Abstract: The present embodiments are directed to methods of using glycine transporter inhibitors, such as GlyT1 inhibitors, or pharmaceutically acceptable salts, solvates or prodrugs thereof, or pharmaceutical compositions thereof, for preventing or treating polycythemia, and related syndromes thereof.

Abstract: The present embodiments are directed to methods of using glycine transporter inhibitors, such as GlyT1 inhibitors, or pharmaceutically acceptable salts, solvates or prodrugs thereof, or pharmaceutical compositions thereof, for preventing or treating polycythemia, and related syndromes thereof.

Abstract: The present embodiments are directed to methods of using glycine transporter inhibitors, such as GlyT1 inhibitors, or pharmaceutically acceptable salts, solvates or prodrugs thereof, or pharmaceutical compositions thereof, for preventing or treating anemia associated with a ribosomal disorder, and related syndromes thereof.

Abstract: The present embodiments are directed to methods of using glycine transporter inhibitors, such as GlyT1 inhibitors, or pharmaceutically acceptable salts, solvates or prodrugs thereof, or pharmaceutical compositions thereof, for preventing or treating polycythemia, and related syndromes thereof.

Abstract: Provided herein are compositions and methods for preventing, attenuating or treating T cell mediated intestinal disorders. In particular, provided herein are methods for preventing, attenuating or treating T cell mediated intestinal disorders characterized with reduced intestinal epithelial cell (IEC) specific mitochondrial complex II component intrinsic succinate dehydrogenase A (SDHA) activity and/or expression through use of compositions comprising a therapeutic agent capable of preventing and/or hindering reduction of IEC related SDHA activity and/or expression.

Abstract: The present disclosure relates to methods of treating or preventing graft-versus-host disease (GVHD) comprising administering to the subject a pharmaceutically effective amount of a compound disclosed herein. The present disclosure also relates to pharmaceutical compositions and pharmaceutical kits suitable for the treatment or prevention.

Abstract: This disclosure provides miRNA/mRNA pairs that can be used to increase the efficacy of T cells or to down-modulate T cell efficacy and restore equilibrium.

Abstract: This disclosure provides miRNA/mRNA pairs that can be used to increase the efficacy of T cells or to down-modulate T cell efficacy and restore equilibrium.

Abstract: Provided herein are compositions and methods for administering bacterial strains to reduce GvHD and improve survival after allogeneic BMT.

Abstract: In one embodiment, a composite Network of Networks is created out of a set otherwise separate constituent networks by a system that includes an operations station and one or more gateways. The operations station is configured to transmit a set of policies for processing data packets travelling through a composite network, where the composite network includes two or more independent constituent networks. The gateways are each communicatively connected between two or more attached constituent networks. A first gateway is configured to receive a data packet from a first constituent network attached to the first gateway; determine one or more real-time network situational awareness characteristics; process the data packet by applying the policies to the data packet based at least in part on the network situational awareness characteristics; and transmit the data packet to a second network attached to the first gateway and distinct from the first constituent network.

Abstract: Provided herein are compositions and methods for administering bacterial strains to reduce GvHD and improve survival after allogeneic BMT.

Abstract: This disclosure provides miRNA/mRNA pairs that can be used to increase the efficacy of T cells or to down-modulate T cell efficacy and restore equilibrium.

Abstract: In one embodiment, a composite Network of Networks is created out of a set otherwise separate constituent networks by a system that includes an operations station and one or more gateways. The operations station is configured to transmit a set of policies for processing data packets travelling through a composite network, where the composite network includes two or more independent constituent networks. The gateways are each communicatively connected between two or more attached constituent networks. A first gateway is configured to receive a data packet from a first constituent network attached to the first gateway; determine one or more real-time network situational awareness characteristics; process the data packet by applying the policies to the data packet based at least in part on the network situational awareness characteristics; and transmit the data packet to a second network attached to the first gateway and distinct from the first constituent network.

