Patents by Inventor Paulus J. A. Krimpenfort

Paulus J. A. Krimpenfort has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transgenic mice depleted in a mature lymphocytic cell-type
    Patent number: 5591669
    Abstract: Transgenic mice having a phenotype characterized by the substantial depletion of a mature lymphocytic cell type otherwise naturally occurring in the species from which the transgenic mouse is derived. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell of the lymphocytic cell type which is depleted. The transgene comprised is a DNA sequence encoding a lymphatic polypeptide variant which inhibits maturation of the lymphocytic cell type.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: January 7, 1997
    Assignee: GenPharm International, Inc.
    Inventors: Paulus J. A. Krimpenfort, Antonius J. M. Berns
  • Transgenic mice depleted in mature T-cells and methods for making transgenic mice
    Patent number: 5434340
    Abstract: Transgenic mice having a phenotype characterized by the substantial absence of mature T lymphocytes otherwise naturally occurring in said mice. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell of the T lymphocyte which is depleted. The transgene comprises a DNA sequence encoding a T cell receptor polypeptide variant which inhibits maturation of the T lymphocyte.
    Type: Grant
    Filed: July 27, 1992
    Date of Patent: July 18, 1995
    Assignee: GenPharm International, Inc.
    Inventors: Paulus J. A. Krimpenfort, Antonius J. M. Berns
  • Transgenic mice depleted in mature T-cells and methods for making transgenic mice
    Patent number: 5175384
    Abstract: Transgenic mice having a phenotype characterized by the substantial absence of mature T lymphocytes otherwise naturally occurring in said mice. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell of the T lymphocyte which is depleted. The transgene comprises a DNA sequence encoding a T cell receptor polypeptide variant which inhibits maturation of the T lymphocyte.
    Type: Grant
    Filed: December 5, 1988
    Date of Patent: December 29, 1992
    Assignee: GenPharm International
    Inventors: Paulus J. A. Krimpenfort, Antonius J. M. Berns