Patents by Inventor Paulo Jia Ching Lin

Paulo Jia Ching Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PEGYLATED LIPIDS
    Publication number: 20250161227
    Abstract: Compounds are provided having the following Formula (I): or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein R1, R2, R3, m, and n are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
    Type: Application
    Filed: November 15, 2024
    Publication date: May 22, 2025
    Inventors: Steven M. Ansell, Paulo Jia Ching Lin, Ying K. Tam
  • mRNA THERAPY WITH REDUCED IMMUNE REACTOGENICITY
    Publication number: 20240424133
    Abstract: The present disclosure provides compositions and methods for mRNA therapy with reduced immune reactogenicity.
    Type: Application
    Filed: January 24, 2024
    Publication date: December 26, 2024
    Inventors: Isabel M. CHU, Yang XIANG, Stefano GULLA, Jason J. ZHANG, Paulo Jia Ching LIN, Ying K. TAM
  • LIPID NANOPARTICLE FORMULATIONS
    Publication number: 20230372537
    Abstract: Improved formulations of lipid nanoparticles are provided. Use of the lipid nanoparticles for delivery of a therapeutic agent and methods for their preparation are also provided.
    Type: Application
    Filed: June 9, 2023
    Publication date: November 23, 2023
    Inventors: Michael J. Hope, Barbara Mui, Paulo Jia Ching Lin, Christopher J. Barbosa, Thomas D. Madden, Steven M. Ansell, Xinyao Du
  • Lipid nanoparticle formulations
    Patent number: 11712481
    Abstract: Improved formulations of lipid nanoparticles are provided. Use of the lipid nanoparticles for delivery of a therapeutic agent and methods for their preparation are also provided.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: August 1, 2023
    Assignee: Acuitas Therapeutics, Inc.
    Inventors: Michael J. Hope, Barbara Mui, Paulo Jia Ching Lin, Christopher J. Barbosa, Thomas D. Madden, Steven M. Ansell, Xinyao Du
  • IMPROVED LIPID NANOPARTICLES FOR DELIVERY OF NUCLEIC ACIDS
    Publication number: 20230097090
    Abstract: Lipid nanoparticles having improved properties are provided. Use of the lipid nanoparticles for delivery of a therapeutic agent to primates for treatment of various indications is also described.
    Type: Application
    Filed: August 14, 2020
    Publication date: March 30, 2023
    Inventors: Ying K. TAM, Paulo Jia Ching LIN, Sean SEMPLE, Christopher J. BARBOSA
  • LIPID NANOPARTICLE MRNA VACCINES
    Publication number: 20210251898
    Abstract: The invention relates to mRNA comprising lipid nanoparticles and their medical uses. The lipid nanoparticles of the present invention comprise a cationic lipid according to formula (I), (II) or (III) and/or a PEG lipid according to formula (IV), as well as an mRNA compound comprising an mRNA sequence encoding an antigenic peptide or protein. The invention further relates to the use of said lipid nanoparticles as vaccines or medicaments, in particular with respect to influenza or rabies vaccination.
    Type: Application
    Filed: January 6, 2021
    Publication date: August 19, 2021
    Applicants: CureVac AG, Acuitas Therapeutics Inc.
    Inventors: Patrick BAUMHOF, Mariola FOTIN-MLECZEK, Regina HEIDENREICH, Michael J. HOPE, Edith JASNY, Sandra LAZZARO, Paulo Jia Ching LIN, Johannes LUTZ, Barbara MUI, Benjamin PETSCH, Susanne RAUCH, Kim Ellen SCHMIDT, Ying TAM
  • LIPID NANOPARTICLE MRNA VACCINES
    Publication number: 20200163878
    Abstract: The invention relates to mRNA comprising lipid nanoparticles and their medical uses. The lipid nanoparticles of the present invention comprise a cationic lipid according to formula (I), (II) or (III) and/or a PEG lipid according to formula (IV), as well as an mRNA compound comprising an mRNA sequence encoding an antigenic peptide or protein. The invention further relates to the use of said lipid nanoparticles as vaccines or medicaments, in particular with respect to influenza or rabies vaccination.
    Type: Application
    Filed: October 26, 2017
    Publication date: May 28, 2020
    Inventors: Patrick BAUMHOF, Mariola FOTIN-MLECZEK, Regina HEIDENREICH, Michael J. HOPE, Edith JASNY, Sandra LAZZARO, Paulo Jia Ching LIN, Johannes LUTZ, Barbara MUI, Benjamin PETSCH, Susanne RAUCH, Kim Ellen SCHWENDT, Ying TAM
  • DELIVERY OF TARGET SPECIFIC NUCLEASES
    Publication number: 20180185516
    Abstract: Described herein are lipid nanoparticles comprising cationic lipids and other lipids and also comprising engineered nucleases facilitate transfer of nucleic acids to cells.
    Type: Application
    Filed: December 8, 2017
    Publication date: July 5, 2018
    Inventors: Steven M. Ansell, Christopher Barbosa, Anthony Conway, Xinyao Du, Michael J. Hope, Michael C. Holmes, Gary K. Lee, Paulo Jia Ching Lin, Thomas Madden, Barbara Mui