Patents by Inventor Paulo Maciag

Paulo Maciag has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions comprising angiogenic factors and methods of use thereof
    Patent number: 10695410
    Abstract: The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.
    Type: Grant
    Filed: May 28, 2018
    Date of Patent: June 30, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Matthew Seavey, Yvonne Paterson, Paulo Maciag, Duane Sewell
  • COMPOSITIONS COMPRISING ANGIOGENIC FACTORS AND METHODS OF USE THEREOF
    Publication number: 20190117750
    Abstract: The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.
    Type: Application
    Filed: May 28, 2018
    Publication date: April 25, 2019
    Inventors: Matthew SEAVEY, Yvonne PATERSON, Paulo MACIAG, Duane SEWELL
  • Non-hemolytic LLO fusion proteins and methods of utilizing same
    Patent number: 10189885
    Abstract: The present invention provides recombinant proteins or peptides comprising a mutated listeriolysin O (LLO) protein or fragment thereof, comprising a substitution or internal deletion of the cholesterol-binding domain or a portion thereof, fusion proteins or peptides comprising same, nucleotide molecules encoding same, and vaccine vectors comprising or encoding same. The present invention also provides methods of utilizing recombinant proteins, peptides, nucleotide molecules, and vaccine vectors of the present invention to induce an immune response to a peptide of interest.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: January 29, 2019
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Yvonne Paterson, Paulo Maciag
  • Compositions comprising angiogenic factors and methods of use thereof
    Patent number: 9981024
    Abstract: The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: May 29, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Matthew Seavey, Yvonne Paterson, Paulo Maciag, Duane Sewell
  • Compositions comprising angiogenic factors and methods of use thereof
    Patent number: 9919038
    Abstract: The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: March 20, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Matthew Seavey, Yvonne Paterson, Paulo Maciag, Duane Sewell
  • Dual delivery system for heterologous antigens
    Patent number: 9650639
    Abstract: Provided herein are recombinant Listeria strains expressing a tumor-specific antigenic polypeptide and, optionally, an angiogenic polypeptide wherein a nucleic acid molecule encoding at least one of the polypeptides is operably integrated into the Listeria genome in an open reading frame with a nucleic acid sequence encoding a PEST-containing polypeptide, methods of preparing same, and methods of inducing an immune response, and treating, inhibiting, or suppressing cancer or tumors comprising administering same.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: May 16, 2017
    Assignee: ADVAXIS, INC.
    Inventors: Paulo Maciag, Anu Wallecha, Vafa Shahabi
  • Dual delivery system for heterologous antigens
    Patent number: 9644212
    Abstract: Provided herein are recombinant Listeria strains expressing a tumor-specific antigenic polypeptide and, optionally, an angiogenic polypeptide wherein a nucleic acid molecule encoding at least one of the polypeptides is operably integrated into the Listeria genome in an open reading frame with a nucleic acid sequence encoding a PEST-containing polypeptide, methods of preparing same, and methods of inducing an immune response, and treating, inhibiting, or suppressing cancer or tumors comprising administering same.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: May 9, 2017
    Assignee: ADVAXIS, INC.
    Inventors: Paulo Maciag, Anu Wallecha, Vafa Shahabi
  • COMPOSITIONS COMPRISING ANGIOGENIC FACTORS AND METHODS OF USE THEREOF
    Publication number: 20170049867
    Abstract: The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.
    Type: Application
    Filed: August 1, 2016
    Publication date: February 23, 2017
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Matthew SEAVEY, Yvonne Paterson, Paulo Maciag, Duane Sewell
  • Non-hemolytic LLO fusion proteins and methods of utilizing same
    Patent number: 9499602
    Abstract: The present invention provides recombinant proteins or peptides comprising a mutated listeriolysin O (LLO) protein or fragment thereof, comprising a substitution or internal deletion of the cholesterol-binding domain or a portion thereof, fusion proteins or peptides comprising same, nucleotide molecules encoding same, and vaccine vectors comprising or encoding same. The present invention also provides methods of utilizing recombinant proteins, peptides, nucleotide molecules, and vaccine vectors of the present invention to induce an immune response to a peptide of interest.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: November 22, 2016
    Assignees: ADVAXIS, INC., THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Yvonne Paterson, Paulo MaCiag
  • Compositions comprising angiogenic factors and methods of use thereof
    Patent number: 9408898
    Abstract: The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: August 9, 2016
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Matthew Seavey, Yvonne Paterson, Paulo Maciag, Duane Sewell
  • COMPOSITIONS COMPRISING ANGIOGENIC FACTORS AND METHODS OF USE THEREOF
    Publication number: 20160206716
    Abstract: The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.
    Type: Application
    Filed: January 15, 2016
    Publication date: July 21, 2016
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Matthew Seavey, Yvonne Paterson, Paulo Maciag, Duane Sewell
  • NON-HEMOLYTIC LLO FUSION PROTEINS AND METHODS OF UTILIZING SAME
    Publication number: 20160024173
    Abstract: The present invention provides recombinant proteins or peptides comprising a mutated listeriolysin O (LLO) protein or fragment thereof, comprising a substitution or internal deletion of the cholesterol-binding domain or a portion thereof, fusion proteins or peptides comprising same, nucleotide molecules encoding same, and vaccine vectors comprising or encoding same. The present invention also provides methods of utilizing recombinant proteins, peptides, nucleotide molecules, and vaccine vectors of the present invention to induce an immune response to a peptide of interest.