Abstract: In one embodiment, a composite Network of Networks is created out of a set otherwise separate constituent networks by a system that includes an operations station and one or more gateways. The operations station is configured to transmit a set of policies for processing data packets travelling through a composite network, where the composite network includes two or more independent constituent networks. The gateways are each communicatively connected between two or more attached constituent networks. A first gateway is configured to receive a data packet from a first constituent network attached to the first gateway; determine one or more real-time network situational awareness characteristics; process the data packet by applying the policies to the data packet based at least in part on the network situational awareness characteristics; and transmit the data packet to a second network attached to the first gateway and distinct from the first constituent network.

Abstract: A Personal Emergency Response System (PERS) includes a call device (10) with a call button (12), LAN (20), WAN (22), and locator service(s) (26, 42). The PERS further includes a hub or gateway device (30). The call device is programmed to periodically send transmissions to the hub or gateway device using the LAN, recognize based on the transmissions that the call device is no longer in a home geo-fence, and transition to communicating using the WAN in response to recognizing that the call device is no longer in the home geo-fence. The transition also includes turning on the locator service(s). The call button triggers the call device to contact the hub or gateway device using the LAN, or a PERS call center when using the WAN. A speaker (14) and microphone (16) are built into the call device for use when communicating using the WAN.

Abstract: A mobile button device (10) comprises a call button (12), a local wireless link (20) to a communicator (30), and a cellular connection (22). The mobile button device is programmed to perform an alarm reporting method including: originating an alarm by sending the alarm via the local wireless link to the communicator for alarm reporting by the communicator; after sending the alarm to the communicator, monitoring alarm reporting status via the local wireless link to the communicator; and reporting the alarm via the cellular connection in response to the monitoring determining that the communicator failed to report the alarm. For example, the monitoring may include polling the communicator via the local wireless link and the monitoring determines that the communicator failed to report the alarm if the polling indicates the communicator is unavailable (70) or a timeout condition (72) is reached.

Abstract: A mobile button device (10) comprises a call button (12), a local wireless link (20) to a communicator (30), and a cellular connection (22). The mobile button device is programmed to perform an alarm reporting method including: originating an alarm by sending the alarm via the local wireless link to the communicator for alarm reporting by the communicator; after sending the alarm to the communicator, monitoring alarm reporting status via the local wireless link to the communicator; and reporting the alarm via the cellular connection in response to the monitoring determining that the communicator failed to report the alarm. For example, the monitoring may include polling the communicator via the local wireless link and the monitoring determines that the communicator failed to report the alarm if the polling indicates the communicator is unavailable (70) or a timeout condition (72) is reached.

Abstract: A Personal Emergency Response System (PERS) includes a call device (10) with a call button (12), LAN (20), WAN (22), and locator service(s) (26, 42). The PERS further includes a hub or gateway device (30). The call device is programmed to periodically send transmissions to the hub or gateway device using the LAN, recognize based on the transmissions that the call device is no longer in a home geo-fence, and transition to communicating using the WAN in response to recognizing that the call device is no longer in the home geo-fence. The transition also includes turning on the locator service(s). The call button triggers the call device to contact the hub or gateway device using the LAN, or a PERS call center when using the WAN. A speaker (14) and microphone (16) are built into the call device for use when communicating using the WAN.

Abstract: In one embodiment, a composite Network of Networks is created out of a set otherwise separate constituent networks by a system that includes an operations station and one or more gateways. The operations station is configured to transmit a set of policies for processing data packets travelling through a composite network, where the composite network includes two or more independent constituent networks. The gateways are each communicatively connected between two or more attached constituent networks. A first gateway is configured to receive a data packet from a first constituent network attached to the first gateway; determine one or more real-time network situational awareness characteristics; process the data packet by applying the policies to the data packet based at least in part on the network situational awareness characteristics; and transmit the data packet to a second network attached to the first gateway and distinct from the first constituent network.

Abstract: Data flows in a network are managed by dynamically determining bandwidth usage and available bandwidth for IP-ABR service data flows and dynamically allocating a portion of the available bandwidth to the IP-ABR data flows. Respective bandwidth requests from network hosts are received and an optimal window size for a sender host is determined based upon bandwidth allocated for the data flow and a round trip time of a segment to provide self-pacing of the data flow.