Abstract: Disclosed are compositions and methods for mediating immunosuppressive myelopoiesis. Additionally, disclosed herein are combination therapies for treating cancers and methods of using the same.

Abstract: Disclosed are compositions and methods for engineered Notch ligands for activating Notch signaling, enhancing eh efficacy of adoptive T cell immunotherapy, making a T cell resistant to tumor suppression, and/or treating a cancer. In one aspect, disclosed herein are methods of activating Notch signaling comprising contacting T cells (such as, for example CD8+ T cells, CD4+ T cells, chimeric antigen receptor 15 (CAR) T cells, tumor infiltrating lymphocytes (TILs), and/or marrow infiltrating lymphocytes (MILS)) with a chemically designed Notch ligand.

Abstract: Technologies for migrating content items from a storage network to an online content management system are provided. In some examples, a method can include receiving a request to migrate a share on a server at a source environment to a content management system that is separate from the source environment, the share having a structure representing a hierarchy of each content item within the share; identifying accounts at the source environment having access permissions configured at the source environment for the share on the server; mapping the accounts at the source environment to corresponding accounts at the content management system; creating a copy of the share at the content management system, the copy of the share being created in association with the corresponding accounts on the content management system; and migrating, to the content management system, the access permissions configured at the source environment for the share on the server.

Abstract: Technologies for migrating content items from a storage network to an online content management system are provided. In some examples, a method can include receiving a request to migrate a share on a server at a source environment to a content management system that is separate from the source environment, the share having a structure representing a hierarchy of each content item within the share; identifying accounts at the source environment having access permissions configured at the source environment for the share on the server; mapping the accounts at the source environment to corresponding accounts at the content management system; creating a copy of the share at the content management system, the copy of the share being created in association with the corresponding accounts on the content management system; and migrating, to the content management system, the access permissions configured at the source environment for the share on the server.