    Type: Application
    Filed: July 1, 2015
    Publication date: January 28, 2016
    Inventors: Yvonne PATERSON, Paulo Maciag
  • COMPOSITIONS COMPRISING ANGIOGENIC FACTORS AND METHODS OF USE THEREOF
    Publication number: 20150079034
    Abstract: The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.
    Type: Application
    Filed: June 13, 2014
    Publication date: March 19, 2015
    Inventors: Matthew SEAVEY, Yvonne Paterson, Paulo Maciag, Duane Sewell
  • DUAL DELIVERY SYSTEM FOR HETEROLOGOUS ANTIGENS
    Publication number: 20140335120
    Abstract: Provided herein are recombinant Listeria strains expressing a tumor-specific antigenic polypeptide and, optionally, an angiogenic polypeptide wherein a nucleic acid molecule encoding at least one of the polypeptides is operably integrated into the Listeria genome in an open reading frame with a nucleic acid sequence encoding a PEST-containing polypeptide, methods of preparing same, and methods of inducing an immune response, and treating, inhibiting, or suppressing cancer or tumors comprising administering same.
    Type: Application
    Filed: July 25, 2014
    Publication date: November 13, 2014
    Inventors: Paulo MACIAG, Anu Wallecha, Vafa Shahabi
  • DUAL DELIVERY SYSTEM FOR HETEROLOGOUS ANTIGENS
    Publication number: 20140314708
    Abstract: Provided herein are recombinant Listeria strains expressing a tumor-specific antigenic polypeptide and, optionally, an angiogenic polypeptide wherein a nucleic acid molecule encoding at least one of the polypeptides is operably integrated into the Listeria genome in an open reading frame with a nucleic acid sequence encoding a PEST-containing polypeptide, methods of preparing same, and methods of inducing an immune response, and treating, inhibiting, or suppressing cancer or tumors comprising administering same.
    Type: Application
    Filed: March 11, 2014
    Publication date: October 23, 2014
    Applicant: Advaxis, Inc.
    Inventors: Paulo Maciag, Anu Wallecha, Vafa Shahabi
  • NON-HEMOLYTIC LLO FUSION PROTEINS AND METHODS OF UTILIZING SAME
    Publication number: 20140248304
    Abstract: The present invention provides recombinant proteins or peptides comprising a mutated listeriolysin O (LLO) protein or fragment thereof, comprising a substitution or internal deletion of the cholesterol-binding domain or a portion thereof, fusion proteins or peptides comprising same, nucleotide molecules encoding same, and vaccine vectors comprising or encoding same. The present invention also provides methods of utilizing recombinant proteins, peptides, nucleotide molecules, and vaccine vectors of the present invention to induce an immune response to a peptide of interest.
    Type: Application
    Filed: February 12, 2014
    Publication date: September 4, 2014
    Applicants: Advaxis, The Trustees of the University of Pennsylvania
    Inventors: Yvonne PATERSON, Paulo Maciag
  • Compositions comprising angiogenic factors and methods of use thereof
    Patent number: 8778329
    Abstract: The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.
    Type: Grant
    Filed: March 4, 2010
    Date of Patent: July 15, 2014
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Matthew Seavey, Yvonne Paterson, Paulo Maciag, Duane Sewell
  • Compositions comprising HMW-MAA and fragments thereof, and methods of use thereof
    Patent number: 8268326
    Abstract: This invention provides recombinant polypeptides comprising a fragment of a High Molecular Weight Melanoma-Associated Antigen (HMW-MAA), recombinant Listeria strains comprising same, and methods of inducing an anti-HMW-MAA and anti HER-2/neu immune response thus treating and impeding the growth of tumors, comprising administering same.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: September 18, 2012
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Yvonne Paterson, Paulo Maciag, Matthew Seavey, Soldano Ferrone
  • Compositions comprising HMW-MAA and fragments thereof, and methods of use thereof
    Patent number: 8241636
    Abstract: This invention provides recombinant polypeptides comprising a fragment of a High Molecular Weight Melanoma-Associated Antigen (HMW-MAA), recombinant Listeria strains comprising same, and methods of inducing an immune response and treating and impeding the growth of tumors, comprising administering same.
    Type: Grant
    Filed: August 15, 2007
    Date of Patent: August 14, 2012
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Yvonne Paterson, Paulo Maciag, Soldano Ferrone
  • COMPOSITIONS COMPRISING ANGIOGENIC FACTORS AND METHODS OF USE THEREOF
    Publication number: 20120114685
    Abstract: The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.
    Type: Application
    Filed: March 4, 2010
    Publication date: May 10, 2012
    Inventors: Matthew Seavey, Yvonne Paterson, Paulo Maciag, Duane Sewell, Catherine Sewell