Patents by Inventor Paulus Bernardus Wilhelmus Ten Kortenaar

Paulus Bernardus Wilhelmus Ten Kortenaar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for rapid solution synthesis of peptides
    Patent number: 7435791
    Abstract: The present invention relates to a process for rapid solution synthesis of a peptide, the process comprising repetitive cycles of steps (a)-(d): (a) a coupling step, using an excess of an activated carboxylic component to acylate an amino component, (b) a quenching step in which a scavenger is used to remove residual activated carboxylic functions, wherein the scavenger may also be used for deprotection of the growing peptide, (c) one or more aqueous extractions and optionally, (d) a separate deprotection step, followed by one or more aqueous extractions, characterised in that the process comprises at least one step (b), referred to as step (b?), in which an amine or a thiol comprising a free anion or a latent anion is used as a scavenger of residual activated carboxylic functions. During the process of this invention the growing peptide need not be isolated until the final peptide sequence has been obtained.
    Type: Grant
    Filed: October 23, 2003
    Date of Patent: October 14, 2008
    Assignee: N.V. Organon
    Inventors: Ivo Franci Eggen, Paulus Bernardus Wilhelmus Ten Kortenaar, Cornelis Albert Gruson Haasnoot
  • Process for the preparation of peptides
    Publication number: 20050101764
    Abstract: The present invention relates to a process for the preparation of peptides using an excess of an activated carboxylic component to acylate an amino component, wherein after the acylation an amine comprising a free anion or a latent anion is used as a scavenger of residual activated carboxylic functions. This process is useful for the preparation of oligo- and polypeptides and, more generally, in the preparation of compounds containing one or more amide bonds.
    Type: Application
    Filed: December 14, 2004
    Publication date: May 12, 2005
    Inventors: Ivo Eggen, Paulus Bernardus Wilhelmus Ten Kortenaar
  • Process for the preparation of peptides
    Patent number: 6864357
    Abstract: The present invention relates to a process for the preparation of peptides using an excess of an activated carboxylic component to acylate an amino component, wherein after the acylation an amine comprising a free anion or a latent anion is used as a scavenger of residual activated carboxylic functions. This process is useful for the preparation of oligo- and polypeptides and, more generally, in the preparation of compounds containing one or more amide bonds.
    Type: Grant
    Filed: July 19, 2002
    Date of Patent: March 8, 2005
    Assignee: Akzo Nobel N.V.
    Inventors: Ivo Franci Eggen, Paulus Bernardus Wilhelmus Ten Kortenaar
  • Process for rapid solution synthesis of peptides
    Publication number: 20040087768
    Abstract: The present invention relates to a process for rapid solution synthesis of a peptide, the process comprising repetitive cycles of steps (a)-(d):
    Type: Application
    Filed: October 23, 2003
    Publication date: May 6, 2004
    Inventors: Ivo Franci Eggen, Paulus Bernardus Wilhelmus Ten Kortenaar, Cornelis Albert Gruson Haasnoot
  • Process for rapid solution synthesis of peptides
    Publication number: 20040082760
    Abstract: The present invention relates to a process for rapid solution synthesis of a peptide, the process comprising repetitive cycles of steps (a)-(d):
    Type: Application
    Filed: October 22, 2003
    Publication date: April 29, 2004
    Inventors: Ivo Franci Eggen, Paulus Bernardus Wilhelmus Ten Kortenaar, Cornelis Albert Gruson Haasnoot
  • Process for rapid solution synthesis of peptides
    Publication number: 20030018164
    Abstract: The present invention relates to a process for rapid solution synthesis of a peptide, the process comprising repetitive cycles of steps (a)-(d):
    Type: Application
    Filed: July 19, 2002
    Publication date: January 23, 2003
    Inventors: Ivo Franci Eggen, Paulus Bernardus Wilhelmus Ten Kortenaar, Cornelis Albert Gruson Haasnoot
  • Process for the preparation of peptides
    Publication number: 20030018163
    Abstract: The present invention relates to a process for the preparation of peptides using an excess of an activated carboxylic component to acylate an amino component, wherein after the acylation an amine comprising a free anion or a latent anion is used as a scavenger of residual activated carboxylic functions.
    Type: Application
    Filed: July 19, 2002
    Publication date: January 23, 2003
    Inventors: Ivo Franci Eggen, Paulus Bernardus Wilhelmus Ten Kortenaar