Patents by Inventor Paulraj Kirubakaran Lawrence
Paulraj Kirubakaran Lawrence has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10603371Abstract: The present invention provides attenuated P. multocida strains that elicit an immune response in animal P. multocida, compositions comprising said strains, methods of vaccination against P. multocida, and kits for use with such methods and compositions. The invention further provides novel, genetically-engineered mutations in P. multocida hyaD and nanPU genes, which are useful in the production of novel attenuated P. multocida bacterial strains.Type: GrantFiled: August 4, 2017Date of Patent: March 31, 2020Assignee: BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC.Inventors: Paulraj Kirubakaran Lawrence, Russell F. Bey, Randy R. Simonson
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Patent number: 10058601Abstract: The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said strains, methods of vaccination against M. haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.Type: GrantFiled: May 12, 2017Date of Patent: August 28, 2018Assignee: MERIAL INC.Inventors: Russell F. Bey, Paulraj Kirubakaran Lawrence, Randy R. Simonson
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Publication number: 20180015157Abstract: The present invention provides attenuated P. multocida strains that elicit an immune response in animal P. multocida, compositions comprising said strains, methods of vaccination against P. multocida, and kits for use with such methods and compositions. The invention further provides novel, genetically-engineered mutations in P. multocida hyaD and nanPU genes, which are useful in the production of novel attenuated P. multocida bacterial strains.Type: ApplicationFiled: August 4, 2017Publication date: January 18, 2018Applicant: MERIAL INC.Inventors: Paulraj Kirubakaran Lawrence, Russell F. Bey, Randy R. Simonson
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Patent number: 9757445Abstract: The present invention provides attenuated P. multocida strains that elicit an immune response in animal P. multocida, compositions comprising said strains, methods of vaccination against P. multocida, and kits for use with such methods and compositions. The invention further provides novel, genetically-engineered mutations in P. multocida hyaD and nanPU genes, which are useful in the production of novel attenuated P. multocida bacterial strains.Type: GrantFiled: October 30, 2014Date of Patent: September 12, 2017Assignee: MERIAL INC.Inventors: Paulraj Kirubakaran Lawrence, Russell F. Bey
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Publication number: 20170246286Abstract: The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said strains, methods of vaccination against M. haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.Type: ApplicationFiled: May 12, 2017Publication date: August 31, 2017Applicant: MERIAL INC.Inventors: Russell F. Bey, Paulraj Kirubakaran Lawrence, Randy R. Simonson
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Patent number: 9675682Abstract: The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said strains, methods of vaccination against M. haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.Type: GrantFiled: January 8, 2016Date of Patent: June 13, 2017Assignee: MERIAL, INC.Inventors: Russell F. Bey, Paulraj Kirubakaran Lawrence, Randy R. Simonson
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Patent number: 9504740Abstract: The present invention is a Haemophilus parasuis vaccine against serovar type 4 capable of triggering a protective immune response when administered to pigs as a killed vaccine. The present invention is also a method for vaccinating swine against Haemophilus parasuis infection, serovar type 4, by a) clonally propagating one or more cells which are capable of triggering an immune response against Haemophilus parasuis infection, serovar type 4, that protects the pig against Haemophilus parasuis infection, and b) combining an immunologically effective amount of the cells with a veterinarily acceptable carrier in a form suitable for administration as a vaccine to the pig, and c) administering as a killed vaccine. The cell culture is from a pathogenic parent strain.Type: GrantFiled: October 6, 2014Date of Patent: November 29, 2016Assignee: MERIAL, INC.Inventors: Paulraj Kirubakaran Lawrence, Russell F. Bey
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Publication number: 20160199477Abstract: The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said strains, methods of vaccination against M. haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.Type: ApplicationFiled: January 8, 2016Publication date: July 14, 2016Applicant: Merial Inc.Inventors: Russell F. Bey, Paulraj Kirubakaran Lawrence, Randy R. Simonson
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Patent number: 9370561Abstract: The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said strains, methods of vaccination against M. haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.Type: GrantFiled: November 8, 2013Date of Patent: June 21, 2016Assignee: MERIAL, INC.Inventors: Russell F. Bey, Paulraj Kirubakaran Lawrence, Randy R. Simonson
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Publication number: 20160158336Abstract: The present invention provides attenuated M. haemolytica strains that elicit an immune response in animals against M. haemolytica, compositions comprising said strains, methods of vaccination against M. haemolytica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.Type: ApplicationFiled: November 6, 2015Publication date: June 9, 2016Inventors: Russell F Bey, Paulraj Kirubakaran Lawrence, Randy R Simonson, Robert E Briggs, Fred M Tatum
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Patent number: 9289484Abstract: The present invention provides attenuated S. suis strains that elicit an immune response in animals against S. suis, compositions comprising said strains, methods of vaccination against S. suis, and kits for use with such methods and compositions. The invention further provides novel, mutagenically-induced mutations in S. suis genes, which are useful in the production of novel attenuated S. suis bacterial strains.Type: GrantFiled: June 24, 2013Date of Patent: March 22, 2016Assignee: MERIAL, INC.Inventors: Russell F Bey, Paulraj Kirubakaran Lawrence, Randy R Simonson, Kamesh Reddy Sirigireddy, Danielle A McKeown
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Publication number: 20150125487Abstract: The present invention provides attenuated P. multocida strains that elicit an immune response in animal P. multocida, compositions comprising said strains, methods of vaccination against P. multocida, and kits for use with such methods and compositions. The invention further provides novel, genetically-engineered mutations in P. multocida hyaD and nanPU genes, which are useful in the production of novel attenuated P. multocida bacterial strains.Type: ApplicationFiled: October 30, 2014Publication date: May 7, 2015Applicant: MERIAL LIMITEDInventors: Paulraj Kirubakaran Lawrence, Russell F. Bey
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Publication number: 20150098968Abstract: The present invention is a Haemophilus parasuis vaccine against serovar type 4 capable of triggering a protective immune response when administered to pigs as a killed vaccine. The present invention is also a method for vaccinating swine against Haemophilus parasuis infection, serovar type 4, by a) clonally propagating one or more cells which are capable of triggering an immune response against Haemophilus parasuis infection, serovar type 4, that protects the pig against Haemophilus parasuis infection, and b) combining an immunologically effective amount of the cells with a veterinarily acceptable carrier in a form suitable for administration as a vaccine to the pig, and c) administering as a killed vaccine. The cell culture is from a pathogenic parent strain.Type: ApplicationFiled: October 6, 2014Publication date: April 9, 2015Applicant: MERIAL LIMITEDInventors: Paulraj Kirubakaran Lawrence, Russell F. Bey
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Publication number: 20140170190Abstract: The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said strains, methods of vaccination against M. haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.Type: ApplicationFiled: November 8, 2013Publication date: June 19, 2014Applicant: MERIAL LIMITEDInventors: Russell F Bey, Paulraj Kirubakaran Lawrence, Randy R Simonson
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Publication number: 20140004144Abstract: The present invention provides attenuated S. suis strains that elicit an immune response in animal S. suis, compositions comprising said strains, methods of vaccination against S. suis, and kits for use with such methods and compositions. The invention further provides novel, mutagenically-induced mutations in S. suis genes, which are useful in the production of novel attenuated S. suis bacterial strains.Type: ApplicationFiled: June 24, 2013Publication date: January 2, 2014Applicant: MERIAL LIMITEDInventors: Russell F Bey, Paulraj Kirubakaran Lawrence, Randy R Simonson, Kamesh Reddy Sirigireddy, Danielle A McKeown