generate an estimated target ablation zone based on a combination of one or more parameters for an irreversible electroporation protocol and one or more tissue-specific conductivity parameters.Type: GrantFiled: October 5, 2018Date of Patent: March 15, 2022Assignee: Virginia Tech Intellectual Properties, Inc.Inventors: Paulo A. Garcia, Christopher B. Arena, Michael B. Sano, Rafael V. Davalos
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Patent number: 11254926Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.Type: GrantFiled: May 6, 2019Date of Patent: February 22, 2022Assignee: Virginia Tech Intellectual Properties, Inc.Inventors: Robert E. Neal, II, Paulo A. Garcia, Rafael V. Davalos, John H. Rossmeisl, John L. Robertson
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Publication number: 20220022945Abstract: Systems and methods are provided for modeling and for providing a graphical representation of tissue heating and electric field distributions for medical treatment devices that apply electrical treatment energy through one or a plurality of electrodes. In embodiments, methods comprise: providing one or more parameters of a treatment protocol for delivering one or more electrical pulses to tissue through a plurality of electrodes; modeling electric and heat distribution in the tissue based on the parameters; and displaying a graphical representation of the modeled electric and heat distribution. In another embodiment, a treatment planning module is adapted to generate an estimated target ablation zone based on a combination of one or more parameters for an irreversible electroporation protocol and one or more tissue-specific conductivity parameters.Type: ApplicationFiled: October 5, 2018Publication date: January 27, 2022Inventors: Paulo A. Garcia, Christopher B. Arena, Michael B. Sano, Rafael V. Davalos
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Publication number: 20210186600Abstract: The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. Included is a method of treating tissue with electrical energy, the method comprising: delivering electrical energy to tissue using one or more electroporation devices comprising one or more electrodes; and cooling the tissue, surrounding tissue, one or more of the electrodes, or one or more of the electroporation devices to minimize heating. In embodiments, the invention can be used to treat solid tumors, such as brain tumors, and in some embodiments, exemplary methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.Type: ApplicationFiled: February 10, 2021Publication date: June 24, 2021Inventors: Rafael V. Davalos, Paulo A. Garcia, John L. Robertson, John H. Rossmeisl, Robert E. Neal, II
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Patent number: 10959772Abstract: The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. Included is a method of treating tissue with electrical energy, the method comprising: delivering electrical energy to tissue using one or more electroporation devices comprising one or more electrodes; and cooling the tissue, surrounding tissue, one or more of the electrodes, or one or more of the electroporation devices to minimize heating. In embodiments, the invention can be used to treat solid tumors, such as brain tumors, and in some embodiments, exemplary methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.Type: GrantFiled: February 14, 2019Date of Patent: March 30, 2021Assignee: Virginia Tech Intellectual Properties, Inc.Inventors: Rafael V. Davalos, Paulo A. Garcia, John L. Robertson, John H. Rossmeisl, Robert E. Neal, II
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Publication number: 20210022795Abstract: Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (IRE) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body.Type: ApplicationFiled: October 13, 2020Publication date: January 28, 2021Inventors: Rafael V. Davalos, John H. Rossmeisl, Paulo A. Garcia
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Patent number: 10828085Abstract: Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (IRE) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body.Type: GrantFiled: November 1, 2018Date of Patent: November 10, 2020Inventors: Rafael V. Davalos, John H. Rossmeisl, Paulo A. Garcia
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Patent number: 10828086Abstract: Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (IRE) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body.Type: GrantFiled: December 26, 2018Date of Patent: November 10, 2020Inventors: Rafael V. Davalos, John H. Rossmeisl, Paulo A. Garcia