Patents by Inventor Pavankumar N.V. Petluru

Pavankumar N.V. Petluru has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Germanium-containing camptothecin analogues
    Publication number: 20140073793
    Abstract: The present invention discloses: (i) the novel germanium-containing camptothecin compound, 7[2?-trimethylgermanyl]ethyl-20(S) camptothecin, and pharmaceutically-acceptable salts thereof; (ii) methods of synthesis of said novel germanium-containing camptothecin compound, 7[2?-trimethylgermanyl]ethyl-20(S) camptothecin, and pharmaceutically-acceptable salts; (iii) pharmaceutically-acceptable formulations comprising said novel germanium-containing camptothecin compound, 7[2?-trimethylgermanyl]ethyl-20(S) camptothecin, and pharmaceutically-acceptable salts thereof; and (iv) methods of administration of said novel germanium-containing camptothecin compound, 7[2?-trimethylgermanyl]ethyl-20(S) camptothecin, and pharmaceutically-acceptable salts thereof to subjects in need thereof, including subjects with cancer.
    Type: Application
    Filed: September 7, 2012
    Publication date: March 13, 2014
    Inventors: Xinghai Chen, Harry Kochat, Pavankumar N.V. Petluru, Aulma Parker, Frederick H. Hausheer
  • Platinum analogs with bis-nitrile-containing ligands
    Patent number: 7777060
    Abstract: Disclosed herein are novel platinum-based analogs possessing two nitrile substituent groups (bis-nitrile) covalently-bonded to the platinum. Also disclosed herein are the reaction schemes for the synthesis of said platinum complexes, as well as quantitative in vitro IC50 data.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: August 17, 2010
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventors: Xinghai Chen, Pavankumar N. V. Petluru, Qiuli Huang, Kesavaram Narkunan, Frederick Hausheer
  • Platinum analogs with bis-nitrile-containing ligands
    Publication number: 20080194680
    Abstract: Disclosed herein are novel platinum-based analogs possessing two nitrile substituent groups (bis-nitrile) covalently-bonded to the platinum. Also disclosed herein are the reaction schemes for the synthesis of said platinum complexes, as well as quantitative in vitro IC50 data.
    Type: Application
    Filed: October 30, 2007
    Publication date: August 14, 2008
    Inventors: Xinghai Chen, Pavankumar N.V. Petluru, Qiuli Huang, Kesavaram Narkunan, Frederick Hausheer
  • Highly lipophilic camptothecin derivatives
    Patent number: 6169080
    Abstract: This invention relates to novel derivatives of camptothecin, and will, particularly to derivatives having a substitution at the C-7 position, or at one of the C-9, C-10, C-11 or C-12 positions, or to disubstituted derivatives having a first substitution at C-7 and a second at one of C-9, C-10, C-11 or C-12. The invention also includes methods of using the compounds as Topoisomerase I inhibitors to treat patients with cancer. The invention also includes pharmaceutical formulations which consist of the novel compounds in solution or suspension with one or more pharmaceutical excipients or dilutes.
    Type: Grant
    Filed: February 11, 1998
    Date of Patent: January 2, 2001
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventors: Frederick H. Hausheer, Kochat Haridas, P. Seetharamulu, Dasharatha G. Reddy, Shijie Yao, Pavankumar N.V. Petluru, Dhanabalan Murali
  • Highly lipophilic camptothecin derivatives
    Patent number: 6028078
    Abstract: Novel compounds, formulations and methods of treating patients with cancer are provided for in this invention. The compounds are derivatives of camptothecin, and specifically relate to compounds having novel substitutions at the C-7 position of the camptothecin scaffold B-ring. The formula I compounds are highly lipophilic, lactone stable, do not require metabolic activation, and are potent antineoplastic compounds.
    Type: Grant
    Filed: October 26, 1998
    Date of Patent: February 22, 2000
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventors: Frederick H. Hausheer, Pavankumar N. V. Petluru, Dasharatha Reddy, Dhanabalan Murali, Kochat Haridas, Peddaiahgari Seetharamulu, Shijie Yao
  • Highly lipophilic camptothecin derivatives
    Patent number: 5910491
    Abstract: Novel compounds, formulations and methods of treating patients with cancer are provided for in this invention. The compounds are derivatives of camptothecin, and specifically relate to compounds having novel substitutions at the C-7 position of the camptothecin scaffold B-ring. The formula I compounds are highly lipophilic, lactone stable, do not require metabolic activation, and are potent antineoplastic compounds.
    Type: Grant
    Filed: August 19, 1997
    Date of Patent: June 8, 1999
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventors: Frederick H. Hausheer, Pavankumar N.V. Petluru, Dasharatha Reddy, Dhanabalan Murali, Kochat Haridas, Peddaiahgari Seetharamulu, Shijie Yao